Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
ABT	Abbott Laboratories	1,400,000	$127M	3.0%	—	—	COM	002824100
ASND	Ascendis Pharma A/S	375,000	$100M	2.3%	—	—	ORD SHS	K08588103
INSM	Insmed Inc	250,000	$26.66M	0.6%	—	—	COM PAR $.01	457669307
TRAX	First Tracks Biotherapeutics I	1,013,000	$20.38M	0.5%	—	—	ORD SHS	337185102
AVTX	Avalo Therapeutics Inc	775,000	$14.32M	0.3%	—	—	COM NEW	05338F306
EVMN	Evommune Inc	1,000,000	$13.29M	0.3%	—	—	COM SHS	30054Y107
KLRA	Kailera Therapeutics Inc	575,000	$12.67M	0.3%	—	—	COMMON STOCK	482931102
IBIO	iBio Inc	2,600,000	$4.55M	0.1%	—	—	COM NEW	451033708
SGMT	Sagimet Biosciences Inc	535,452	$4.139M	0.1%	—	—	COM SER A	786700104
ENGN	enGene Therapeutics Inc	1,667,430	$2.885M	0.1%	—	—	COM	29286X101
RZLT	Rezolute Inc	382,999	$1.992M	0.0%	—	—	COM NEW	76200L309

Increased Positions (30)

UTHR United Therapeutics Corp 5.5%

Value $236M (+430.0%) Shares 435,000 (+480.0%) Est. Cost — Unrealized —

NBIX Neurocrine Biosciences Inc 7.4%

Value $317M (+92.4%) Shares 1,880,000 (+50.4%) Est. Cost — Unrealized —

ABVX Abivax SA 7.3%

Value $313M (+87.4%) Shares 2,349,443 (+56.6%) Est. Cost — Unrealized —

BMRN BioMarin Pharmaceutical Inc 8.1%

Value $345M (+70.7%) Shares 6,025,000 (+68.5%) Est. Cost — Unrealized —

ZBH Zimmer Biomet Holdings Inc 2.8%

Value $121M (+601.6%) Shares 1,400,000 (+636.8%) Est. Cost — Unrealized —

NRIX Nurix Therapeutics Inc 4.6%

Value $195M (+93.8%) Shares 8,050,000 (+23.8%) Est. Cost — Unrealized —

PODD Insulet Corp 2.4%

Value $102M (+860.7%) Shares 670,000 (+1224.1%) Est. Cost — Unrealized —

ELVN Enliven Therapeutics Inc 4.7%

Value $203M (+59.3%) Shares 4,000,000 (+23.1%) Est. Cost — Unrealized —

IRON Disc Medicine Inc 2.6%

Value $113M (+153.3%) Shares 1,550,000 (+121.4%) Est. Cost — Unrealized —

AZN AstraZeneca PLC 2.0%

Value $85.33M (+332.7%) Shares 450,000 (+350.0%) Est. Cost — Unrealized —

TARS Tarsus Pharmaceuticals Inc 1.5%

Value $66.09M (+371.0%) Shares 1,050,000 (+425.0%) Est. Cost — Unrealized —

GLUE Monte Rosa Therapeutics Inc 2.6%

Value $111M (+87.8%) Shares 4,600,000 (+27.7%) Est. Cost — Unrealized —

TSHA Taysha Gene Therapies Inc 3.1%

Value $132M (+64.3%) Shares 19,415,000 (+7.9%) Est. Cost — Unrealized —

NKTR Nektar Therapeutics 1.6%

Value $69.81M (+240.4%) Shares 1,000,000 (+250.9%) Est. Cost — Unrealized —

QURE uniQure NV 1.0%

Value $43.07M (+633.7%) Shares 935,000 (+160.4%) Est. Cost — Unrealized —

TRVI Trevi Therapeutics Inc 1.4%

Value $57.81M (+123.7%) Shares 3,100,000 (+43.1%) Est. Cost — Unrealized —

MYGN Myriad Genetics Inc 0.8%

Value $32.75M (+341.6%) Shares 5,735,000 (+248.0%) Est. Cost — Unrealized —

MDGL Madrigal Pharmaceuticals Inc 0.8%

Value $34.9M (+111.9%) Shares 65,000 (+106.6%) Est. Cost — Unrealized —

SNY Sanofi SA 2.0%

Value $85.32M (+26.5%) Shares 2,000,000 (+42.9%) Est. Cost — Unrealized —

BCRX BioCryst Pharmaceuticals Inc 1.9%

Value $83M (+24.1%) Shares 8,300,000 (+18.1%) Est. Cost — Unrealized —

GMED Globus Medical Inc 1.6%

Value $67.16M (+27.7%) Shares 850,000 (+39.2%) Est. Cost — Unrealized —

GEHC GE HealthCare Technologies Inc 0.7%

Value $28.8M (+61.9%) Shares 450,000 (+80.0%) Est. Cost — Unrealized —

ZBIO Zenas Biopharma Inc 0.2%

Value $9.264M (+136.9%) Shares 365,000 (+82.5%) Est. Cost — Unrealized —

XENE Xenon Pharmaceuticals Inc 1.0%

Value $42.25M (+13.5%) Shares 700,000 (+9.4%) Est. Cost — Unrealized —

TECX Tectonic Therapeutic Inc 0.3%

Value $14.61M (+44.1%) Shares 425,000 (+29.6%) Est. Cost — Unrealized —

ZURA Zura Bio Ltd 0.2%

Value $6.926M (+127.8%) Shares 1,173,956 (+129.7%) Est. Cost — Unrealized —

MNPR Monopar Therapeutics Inc 0.2%

Value $7.012M (+95.6%) Shares 75,727 (+15.8%) Est. Cost — Unrealized —

SVRA Savara Inc 0.4%

Value $16.76M (+18.0%) Shares 2,720,000 (+4.6%) Est. Cost — Unrealized —

DRUG Bright Minds Biosciences Inc 0.9%

Value $38.26M (+6.5%) Shares 545,000 (+10.7%) Est. Cost — Unrealized —

CBIO Crescent Biopharma Inc 0.7%

Value $29.34M (+6.5%) Shares 1,630,000 (+8.7%) Est. Cost — Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
UTHR	United Therapeutics Corp	435,000 (+480.0%)	$236M (+430.0%)	5.5%	—	—	COM	91307C102
NBIX	Neurocrine Biosciences Inc	1,880,000 (+50.4%)	$317M (+92.4%)	7.4%	—	—	COM	64125C109
ABVX	Abivax SA	2,349,443 (+56.6%)	$313M (+87.4%)	7.3%	—	—	SPONSORED ADS	00370M103
BMRN	BioMarin Pharmaceutical Inc	6,025,000 (+68.5%)	$345M (+70.7%)	8.1%	—	—	COM	09061G101
ZBH	Zimmer Biomet Holdings Inc	1,400,000 (+636.8%)	$121M (+601.6%)	2.8%	—	—	COM	98956P102
NRIX	Nurix Therapeutics Inc	8,050,000 (+23.8%)	$195M (+93.8%)	4.6%	—	—	COM	67080M103
PODD	Insulet Corp	670,000 (+1224.1%)	$102M (+860.7%)	2.4%	—	—	COM	45784P101
ELVN	Enliven Therapeutics Inc	4,000,000 (+23.1%)	$203M (+59.3%)	4.7%	—	—	COM	29337E102
IRON	Disc Medicine Inc	1,550,000 (+121.4%)	$113M (+153.3%)	2.6%	—	—	COM	254604101
AZN	AstraZeneca PLC	450,000 (+350.0%)	$85.33M (+332.7%)	2.0%	—	—	ORD	G0593M107
TARS	Tarsus Pharmaceuticals Inc	1,050,000 (+425.0%)	$66.09M (+371.0%)	1.5%	—	—	COM	87650L103
GLUE	Monte Rosa Therapeutics Inc	4,600,000 (+27.7%)	$111M (+87.8%)	2.6%	—	—	COM	61225M102
TSHA	Taysha Gene Therapies Inc	19,415,000 (+7.9%)	$132M (+64.3%)	3.1%	—	—	COM SHS	877619106
NKTR	Nektar Therapeutics	1,000,000 (+250.9%)	$69.81M (+240.4%)	1.6%	—	—	COM NEW	640268306
QURE	uniQure NV	935,000 (+160.4%)	$43.07M (+633.7%)	1.0%	—	—	SHS	N90064101
TRVI	Trevi Therapeutics Inc	3,100,000 (+43.1%)	$57.81M (+123.7%)	1.4%	—	—	COM	89532M101
MYGN	Myriad Genetics Inc	5,735,000 (+248.0%)	$32.75M (+341.6%)	0.8%	—	—	COM	62855J104
MDGL	Madrigal Pharmaceuticals Inc	65,000 (+106.6%)	$34.9M (+111.9%)	0.8%	—	—	COM	558868105
SNY	Sanofi SA	2,000,000 (+42.9%)	$85.32M (+26.5%)	2.0%	—	—	SPONSORED ADR	80105N105
BCRX	BioCryst Pharmaceuticals Inc	8,300,000 (+18.1%)	$83M (+24.1%)	1.9%	—	—	COM	09058V103
GMED	Globus Medical Inc	850,000 (+39.2%)	$67.16M (+27.7%)	1.6%	—	—	CL A	379577208
GEHC	GE HealthCare Technologies Inc	450,000 (+80.0%)	$28.8M (+61.9%)	0.7%	—	—	COMMON STOCK	36266G107
ZBIO	Zenas Biopharma Inc	365,000 (+82.5%)	$9.264M (+136.9%)	0.2%	—	—	COM	98937L105
XENE	Xenon Pharmaceuticals Inc	700,000 (+9.4%)	$42.25M (+13.5%)	1.0%	—	—	COM	98420N105
TECX	Tectonic Therapeutic Inc	425,000 (+29.6%)	$14.61M (+44.1%)	0.3%	—	—	COM	878972108
ZURA	Zura Bio Ltd	1,173,956 (+129.7%)	$6.926M (+127.8%)	0.2%	—	—	CLASS A ORD SHS	G9TY5A101
MNPR	Monopar Therapeutics Inc	75,727 (+15.8%)	$7.012M (+95.6%)	0.2%	—	—	COM NEW	61023L207
SVRA	Savara Inc	2,720,000 (+4.6%)	$16.76M (+18.0%)	0.4%	—	—	COM	805111101
DRUG	Bright Minds Biosciences Inc	545,000 (+10.7%)	$38.26M (+6.5%)	0.9%	—	—	COM NEW	10919W405
CBIO	Crescent Biopharma Inc	1,630,000 (+8.7%)	$29.34M (+6.5%)	0.7%	—	—	COM	G2545C104

Exited Positions (33)

APGE Apogee Therapeutics Inc 2.2%

Value $92.59M Shares 1,100,000 Est. Cost — Unrealized —

ASND Ascendis Pharma A/S 2.0%

Value $85.77M Shares 375,000 Est. Cost — Unrealized —

SRRK Scholar Rock Holding Corp 1.5%

Value $65.11M Shares 1,324,422 Est. Cost — Unrealized —

VERA Vera Therapeutics Inc 1.3%

Value $55.04M Shares 1,368,159 Est. Cost — Unrealized —

TERN Terns Pharmaceuticals Inc 1.2%

Value $52.72M Shares 1,000,000 Est. Cost — Unrealized —

BSX Boston Scientific Corp 1.2%

Value $50.2M Shares 800,000 Est. Cost — Unrealized —

NUVL Nuvalent Inc 1.2%

Value $49.35M Shares 481,715 Est. Cost — Unrealized —

COGT Cogent Biosciences Inc 1.1%

Value $47.38M Shares 1,230,888 Est. Cost — Unrealized —

CLDX Celldex Therapeutics Inc 0.9%

Value $38.83M Shares 1,224,165 Est. Cost — Unrealized —

KALV KalVista Pharmaceuticals Inc 0.9%

Value $37.24M Shares 1,850,000 Est. Cost — Unrealized —

PTGX Protagonist Therapeutics Inc 0.8%

Value $34.38M Shares 326,159 Est. Cost — Unrealized —

DNLI Denali Therapeutics Inc 0.8%

Value $34.05M Shares 1,773,326 Est. Cost — Unrealized —

WAT Waters Corp 0.7%

Value $29.78M Shares 100,000 Est. Cost — Unrealized —

INSP Inspire Medical Systems Inc 0.6%

Value $27.82M Shares 539,269 Est. Cost — Unrealized —

SLNO Soleno Therapeutics Inc 0.6%

Value $24.44M Shares 730,000 Est. Cost — Unrealized —

CYTK Cytokinetics Inc 0.5%

Value $19.77M Shares 300,000 Est. Cost — Unrealized —

WST West Pharmaceutical Services I 0.4%

Value $18.8M Shares 75,000 Est. Cost — Unrealized —

WGS GeneDx Holdings Corp 0.4%

Value $16.05M Shares 250,000 Est. Cost — Unrealized —

AGIO Agios Pharmaceuticals Inc 0.4%

Value $15.22M Shares 450,000 Est. Cost — Unrealized —

ENGN enGene Therapeutics Inc 0.3%

Value $14.74M Shares 2,165,000 Est. Cost — Unrealized —

ARVN Arvinas Inc 0.2%

Value $9.598M Shares 905,465 Est. Cost — Unrealized —

MPLT MapLight Therapeutics Inc 0.2%

Value $8.539M Shares 420,000 Est. Cost — Unrealized —

FULC Fulcrum Therapeutics Inc 0.2%

Value $8.437M Shares 1,100,000 Est. Cost — Unrealized —

CADL Candel Therapeutics Inc 0.1%

Value $5.513M Shares 1,125,000 Est. Cost — Unrealized —

VCYT Veracyte Inc 0.1%

Value $4.209M Shares 130,687 Est. Cost — Unrealized —

GERN Geron Corp 0.1%

Value $3.785M Shares 2,540,000 Est. Cost — Unrealized —

NVCR Novocure Ltd 0.1%

Value $2.725M Shares 250,000 Est. Cost — Unrealized —

URGN UroGen Pharma Ltd 0.1%

Value $2.501M Shares 139,079 Est. Cost — Unrealized —

PASG Passage Bio Inc 0.1%

Value $2.394M Shares 305,000 Est. Cost — Unrealized —

TYRA Tyra Biosciences Inc 0.0%

Value $2.068M Shares 54,000 Est. Cost — Unrealized —

RGNX REGENXBIO Inc 0.0%

Value $909K Shares 108,525 Est. Cost — Unrealized —

MGNX MacroGenics Inc 0.0%

Value $809K Shares 280,000 Est. Cost — Unrealized —

ABSI Absci Corp 0.0%

Value $697K Shares 232,219 Est. Cost — Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
APGE	Apogee Therapeutics Inc	1,100,000	$92.59M	2.2%	—	—	—	03770N101
ASND	Ascendis Pharma A/S	375,000	$85.77M	2.0%	—	—	—	04351P101
SRRK	Scholar Rock Holding Corp	1,324,422	$65.11M	1.5%	—	—	—	80706P103
VERA	Vera Therapeutics Inc	1,368,159	$55.04M	1.3%	—	—	—	92337R101
TERN	Terns Pharmaceuticals Inc	1,000,000	$52.72M	1.2%	—	—	—	880881107
BSX	Boston Scientific Corp	800,000	$50.2M	1.2%	—	—	—	101137107
NUVL	Nuvalent Inc	481,715	$49.35M	1.2%	—	—	—	670703107
COGT	Cogent Biosciences Inc	1,230,888	$47.38M	1.1%	—	—	—	19240Q201
CLDX	Celldex Therapeutics Inc	1,224,165	$38.83M	0.9%	—	—	—	15117B202
KALV	KalVista Pharmaceuticals Inc	1,850,000	$37.24M	0.9%	—	—	—	483497103
PTGX	Protagonist Therapeutics Inc	326,159	$34.38M	0.8%	—	—	—	74366E102
DNLI	Denali Therapeutics Inc	1,773,326	$34.05M	0.8%	—	—	—	24823R105
WAT	Waters Corp	100,000	$29.78M	0.7%	—	—	—	941848103
INSP	Inspire Medical Systems Inc	539,269	$27.82M	0.6%	—	—	—	457730109
SLNO	Soleno Therapeutics Inc	730,000	$24.44M	0.6%	—	—	—	834203309
CYTK	Cytokinetics Inc	300,000	$19.77M	0.5%	—	—	—	23282W605
WST	West Pharmaceutical Services I	75,000	$18.8M	0.4%	—	—	—	955306105
WGS	GeneDx Holdings Corp	250,000	$16.05M	0.4%	—	—	—	81663L200
AGIO	Agios Pharmaceuticals Inc	450,000	$15.22M	0.4%	—	—	—	00847X104
ENGN	enGene Therapeutics Inc	2,165,000	$14.74M	0.3%	—	—	—	29286M105
ARVN	Arvinas Inc	905,465	$9.598M	0.2%	—	—	—	04335A105
MPLT	MapLight Therapeutics Inc	420,000	$8.539M	0.2%	—	—	—	56565P103
FULC	Fulcrum Therapeutics Inc	1,100,000	$8.437M	0.2%	—	—	—	359616109
CADL	Candel Therapeutics Inc	1,125,000	$5.513M	0.1%	—	—	—	137404109
VCYT	Veracyte Inc	130,687	$4.209M	0.1%	—	—	—	92337F107
GERN	Geron Corp	2,540,000	$3.785M	0.1%	—	—	—	374163103
NVCR	Novocure Ltd	250,000	$2.725M	0.1%	—	—	—	G6674U108
URGN	UroGen Pharma Ltd	139,079	$2.501M	0.1%	—	—	—	M96088105
PASG	Passage Bio Inc	305,000	$2.394M	0.1%	—	—	—	702712209
TYRA	Tyra Biosciences Inc	54,000	$2.068M	0.0%	—	—	—	90240B106
RGNX	REGENXBIO Inc	108,525	$909K	0.0%	—	—	—	75901B107
MGNX	MacroGenics Inc	280,000	$809K	0.0%	—	—	—	556099109
ABSI	Absci Corp	232,219	$697K	0.0%	—	—	—	00091E109

Decreased Positions (20)

RVMD Revolution Medicines Inc 2.0%

Value $84.28M (-63.5%) Shares 450,000 (-81.1%) Est. Cost — Unrealized —

RGEN Repligen Corp 1.3%

Value $54.58M (-49.9%) Shares 400,000 (-56.8%) Est. Cost — Unrealized —

BCAX Bicara Therapeutics Inc 3.6%

Value $156M (+44.5%) Shares 5,250,000 (-3.2%) Est. Cost — Unrealized —

ALC Alcon AG 0.8%

Value $33.55M (-44.3%) Shares 500,000 (-37.5%) Est. Cost — Unrealized —

IMCR Immunocore Holdings PLC 1.3%

Value $57.15M (-31.5%) Shares 1,800,000 (-34.9%) Est. Cost — Unrealized —

ANRO Alto Neuroscience Inc 0.5%

Value $20.72M (-55.4%) Shares 785,000 (-62.0%) Est. Cost — Unrealized —

BMY Bristol-Myers Squibb Co 1.1%

Value $46.1M (-24.0%) Shares 800,000 (-20.0%) Est. Cost — Unrealized —

RAPP Rapport Therapeutics Inc 0.7%

Value $30.42M (-32.3%) Shares 730,000 (-49.2%) Est. Cost — Unrealized —

SLDB Solid Biosciences Inc 0.5%

Value $21.58M (-40.1%) Shares 2,160,000 (-56.8%) Est. Cost — Unrealized —

ARWR Arrowhead Pharmaceuticals Inc 3.0%

Value $128M (-10.0%) Shares 1,575,000 (-30.8%) Est. Cost — Unrealized —

LXEO Lexeo Therapeutics Inc 0.5%

Value $20.11M (-21.7%) Shares 4,320,000 (-3.5%) Est. Cost — Unrealized —

AVR Anteris Technologies Global Co 0.2%

Value $9.948M (+56.6%) Shares 1,010,000 (-11.8%) Est. Cost — Unrealized —

VKTX Viking Therapeutics Inc 0.6%

Value $26.53M (-10.8%) Shares 680,000 (-25.6%) Est. Cost — Unrealized —

BBNX Beta Bionics Inc 0.6%

Value $25.07M (+13.1%) Shares 1,600,000 (-27.7%) Est. Cost — Unrealized —

DYN Dyne Therapeutics Inc 1.8%

Value $74.96M (+3.4%) Shares 3,375,000 (-15.6%) Est. Cost — Unrealized —

VYGR Voyager Therapeutics Inc 0.2%

Value $9.188M (-20.7%) Shares 2,625,000 (-12.6%) Est. Cost — Unrealized —

SRZN Surrozen Inc 0.2%

Value $7.906M (-19.8%) Shares 304,669 (-10.0%) Est. Cost — Unrealized —

OLMA Olema Pharmaceuticals Inc 0.1%

Value $5.236M (-18.1%) Shares 418,551 (-2.3%) Est. Cost — Unrealized —

NYXH Nyxoah SA 0.0%

Value $1.425M (-43.8%) Shares 843,461 (-2.9%) Est. Cost — Unrealized —

GLTO Damora Therapeutics Inc 0.3%

Value $14.96M (-3.8%) Shares 575,000 (-4.2%) Est. Cost — Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
RVMD	Revolution Medicines Inc	450,000 (-81.1%)	$84.28M (-63.5%)	2.0%	—	—	COM	76155X100
RGEN	Repligen Corp	400,000 (-56.8%)	$54.58M (-49.9%)	1.3%	—	—	COM	759916109
BCAX	Bicara Therapeutics Inc	5,250,000 (-3.2%)	$156M (+44.5%)	3.6%	—	—	COM	055477103
ALC	Alcon AG	500,000 (-37.5%)	$33.55M (-44.3%)	0.8%	—	—	ORD SHS	H01301128
IMCR	Immunocore Holdings PLC	1,800,000 (-34.9%)	$57.15M (-31.5%)	1.3%	—	—	ADS	45258D105
ANRO	Alto Neuroscience Inc	785,000 (-62.0%)	$20.72M (-55.4%)	0.5%	—	—	COM SHS	02157Q109
BMY	Bristol-Myers Squibb Co	800,000 (-20.0%)	$46.1M (-24.0%)	1.1%	—	—	COM	110122108
RAPP	Rapport Therapeutics Inc	730,000 (-49.2%)	$30.42M (-32.3%)	0.7%	—	—	COM	75383L102
SLDB	Solid Biosciences Inc	2,160,000 (-56.8%)	$21.58M (-40.1%)	0.5%	—	—	COM NEW	83422E204
ARWR	Arrowhead Pharmaceuticals Inc	1,575,000 (-30.8%)	$128M (-10.0%)	3.0%	—	—	COM	04280A100
LXEO	Lexeo Therapeutics Inc	4,320,000 (-3.5%)	$20.11M (-21.7%)	0.5%	—	—	COM	52886X107
AVR	Anteris Technologies Global Co	1,010,000 (-11.8%)	$9.948M (+56.6%)	0.2%	—	—	COM	03675P102
VKTX	Viking Therapeutics Inc	680,000 (-25.6%)	$26.53M (-10.8%)	0.6%	—	—	COM	92686J106
BBNX	Beta Bionics Inc	1,600,000 (-27.7%)	$25.07M (+13.1%)	0.6%	—	—	COM	08659B102
DYN	Dyne Therapeutics Inc	3,375,000 (-15.6%)	$74.96M (+3.4%)	1.8%	—	—	COM	26818M108
VYGR	Voyager Therapeutics Inc	2,625,000 (-12.6%)	$9.188M (-20.7%)	0.2%	—	—	COM	92915B106
SRZN	Surrozen Inc	304,669 (-10.0%)	$7.906M (-19.8%)	0.2%	—	—	COM NEW	86889P208
OLMA	Olema Pharmaceuticals Inc	418,551 (-2.3%)	$5.236M (-18.1%)	0.1%	—	—	COM	68062P106
NYXH	Nyxoah SA	843,461 (-2.9%)	$1.425M (-43.8%)	0.0%	—	—	SHS	B6S7WD106
GLTO	Damora Therapeutics Inc	575,000 (-4.2%)	$14.96M (-3.8%)	0.3%	—	—	COM NEW	36322Q206

Unchanged Positions (7)

REGN Regeneron Pharmaceuticals Inc 0.6%

Value $24.94M Shares 40,000 Est. Cost — Unrealized —

SGP SpyGlass Pharma Inc 0.3%

Value $14.91M Shares 670,000 Est. Cost — Unrealized —

IMTX Immatics NV 1.5%

Value $62.55M Shares 6,175,000 Est. Cost — Unrealized —

PALI Palisade Bio Inc 0.1%

Value $5.225M Shares 2,500,000 Est. Cost — Unrealized —

OKUR OnKure Therapeutics Inc 0.2%

Value $8.325M Shares 1,825,699 Est. Cost — Unrealized —

TENX Tenax Therapeutics Inc 0.0%

Value $778K Shares 53,439 Est. Cost — Unrealized —

APRE Aprea Therapeutics Inc 0.0%

Value $281K Shares 350,000 Est. Cost — Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
REGN	Regeneron Pharmaceuticals Inc	40,000	$24.94M	0.6%	—	—	COM	75886F107
SGP	SpyGlass Pharma Inc	670,000	$14.91M	0.3%	—	—	COM SHS	85220G109
IMTX	Immatics NV	6,175,000	$62.55M	1.5%	—	—	SHS	N44445109
PALI	Palisade Bio Inc	2,500,000	$5.225M	0.1%	—	—	COM	696389402
OKUR	OnKure Therapeutics Inc	1,825,699	$8.325M	0.2%	—	—	COM CL A	68277Q105
TENX	Tenax Therapeutics Inc	53,439	$778K	0.0%	—	—	COM NEW	88032L605
APRE	Aprea Therapeutics Inc	350,000	$281K	0.0%	—	—	COM NEW	03836J201