Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
PCVX	VAXCYTE INC	325,000	$18.89M	2.5%	$52.77	0.0%	COM	92243G108
CRVS	CORVUS PHARMACEUTICALS INC	1,100,000	$16.09M	2.1%	$16.29	0.0%	COM	221015100
DFTX	DEFINIUM THERAPEUTICS INC	598,500	$11.31M	1.5%	$16.29	0.0%	COM SHS	24477V105
IRD	OPUS GENETICS INC	2,250,000	$10.24M	1.3%	$2.74	0.0%	COM	67577R102
CORT	CORCEPT THERAPEUTICS INC	250,000	$10.08M	1.3%	$38.80	0.0%	COM	218352102
—	CRESCENT BIOPHARMA INC.	453,686	$8.334M	1.1%	$18.37	—	COM	38000Q201
SLNO	SOLENO THERAPEUTICS INC	200,000	$6.696M	0.9%	$41.63	0.0%	COM	834203309
ALLO	ALLOGENE THERAPEUTICS INC	2,725,000	$6.649M	0.9%	$1.74	0.0%	COM	019770106
RLMD	RELMADA THERAPEUTICS INC	842,106	$5.861M	0.8%	$4.01	0.0%	COM	75955J402
OCUL	OCULAR THERAPEUTIX INC	350,000	$2.965M	0.4%	$9.83	0.0%	COM	67576A100
ANTX	AN2 THERAPEUTICS INC	749,035	$2.562M	0.3%	$1.13	0.0%	COM	037326105
ORIC	ORIC PHARMACEUTICALS INC	176,500	$2.236M	0.3%	$10.77	0.0%	COM	68622P109
RGNX	REGENXBIO INC	15,000	$126K	0.0%	$11.60	0.0%	COM	75901B107

Increased Positions (13)

KOD KODIAK SCIENCES INC 6.8%

Value $51.88M (+63.3%) Shares 1,361,000 (+19.8%) Est. Cost $13.17 Unrealized +93.0%

RVMD REVOLUTION MEDICINES INC 6.4%

Value $48.63M (+52.6%) Shares 500,000 (+25.0%) Est. Cost $60.98 Unrealized +68.9%

VIR VIR BIOTECHNOLOGY INC 2.2%

Value $16.72M (+343.6%) Shares 1,866,000 (+198.6%) Est. Cost $6.79 Unrealized +6.2%

SRZN SURROZEN INC 2.9%

Value $22.32M (+137.4%) Shares 766,318 (+84.1%) Est. Cost $18.94 Unrealized +17.3%

CAPR CAPRICOR THERAPEUTICS INC 2.4%

Value $17.94M (+91.2%) Shares 590,000 (+81.5%) Est. Cost $18.37 Unrealized +35.5%

PGEN PRECIGEN INC 1.8%

Value $13.54M (+135.7%) Shares 3,500,000 (+154.5%) Est. Cost $4.00 Unrealized +12.5%

ABVX ABIVAX SA 2.9%

Value $22.27M (+32.1%) Shares 200,000 (+60.0%) Est. Cost $96.07 Unrealized —

ZURA ZURA BIO LTD 0.7%

Value $5.355M (+1943.9%) Shares 900,000 (+1700.0%) Est. Cost $5.78 Unrealized +1.9%

QURE UNIQURE NV 1.4%

Value $10.82M (+56.0%) Shares 662,000 (+128.3%) Est. Cost $17.37 Unrealized +35.6%

REPL REPLIMUNE GROUP INC 1.2%

Value $8.989M (+23.3%) Shares 1,175,000 (+56.7%) Est. Cost $10.17 Unrealized -23.2%

CLNN CLENE INC 0.3%

Value $2.354M (+100.8%) Shares 477,515 (+139.1%) Est. Cost $6.31 Unrealized -22.7%

AVTX AVALO THERAPEUTICS INC 0.6%

Value $4.479M (-10.3%) Shares 300,000 (+9.1%) Est. Cost $13.31 Unrealized +16.4%

KPTI KARYOPHARM THERAPEUTICS INC 0.2%

Value $1.685M (-9.3%) Shares 302,536 (+19.8%) Est. Cost $6.36 Unrealized +19.7%

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
KOD	KODIAK SCIENCES INC	1,361,000 (+19.8%)	$51.88M (+63.3%)	6.8%	$13.17	+93.0%	COM	50015M109
RVMD	REVOLUTION MEDICINES INC	500,000 (+25.0%)	$48.63M (+52.6%)	6.4%	$60.98	+68.9%	COM	76155X100
VIR	VIR BIOTECHNOLOGY INC	1,866,000 (+198.6%)	$16.72M (+343.6%)	2.2%	$6.79	+6.2%	COM	92764N102
SRZN	SURROZEN INC	766,318 (+84.1%)	$22.32M (+137.4%)	2.9%	$18.94	+17.3%	COM NEW	86889P208
CAPR	CAPRICOR THERAPEUTICS INC	590,000 (+81.5%)	$17.94M (+91.2%)	2.4%	$18.37	+35.5%	COM NEW	14070B309
PGEN	PRECIGEN INC	3,500,000 (+154.5%)	$13.54M (+135.7%)	1.8%	$4.00	+12.5%	COM	74017N105
ABVX	ABIVAX SA	200,000 (+60.0%)	$22.27M (+32.1%)	2.9%	$96.07	—	SPONSORED ADS	00370M103
ZURA	ZURA BIO LTD	900,000 (+1700.0%)	$5.355M (+1943.9%)	0.7%	$5.78	+1.9%	CLASS A ORD SHS	G9TY5A101
QURE	UNIQURE NV	662,000 (+128.3%)	$10.82M (+56.0%)	1.4%	$17.37	+35.6%	SHS	N90064101
REPL	REPLIMUNE GROUP INC	1,175,000 (+56.7%)	$8.989M (+23.3%)	1.2%	$10.17	-23.2%	COM	76029N106
CLNN	CLENE INC	477,515 (+139.1%)	$2.354M (+100.8%)	0.3%	$6.31	-22.7%	COM NEW	185634201
AVTX	AVALO THERAPEUTICS INC	300,000 (+9.1%)	$4.479M (-10.3%)	0.6%	$13.31	+16.4%	COM NEW	05338F306
KPTI	KARYOPHARM THERAPEUTICS INC	302,536 (+19.8%)	$1.685M (-9.3%)	0.2%	$6.36	+19.7%	COM NEW	48576U205

Exited Positions (4)

— CIDARA THERAPEUTICS INC 1.5%

Value $11.71M Shares 53,000 Est. Cost $64.95 Unrealized —

— MIND MEDICINE MINDMED INC 1.1%

Value $8.014M Shares 598,500 Est. Cost $12.95 Unrealized —

CBIO CRESCENT BIOPHARMA INC. 0.7%

Value $5.381M Shares 453,686 Est. Cost $21.15 Unrealized -47.7%

— NUVATION BIO INC 0.0%

Value $88,000 Shares 266,666 Est. Cost $0.23 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
—	CIDARA THERAPEUTICS INC	53,000	$11.71M	1.5%	$64.95	—	—	171757206
—	MIND MEDICINE MINDMED INC	598,500	$8.014M	1.1%	$12.95	—	—	60255C885
CBIO	CRESCENT BIOPHARMA INC.	453,686	$5.381M	0.7%	$21.15	-47.7%	—	G2545C104
—	NUVATION BIO INC	266,666	$88,000	0.0%	$0.23	—	—	67080N119

Decreased Positions (3)

HELP CYBIN INC 0.4%

Value $3.072M (-47.5%) Shares 640,000 (-10.5%) Est. Cost $6.44 Unrealized +10.4%

PEPG PEPGEN INC 0.1%

Value $483K (-80.2%) Shares 272,892 (-27.0%) Est. Cost $2.80 Unrealized +108.4%

INO INOVIO PHARMACEUTICALS INC 0.5%

Value $4.124M (-2.1%) Shares 2,370,122 (-2.1%) Est. Cost $1.93 Unrealized -15.4%

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
HELP	CYBIN INC	640,000 (-10.5%)	$3.072M (-47.5%)	0.4%	$6.44	+10.4%	COM NEW	23256X407
PEPG	PEPGEN INC	272,892 (-27.0%)	$483K (-80.2%)	0.1%	$2.80	+108.4%	COM	713317105
INO	INOVIO PHARMACEUTICALS INC	2,370,122 (-2.1%)	$4.124M (-2.1%)	0.5%	$1.93	-15.4%	COM SHS	45773H409

Unchanged Positions (25)

TNGX TANGO THERAPEUTICS INC 29.9%

Value $228M Shares 10,876,219 Est. Cost $5.05 Unrealized +135.9%

TERN TERNS PHARMACEUTICALS INC 2.6%

Value $19.77M Shares 375,000 Est. Cost $23.11 Unrealized +62.1%

CELC CELCUITY INC 3.4%

Value $25.68M Shares 225,000 Est. Cost $65.33 Unrealized +64.5%

PTGX PROTAGONIST THERAPEUTICS INC 2.4%

Value $17.92M Shares 170,000 Est. Cost $62.54 Unrealized +33.2%

PALI PALISADE BIO INC 1.1%

Value $8.4M Shares 4,799,875 Est. Cost $1.92 Unrealized -7.2%

UPB UPSTREAM BIO INC 0.2%

Value $1.35M Shares 150,000 Est. Cost $24.89 Unrealized -4.9%

URGN UROGEN PHARMA LTD 1.2%

Value $8.99M Shares 500,000 Est. Cost $9.60 Unrealized +117.2%

KYMR KYMERA THERAPEUTICS INC 3.6%

Value $27.41M Shares 329,100 Est. Cost $43.27 Unrealized +79.3%

IVVD INVIVYD INC 0.3%

Value $1.95M Shares 1,500,000 Est. Cost $2.08 Unrealized -4.9%

GPCR STRUCTURE THERAPEUTICS INC 0.5%

Value $3.615M Shares 75,000 Est. Cost $69.55 Unrealized —

PTCT PTC THERAPEUTICS INC 1.8%

Value $13.63M Shares 200,000 Est. Cost $52.09 Unrealized +41.5%

MLTX MOONLAKE IMMUNOTHERAPEUTICS 0.7%

Value $5.126M Shares 275,000 Est. Cost $48.45 Unrealized -66.9%

AMLX AMYLYX PHARMACEUTICALS INC 1.5%

Value $11.12M Shares 800,000 Est. Cost $4.71 Unrealized +197.3%

PRAX PRAXIS PRECISION MEDICINES I 2.0%

Value $14.97M Shares 46,457 Est. Cost $186.22 Unrealized +67.4%

CTNM CONTINEUM THERAPEUTICS INC 0.8%

Value $6.452M Shares 494,000 Est. Cost $11.41 Unrealized +17.0%

COGT COGENT BIOSCIENCES INC 1.1%

Value $8.66M Shares 225,000 Est. Cost $28.11 Unrealized +32.9%

APGE APOGEE THERAPEUTICS INC 0.8%

Value $5.892M Shares 70,000 Est. Cost $45.27 Unrealized +59.6%

MIST MILESTONE PHARMACEUTICALS IN 0.1%

Value $793K Shares 666,666 Est. Cost $1.76 Unrealized +7.7%

SLDB SOLID BIOSCIENCES INC 0.3%

Value $2.16M Shares 300,000 Est. Cost $5.85 Unrealized +3.4%

NRIX NURIX THERAPEUTICS INC 0.2%

Value $1.55M Shares 100,000 Est. Cost $22.92 Unrealized -24.4%

CYTK CYTOKINETICS INC 0.9%

Value $6.591M Shares 100,000 Est. Cost $41.20 Unrealized +56.4%

LBRX LB PHARMACEUTICALS INC 0.2%

Value $1.726M Shares 70,000 Est. Cost $15.87 Unrealized +41.1%

KALV KALVISTA PHARMACEUTICALS INC 0.1%

Value $411K Shares 20,400 Est. Cost $12.23 Unrealized +26.7%

SRPT SAREPTA THERAPEUTICS INC 0.4%

Value $3.264M Shares 150,000 Est. Cost $20.31 Unrealized -0.4%

SRZNW SURROZEN INC 0.0%

Value $1,067 Shares 66,666 Est. Cost $0.02 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
TNGX	TANGO THERAPEUTICS INC	10,876,219	$228M	29.9%	$5.05	+135.9%	COM	87583X109
TERN	TERNS PHARMACEUTICALS INC	375,000	$19.77M	2.6%	$23.11	+62.1%	COM	880881107
CELC	CELCUITY INC	225,000	$25.68M	3.4%	$65.33	+64.5%	COM	15102K100
PTGX	PROTAGONIST THERAPEUTICS INC	170,000	$17.92M	2.4%	$62.54	+33.2%	COM	74366E102
PALI	PALISADE BIO INC	4,799,875	$8.4M	1.1%	$1.92	-7.2%	COM	696389402
UPB	UPSTREAM BIO INC	150,000	$1.35M	0.2%	$24.89	-4.9%	COM	91678A107
URGN	UROGEN PHARMA LTD	500,000	$8.99M	1.2%	$9.60	+117.2%	COM	M96088105
KYMR	KYMERA THERAPEUTICS INC	329,100	$27.41M	3.6%	$43.27	+79.3%	COM	501575104
IVVD	INVIVYD INC	1,500,000	$1.95M	0.3%	$2.08	-4.9%	COM	00534A102
GPCR	STRUCTURE THERAPEUTICS INC	75,000	$3.615M	0.5%	$69.55	—	SPONSORED ADS	86366E106
PTCT	PTC THERAPEUTICS INC	200,000	$13.63M	1.8%	$52.09	+41.5%	COM	69366J200
MLTX	MOONLAKE IMMUNOTHERAPEUTICS	275,000	$5.126M	0.7%	$48.45	-66.9%	CLASS A ORD	61559X104
AMLX	AMYLYX PHARMACEUTICALS INC	800,000	$11.12M	1.5%	$4.71	+197.3%	COM	03237H101
PRAX	PRAXIS PRECISION MEDICINES I	46,457	$14.97M	2.0%	$186.22	+67.4%	COM NEW	74006W207
CTNM	CONTINEUM THERAPEUTICS INC	494,000	$6.452M	0.8%	$11.41	+17.0%	CL A	21217B100
COGT	COGENT BIOSCIENCES INC	225,000	$8.66M	1.1%	$28.11	+32.9%	COM	19240Q201
APGE	APOGEE THERAPEUTICS INC	70,000	$5.892M	0.8%	$45.27	+59.6%	COM	03770N101
MIST	MILESTONE PHARMACEUTICALS IN	666,666	$793K	0.1%	$1.76	+7.7%	COM	59935V107
SLDB	SOLID BIOSCIENCES INC	300,000	$2.16M	0.3%	$5.85	+3.4%	COM NEW	83422E204
NRIX	NURIX THERAPEUTICS INC	100,000	$1.55M	0.2%	$22.92	-24.4%	COM	67080M103
CYTK	CYTOKINETICS INC	100,000	$6.591M	0.9%	$41.20	+56.4%	COM NEW	23282W605
LBRX	LB PHARMACEUTICALS INC	70,000	$1.726M	0.2%	$15.87	+41.1%	COM SHS	50180M108
KALV	KALVISTA PHARMACEUTICALS INC	20,400	$411K	0.1%	$12.23	+26.7%	COM	483497103
SRPT	SAREPTA THERAPEUTICS INC	150,000	$3.264M	0.4%	$20.31	-0.4%	COM	803607100
SRZNW	SURROZEN INC	66,666	$1,067	0.0%	$0.02	—	*W EXP 08/01/203	86889P117