Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
COAG	HEMAB THERAPEUTICS HLDGS INC	4,180,550	$154M	8.9%	—	—	COM SHS	423494103
AVLN	AVALYN PHARMACEUTICALS INC	3,883,289	$128M	7.4%	—	—	COM SHS	05348Y105
FND	FLOOR & DECOR HLDGS INC	797,000	$47.31M	2.7%	—	—	CL A	339750101
ALMS	ALUMIS INC	1,100,000	$30.95M	1.8%	—	—	COM	022307102
DYN	DYNE THERAPEUTICS INC	960,394	$21.33M	1.2%	—	—	COM	26818M108
INSM	INSMED INC	120,723	$12.87M	0.7%	—	—	COM PAR $.01	457669307

Increased Positions (2)

BBOT BRIDGEBIO ONCOLOGY THERAPEUT 1.0%

Value $17.14M (-12.4%) Shares 2,250,000 (+2.9%) Est. Cost — Unrealized —

VRDN VIRIDIAN THERAPEUTICS INC 2.3%

Value $39.22M (+0.3%) Shares 2,135,000 (+6.8%) Est. Cost — Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
BBOT	BRIDGEBIO ONCOLOGY THERAPEUT	2,250,000 (+2.9%)	$17.14M (-12.4%)	1.0%	—	—	COM NEW	107924102
VRDN	VIRIDIAN THERAPEUTICS INC	2,135,000 (+6.8%)	$39.22M (+0.3%)	2.3%	—	—	COM	92790C104

Exited Positions (3)

APGE APOGEE THERAPEUTICS INC 2.2%

Value $37.88M Shares 450,000 Est. Cost — Unrealized —

BMRN BIOMARIN PHARMACEUTICAL INC 2.2%

Value $37.28M Shares 660,000 Est. Cost — Unrealized —

VALN VALNEVA SE 0.4%

Value $6.609M Shares 1,057,421 Est. Cost — Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
APGE	APOGEE THERAPEUTICS INC	450,000	$37.88M	2.2%	—	—	—	03770N101
BMRN	BIOMARIN PHARMACEUTICAL INC	660,000	$37.28M	2.2%	—	—	—	09061G101
VALN	VALNEVA SE	1,057,421	$6.609M	0.4%	—	—	—	92025Y103

Decreased Positions (8)

MIRM MIRUM PHARMACEUTICALS INC 7.6%

Value $132M (+7.6%) Shares 1,125,000 (-15.1%) Est. Cost — Unrealized —

FDMT 4D MOLECULAR THERAPEUTICS IN 2.5%

Value $43.21M (+27.1%) Shares 3,249,178 (-11.0%) Est. Cost — Unrealized —

AVBP ARRIVENT BIOPHARMA INC 3.0%

Value $52.11M (+16.3%) Shares 1,500,000 (-22.8%) Est. Cost — Unrealized —

CRNX CRINETICS PHARMACEUTICALS IN 2.9%

Value $49.39M (-12.3%) Shares 1,320,000 (-14.8%) Est. Cost — Unrealized —

PCVX VAXCYTE INC 2.7%

Value $46.5M (-6.9%) Shares 800,000 (-7.0%) Est. Cost — Unrealized —

PHVS PHARVARIS N V 2.8%

Value $48.41M (-2.1%) Shares 1,400,000 (-20.0%) Est. Cost — Unrealized —

ELVN ENLIVEN THERAPEUTICS INC 2.9%

Value $50.75M (+1.1%) Shares 1,000,000 (-21.9%) Est. Cost — Unrealized —

CLDX CELLDEX THERAPEUTICS INC NEW 2.2%

Value $38.14M (+0.2%) Shares 1,025,000 (-14.6%) Est. Cost — Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
MIRM	MIRUM PHARMACEUTICALS INC	1,125,000 (-15.1%)	$132M (+7.6%)	7.6%	—	—	COM	604749101
FDMT	4D MOLECULAR THERAPEUTICS IN	3,249,178 (-11.0%)	$43.21M (+27.1%)	2.5%	—	—	COM	35104E100
AVBP	ARRIVENT BIOPHARMA INC	1,500,000 (-22.8%)	$52.11M (+16.3%)	3.0%	—	—	COM	04272N102
CRNX	CRINETICS PHARMACEUTICALS IN	1,320,000 (-14.8%)	$49.39M (-12.3%)	2.9%	—	—	COM	22663K107
PCVX	VAXCYTE INC	800,000 (-7.0%)	$46.5M (-6.9%)	2.7%	—	—	COM	92243G108
PHVS	PHARVARIS N V	1,400,000 (-20.0%)	$48.41M (-2.1%)	2.8%	—	—	COM	N69605108
ELVN	ENLIVEN THERAPEUTICS INC	1,000,000 (-21.9%)	$50.75M (+1.1%)	2.9%	—	—	COM	29337E102
CLDX	CELLDEX THERAPEUTICS INC NEW	1,025,000 (-14.6%)	$38.14M (+0.2%)	2.2%	—	—	COM NEW	15117B202

Unchanged Positions (9)

ASML ASML HOLDING N V 11.0%

Value $189M Shares 94,946 Est. Cost — Unrealized —

MPLT MAPLIGHT THERAPEUTICS INC 7.7%

Value $132M Shares 3,686,622 Est. Cost — Unrealized —

EWTX EDGEWISE THERAPEUTICS INC 12.6%

Value $217M Shares 5,350,000 Est. Cost — Unrealized —

CRM SALESFORCE INC 3.6%

Value $61.6M Shares 393,187 Est. Cost — Unrealized —

BN BROOKFIELD CORP 8.7%

Value $150M Shares 3,496,245 Est. Cost — Unrealized —

BABA ALIBABA GROUP HLDG LTD 1.4%

Value $24.7M Shares 257,327 Est. Cost — Unrealized —

MQ MARQETA INC 0.4%

Value $7.171M Shares 441,558 Est. Cost — Unrealized —

LNZA LANZATECH GLOBAL INC 0.1%

Value $1.079M Shares 158,148 Est. Cost — Unrealized —

XENE XENON PHARMACEUTICALS INC 1.7%

Value $29.3M Shares 485,438 Est. Cost — Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
ASML	ASML HOLDING N V	94,946	$189M	11.0%	—	—	N Y REGISTRY SHS	N07059210
MPLT	MAPLIGHT THERAPEUTICS INC	3,686,622	$132M	7.7%	—	—	COM	56565P103
EWTX	EDGEWISE THERAPEUTICS INC	5,350,000	$217M	12.6%	—	—	COM	28036F105
CRM	SALESFORCE INC	393,187	$61.6M	3.6%	—	—	COM	79466L302
BN	BROOKFIELD CORP	3,496,245	$150M	8.7%	—	—	CL A LTD VT SH	11271J107
BABA	ALIBABA GROUP HLDG LTD	257,327	$24.7M	1.4%	—	—	SPONSORED ADS	01609W102
MQ	MARQETA INC	441,558	$7.171M	0.4%	—	—	CLASS A COM	57142B104
LNZA	LANZATECH GLOBAL INC	158,148	$1.079M	0.1%	—	—	COM NEW	51655R200
XENE	XENON PHARMACEUTICALS INC	485,438	$29.3M	1.7%	—	—	COM	98420N105