Mass General Brigham, Inc Quant / Systematic

CIK: 0001678378 · Show all filings

Period: Q4 2025 (← Previous)

Filing Date: Jan 27, 2026

Total Value ($000): $809,787 (100.0% shares, 0.0% debt)

Holdings (7)

New Positions (5)

ACWI ISHARES TR 80.6%

Value ($000) $652,828 Shares 4,613,955 Est. Cost $141.49 Unrealized —

KRMN KARMAN HLDGS INC 14.1%

Value ($000) $114,295 Shares 1,562,054 Est. Cost $72.41 Unrealized 0.0%

MAZE MAZE THERAPEUTICS INC 1.2%

Value ($000) $9,943 Shares 239,994 Est. Cost $34.37 Unrealized 0.0%

MDLN MEDLINE INC 0.1%

Value ($000) $1,104 Shares 26,294 Est. Cost $42.23 Unrealized 0.0%

RBRK RUBRIK INC 0.1%

Value ($000) $1,071 Shares 14,000 Est. Cost $76.71 Unrealized 0.0%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
ACWI	ISHARES TR	4,613,955	$652,828	80.6%	$141.49	—	MSCI ACWI ETF	464288257
KRMN	KARMAN HLDGS INC	1,562,054	$114,295	14.1%	$72.41	0.0%	COM	485924104
MAZE	MAZE THERAPEUTICS INC	239,994	$9,943	1.2%	$34.37	0.0%	COM	578784100
MDLN	MEDLINE INC	26,294	$1,104	0.1%	$42.23	0.0%	COM	58507V107
RBRK	RUBRIK INC	14,000	$1,071	0.1%	$76.71	0.0%	COM	781154109

Increased Positions (1)

RVMD REVOLUTION MEDICINES INC 3.4%

Value ($000) $27,407 (+78.7%) Shares 344,091 (+1.7%) Est. Cost $30.26 Unrealized +116.7%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
RVMD	REVOLUTION MEDICINES INC	344,091 (+1.7%)	$27,407 (+78.7%)	3.4%	$30.26	+116.7%	COM	76155X100

Exited Positions (3)

IOT SAMSARA INC 2.7%

Value ($000) $21,594 Shares 448,753 Est. Cost $40.53 Unrealized -4.5%

PLRX PLIANT THERAPEUTICS INC 0.4%

Value ($000) $3,236 Shares 288,690 Est. Cost $16.49 Unrealized -90.9%

FULC FULCRUM THERAPEUTICS INC 0.1%

Value ($000) $733 Shares 205,356 Est. Cost $8.93 Unrealized +14.0%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
IOT	SAMSARA INC	448,753	$21,594	2.7%	$40.53	-4.5%	—	79589L106
PLRX	PLIANT THERAPEUTICS INC	288,690	$3,236	0.4%	$16.49	-90.9%	—	729139105
FULC	FULCRUM THERAPEUTICS INC	205,356	$733	0.1%	$8.93	+14.0%	—	359616109

Unchanged Positions (1)

TNGX TANGO THERAPEUTICS INC 0.4%

Value ($000) $3,138 Shares 354,192 Est. Cost $10.72 Unrealized -19.6%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
TNGX	TANGO THERAPEUTICS INC	354,192	$3,138	0.4%	$10.72	-19.6%	COM	87583X109