Ghost Tree Capital, LLC Hedge Fund

CIK: 0001595851 · Show all filings

Period: Q4 2020 (← Previous) (Next →)

Filing Date: Feb 18, 2021

Total Value: $449M (100.0% shares, 0.0% debt)

Holdings (43)

QQQ INVESCO QQQ TR 7.0%

Value $31.37M Shares 100,000 Est. Cost — Unrealized —

SNDX SYNDAX PHARMACEUTICALS INC 6.7%

Value $30.02M Shares 1,350,000 Est. Cost $18.21 Unrealized +13.9%

— TRILLIUM THERAPEUTICS INC 6.4%

Value $28.68M Shares 1,950,000 Est. Cost $7.71 Unrealized —

RCKT ROCKET PHARMACEUTICALS INC 6.1%

Value $27.42M Shares 500,000 Est. Cost $19.92 Unrealized +83.0%

IOVA IOVANCE BIOTHERAPEUTICS INC 5.2%

Value $23.2M Shares 500,000 Est. Cost $24.73 Unrealized +60.5%

APLS APELLIS PHARMACEUTICALS INC 4.1%

Value $18.59M Shares 325,000 Est. Cost $42.30 Unrealized 0.0%

— CONSTELLATION PHARMCETICLS I 4.0%

Value $18M Shares 625,000 Est. Cost $42.72 Unrealized —

ASND ASCENDIS PHARMA A/S 3.9%

Value $17.51M Shares 105,000 Est. Cost $130.34 Unrealized —

ARVN ARVINAS INC 3.9%

Value $17.41M Shares 205,000 Est. Cost $28.07 Unrealized +22.8%

— MERSANA THERAPEUTICS INC 3.6%

Value $15.97M Shares 600,000 Est. Cost $10.98 Unrealized —

FATE FATE THERAPEUTICS INC 3.3%

Value $15M Shares 165,000 Est. Cost $25.07 Unrealized +147.7%

IMVT IMMUNOVANT INC 3.1%

Value $13.86M Shares 300,000 Est. Cost $11.17 Unrealized +314.0%

FOLD AMICUS THERAPEUTICS INC 3.1%

Value $13.85M Shares 600,000 Est. Cost $14.57 Unrealized +40.3%

TGTX TG THERAPEUTICS INC 2.9%

Value $13.01M Shares 250,000 Est. Cost $18.29 Unrealized +84.7%

TVTX TRAVERE THERAPEUTICS INC 2.9%

Value $12.95M Shares 475,000 Est. Cost $23.35 Unrealized 0.0%

COGT COGENT BIOSCIENCES INC 2.8%

Value $12.35M Shares 1,100,000 Est. Cost $10.99 Unrealized 0.0%

— MIRATI THERAPEUTICS INC 2.4%

Value $10.98M Shares 50,000 Est. Cost $82.63 Unrealized —

— MIRATI THERAPEUTICS INC 2.4%

Value $10.98M Shares 50,000 Est. Cost $82.63 Unrealized —

XENE XENON PHARMACEUTICALS INC 2.4%

Value $10.77M Shares 700,000 Est. Cost $12.88 Unrealized -9.2%

KURA KURA ONCOLOGY INC 2.4%

Value $10.62M Shares 325,000 Est. Cost $26.10 Unrealized +34.6%

— IVERIC BIO INC 2.1%

Value $9.501M Shares 1,375,000 Est. Cost $7.44 Unrealized —

— SURFACE ONCOLOGY INC 2.1%

Value $9.24M Shares 1,000,000 Est. Cost $6.66 Unrealized —

— FIVE PRIME THERAPEUTICS INC 1.9%

Value $8.505M Shares 500,000 Est. Cost $17.01 Unrealized —

SRPT SAREPTA THERAPEUTICS INC 1.5%

Value $6.82M Shares 40,000 Est. Cost $151.97 Unrealized -2.5%

BCRX BIOCRYST PHARMACEUTICALS INC 1.5%

Value $6.705M Shares 900,000 Est. Cost $4.33 Unrealized +18.9%

MLTX HELIX ACQUISITION CORP 1.3%

Value $5.685M Shares 500,000 Est. Cost $11.37 Unrealized —

— VERONA PHARMA PLC 1.3%

Value $5.67M Shares 810,000 Est. Cost $6.24 Unrealized —

— VISTAGEN THERAPEUTICS INC 1.1%

Value $4.734M Shares 2,440,000 Est. Cost $1.94 Unrealized —

ALDX ALDEYRA THERAPEUTICS INC 1.0%

Value $4.459M Shares 650,000 Est. Cost $4.21 Unrealized +66.6%

ACRS ACLARIS THERAPEUTICS INC 0.9%

Value $4.206M Shares 650,000 Est. Cost $4.22 Unrealized 0.0%

IMUX IMMUNIC INC 0.9%

Value $4.052M Shares 265,000 Est. Cost $16.38 Unrealized +9.6%

KALV KALVISTA PHARMACEUTICALS INC 0.8%

Value $3.798M Shares 200,000 Est. Cost $15.74 Unrealized +9.0%

MRNA MODERNA INC 0.8%

Value $3.656M Shares 35,000 Est. Cost $54.76 Unrealized +84.7%

— CURIS INC 0.8%

Value $3.481M Shares 425,000 Est. Cost $8.19 Unrealized —

— SIERRA ONCOLOGY INC 0.7%

Value $3.206M Shares 200,000 Est. Cost $16.03 Unrealized —

— CTI BIOPHARMA CORP 0.5%

Value $2.415M Shares 750,000 Est. Cost $3.22 Unrealized —

— MILLENDO THERAPEUTICS INC 0.4%

Value $1.98M Shares 925,000 Est. Cost $1.63 Unrealized —

— AMARIN CORP PLC 0.4%

Value $1.956M Shares 400,000 Est. Cost $4.72 Unrealized —

— APTEVO THERAPEUTICS INC 0.4%

Value $1.833M Shares 50,000 Est. Cost $36.66 Unrealized —

WVE WAVE LIFE SCIENCES LTD 0.4%

Value $1.574M Shares 200,000 Est. Cost $9.41 Unrealized -10.8%

— OTONOMY INC 0.3%

Value $1.294M Shares 200,000 Est. Cost $6.47 Unrealized —

— SATSUMA PHARMACEUTICALS INC 0.2%

Value $922K Shares 200,000 Est. Cost $26.31 Unrealized —

BIIB BIOGEN INC 0.1%

Value $539K Shares 2,200 Est. Cost $278.91 Unrealized -7.1%

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
QQQ	INVESCO QQQ TR	100,000	$31.37M	7.0%	—	—	Put	46090E103
SNDX	SYNDAX PHARMACEUTICALS INC	1,350,000	$30.02M	6.7%	$18.21	+13.9%	COM	87164F105
—	TRILLIUM THERAPEUTICS INC	1,950,000	$28.68M	6.4%	$7.71	—	COM NEW	89620X506
RCKT	ROCKET PHARMACEUTICALS INC	500,000	$27.42M	6.1%	$19.92	+83.0%	COM	77313F106
IOVA	IOVANCE BIOTHERAPEUTICS INC	500,000	$23.2M	5.2%	$24.73	+60.5%	COM	462260100
APLS	APELLIS PHARMACEUTICALS INC	325,000	$18.59M	4.1%	$42.30	0.0%	COM	03753U106
—	CONSTELLATION PHARMCETICLS I	625,000	$18M	4.0%	$42.72	—	COM	210373106
ASND	ASCENDIS PHARMA A/S	105,000	$17.51M	3.9%	$130.34	—	SPONSORED ADR	04351P101
ARVN	ARVINAS INC	205,000	$17.41M	3.9%	$28.07	+22.8%	COM	04335A105
—	MERSANA THERAPEUTICS INC	600,000	$15.97M	3.6%	$10.98	—	COM	59045L106
FATE	FATE THERAPEUTICS INC	165,000	$15M	3.3%	$25.07	+147.7%	COM	31189P102
IMVT	IMMUNOVANT INC	300,000	$13.86M	3.1%	$11.17	+314.0%	COM	45258J102
FOLD	AMICUS THERAPEUTICS INC	600,000	$13.85M	3.1%	$14.57	+40.3%	COM	03152W109
TGTX	TG THERAPEUTICS INC	250,000	$13.01M	2.9%	$18.29	+84.7%	COM	88322Q108
TVTX	TRAVERE THERAPEUTICS INC	475,000	$12.95M	2.9%	$23.35	0.0%	COM	89422G107
COGT	COGENT BIOSCIENCES INC	1,100,000	$12.35M	2.8%	$10.99	0.0%	COM	19240Q201
—	MIRATI THERAPEUTICS INC	50,000	$10.98M	2.4%	$82.63	—	Call	60468T105
—	MIRATI THERAPEUTICS INC	50,000	$10.98M	2.4%	$82.63	—	COM	60468T105
XENE	XENON PHARMACEUTICALS INC	700,000	$10.77M	2.4%	$12.88	-9.2%	COM	98420N105
KURA	KURA ONCOLOGY INC	325,000	$10.62M	2.4%	$26.10	+34.6%	COM	50127T109
—	IVERIC BIO INC	1,375,000	$9.501M	2.1%	$7.44	—	COM	46583P102
—	SURFACE ONCOLOGY INC	1,000,000	$9.24M	2.1%	$6.66	—	COM	86877M209
—	FIVE PRIME THERAPEUTICS INC	500,000	$8.505M	1.9%	$17.01	—	COM	33830X104
SRPT	SAREPTA THERAPEUTICS INC	40,000	$6.82M	1.5%	$151.97	-2.5%	COM	803607100
BCRX	BIOCRYST PHARMACEUTICALS INC	900,000	$6.705M	1.5%	$4.33	+18.9%	COM	09058V103
MLTX	HELIX ACQUISITION CORP	500,000	$5.685M	1.3%	$11.37	—	COM CL A	G4444C102
—	VERONA PHARMA PLC	810,000	$5.67M	1.3%	$6.24	—	SPONSORED ADS	925050106
—	VISTAGEN THERAPEUTICS INC	2,440,000	$4.734M	1.1%	$1.94	—	COM NEW	92840H202
ALDX	ALDEYRA THERAPEUTICS INC	650,000	$4.459M	1.0%	$4.21	+66.6%	COM	01438T106
ACRS	ACLARIS THERAPEUTICS INC	650,000	$4.206M	0.9%	$4.22	0.0%	COM	00461U105
IMUX	IMMUNIC INC	265,000	$4.052M	0.9%	$16.38	+9.6%	COM	4525EP101
KALV	KALVISTA PHARMACEUTICALS INC	200,000	$3.798M	0.8%	$15.74	+9.0%	COM	483497103
MRNA	MODERNA INC	35,000	$3.656M	0.8%	$54.76	+84.7%	Put	60770K107
—	CURIS INC	425,000	$3.481M	0.8%	$8.19	—	COM NEW	231269200
—	SIERRA ONCOLOGY INC	200,000	$3.206M	0.7%	$16.03	—	COM NEW	82640U404
—	CTI BIOPHARMA CORP	750,000	$2.415M	0.5%	$3.22	—	COM	12648L601
—	MILLENDO THERAPEUTICS INC	925,000	$1.98M	0.4%	$1.63	—	COM	60040X103
—	AMARIN CORP PLC	400,000	$1.956M	0.4%	$4.72	—	SPONS ADR NEW	023111206
—	APTEVO THERAPEUTICS INC	50,000	$1.833M	0.4%	$36.66	—	COM NEW	03835L207
WVE	WAVE LIFE SCIENCES LTD	200,000	$1.574M	0.4%	$9.41	-10.8%	SHS	Y95308105
—	OTONOMY INC	200,000	$1.294M	0.3%	$6.47	—	COM	68906L105
—	SATSUMA PHARMACEUTICALS INC	200,000	$922K	0.2%	$26.31	—	COM	80405P107
BIIB	BIOGEN INC	2,200	$539K	0.1%	$278.91	-7.1%	COM	09062X103