Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
DFTX	DEFINIUM THERAPEUTICS INC	1,738,110	$32.85M	7.5%	—	—	COM SHS	24477V105
RVMD	REVOLUTION MEDICINES INC	245,000	$23.83M	5.5%	—	—	COM	76155X100
CYTK	CYTOKINETICS INC	300,000	$19.77M	4.5%	—	—	COM NEW	23282W605
SNDX	SYNDAX PHARMACEUTICALS INC	701,821	$16.39M	3.8%	—	—	COM	87164F105
FDMT	4D MOLECULAR THERAPEUTICS IN	1,302,917	$12.13M	2.8%	—	—	COM	35104E100
XENE	XENON PHARMACEUTICALS INC	200,000	$11.63M	2.7%	—	—	PUT	98420N105
DSGN	DESIGN THERAPEUTICS INC	852,013	$9.065M	2.1%	—	—	COM	25056L103
NERV	MINERVA NEUROSCIENCES INC	1,419,000	$8.549M	2.0%	—	—	COM NEW	603380205
PMN	PROMIS NEUROSCIENCES INC	557,103	$7.075M	1.6%	—	—	COM SHS	74346M505
SLGL	SOL-GEL TECHNOLOGIES LTD	85,496	$6.773M	1.6%	—	—	SHS NEW	M8694L137
IPSC	CENTURY THERAPEUTICS INC	2,449,993	$5.537M	1.3%	—	—	COM	15673T100
SNSE	SENSEI BIOTHERAPEUTICS INC	125,000	$3.94M	0.9%	—	—	COM NEW	81728A207
IRD	OPUS GENETICS INC	500,000	$2.275M	0.5%	—	—	COM	67577R102

Increased Positions (4)

MIRM MIRUM PHARMACEUTICALS INC 7.1%

Value $30.79M (+1123.4%) Shares 333,312 (+946.1%) Est. Cost — Unrealized —

IMVT IMMUNOVANT INC 2.4%

Value $10.29M (+68.5%) Shares 414,054 (+72.4%) Est. Cost — Unrealized —

IKT INHIBIKASE THERAPEUTICS INC 3.1%

Value $13.54M (+6.9%) Shares 8,057,345 (+30.4%) Est. Cost — Unrealized —

RCUS ARCUS BIOSCIENCES INC 5.2%

Value $22.64M (+3.7%) Shares 1,047,935 (+14.4%) Est. Cost — Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
MIRM	MIRUM PHARMACEUTICALS INC	333,312 (+946.1%)	$30.79M (+1123.4%)	7.1%	—	—	COM	604749101
IMVT	IMMUNOVANT INC	414,054 (+72.4%)	$10.29M (+68.5%)	2.4%	—	—	COM	45258J102
IKT	INHIBIKASE THERAPEUTICS INC	8,057,345 (+30.4%)	$13.54M (+6.9%)	3.1%	—	—	COM NEW	45719W205
RCUS	ARCUS BIOSCIENCES INC	1,047,935 (+14.4%)	$22.64M (+3.7%)	5.2%	—	—	COM	03969F109

Exited Positions (9)

ACAD ACADIA PHARMACEUTICALS INC 8.7%

Value $37.91M Shares 1,419,406 Est. Cost — Unrealized —

— MIND MEDICINE MINDMED INC 7.9%

Value $34.39M Shares 2,568,110 Est. Cost — Unrealized —

TYRA TYRA BIOSCIENCES INC 4.2%

Value $18.4M Shares 700,000 Est. Cost — Unrealized —

FOLD AMICUS THERAPEUTICS INC 3.4%

Value $14.86M Shares 1,043,313 Est. Cost — Unrealized —

APGE APOGEE THERAPEUTICS INC 3.3%

Value $14.49M Shares 192,000 Est. Cost — Unrealized —

TERN TERNS PHARMACEUTICALS INC 2.8%

Value $12.12M Shares 300,000 Est. Cost — Unrealized —

MBX MBX BIOSCIENCES INC 2.3%

Value $9.94M Shares 315,158 Est. Cost — Unrealized —

CMPX COMPASS THERAPEUTICS INC 1.7%

Value $7.6M Shares 1,415,273 Est. Cost — Unrealized —

ELVN ENLIVEN THERAPEUTICS INC 0.7%

Value $3.069M Shares 199,306 Est. Cost — Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
ACAD	ACADIA PHARMACEUTICALS INC	1,419,406	$37.91M	8.7%	—	—	—	004225108
—	MIND MEDICINE MINDMED INC	2,568,110	$34.39M	7.9%	—	—	—	60255C885
TYRA	TYRA BIOSCIENCES INC	700,000	$18.4M	4.2%	—	—	—	90240B106
FOLD	AMICUS THERAPEUTICS INC	1,043,313	$14.86M	3.4%	—	—	—	03152W109
APGE	APOGEE THERAPEUTICS INC	192,000	$14.49M	3.3%	—	—	—	03770N101
TERN	TERNS PHARMACEUTICALS INC	300,000	$12.12M	2.8%	—	—	—	880881107
MBX	MBX BIOSCIENCES INC	315,158	$9.94M	2.3%	—	—	—	55287L101
CMPX	COMPASS THERAPEUTICS INC	1,415,273	$7.6M	1.7%	—	—	—	20454B104
ELVN	ENLIVEN THERAPEUTICS INC	199,306	$3.069M	0.7%	—	—	—	29337E102

Decreased Positions (5)

PCVX VAXCYTE INC 8.8%

Value $38.5M (+13.1%) Shares 662,470 (-10.2%) Est. Cost — Unrealized —

VTVT VTV THERAPEUTICS INC 1.3%

Value $5.536M (-40.1%) Shares 139,578 (-39.6%) Est. Cost — Unrealized —

CAMP CAMP4 THERAPEUTICS CORP 2.0%

Value $8.553M (-29.7%) Shares 1,939,563 (-2.2%) Est. Cost — Unrealized —

LBRX LB PHARMACEUTICALS INC 7.5%

Value $32.54M (+4.7%) Shares 1,319,362 (-5.5%) Est. Cost — Unrealized —

XENE XENON PHARMACEUTICALS INC 5.9%

Value $25.59M (-4.4%) Shares 440,000 (-26.3%) Est. Cost — Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
PCVX	VAXCYTE INC	662,470 (-10.2%)	$38.5M (+13.1%)	8.8%	—	—	COM	92243G108
VTVT	VTV THERAPEUTICS INC	139,578 (-39.6%)	$5.536M (-40.1%)	1.3%	—	—	CL A NEW	918385204
CAMP	CAMP4 THERAPEUTICS CORP	1,939,563 (-2.2%)	$8.553M (-29.7%)	2.0%	—	—	COM	13463J101
LBRX	LB PHARMACEUTICALS INC	1,319,362 (-5.5%)	$32.54M (+4.7%)	7.5%	—	—	COM SHS	50180M108
XENE	XENON PHARMACEUTICALS INC	440,000 (-26.3%)	$25.59M (-4.4%)	5.9%	—	—	COM	98420N105

Unchanged Positions (5)

NRIX NURIX THERAPEUTICS INC 6.2%

Value $27.02M Shares 1,743,220 Est. Cost — Unrealized —

IMCR IMMUNOCORE HLDGS PLC 4.7%

Value $20.58M Shares 682,597 Est. Cost — Unrealized —

IVA INVENTIVA SA 3.4%

Value $14.75M Shares 2,657,997 Est. Cost — Unrealized —

NGNE NEUROGENE INC 3.6%

Value $15.78M Shares 782,787 Est. Cost — Unrealized —

XFOR X4 PHARMACEUTICALS INC 2.4%

Value $10.62M Shares 2,571,478 Est. Cost — Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
NRIX	NURIX THERAPEUTICS INC	1,743,220	$27.02M	6.2%	—	—	COM	67080M103
IMCR	IMMUNOCORE HLDGS PLC	682,597	$20.58M	4.7%	—	—	ADS	45258D105
IVA	INVENTIVA SA	2,657,997	$14.75M	3.4%	—	—	ADS	46124U107
NGNE	NEUROGENE INC	782,787	$15.78M	3.6%	—	—	COM	64135M105
XFOR	X4 PHARMACEUTICALS INC	2,571,478	$10.62M	2.4%	—	—	COM NEW	98420X202