Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
PLRX	PLIANT THERAPEUTICS INC	1,798,070	$2.05M	0.4%	$1.14	—	COM	729139105
FHTX	FOGHORN THERAPEUTICS INC	61,588	$301K	0.1%	$4.88	—	COM	344174107
AVTX	AVALO THERAPEUTICS INC	10,100	$187K	0.0%	$18.48	—	COM NEW	05338F306
NUVB	NUVATION BIO INC	16,029	$91,045	0.0%	$5.68	—	COM CL A	67080N101
EPRX	EUPRAXIA PHARMACEUTICALS INC	10,000	$66,100	0.0%	$6.61	—	COM	29842P105
IKT	INHIBIKASE THERAPEUTICS INC	20,000	$40,600	0.0%	$2.03	—	COM NEW	45719W205

Increased Positions (4)

AGIO AGIOS PHARMACEUTICALS INC 24.9%

Value $127M (+43.2%) Shares 3,408,937 (+30.5%) Est. Cost $30.32 Unrealized —

CCCC C4 THERAPEUTICS INC 6.7%

Value $34.22M (+85.9%) Shares 7,326,691 (+4.7%) Est. Cost $4.48 Unrealized —

PASG PASSAGE BIO INC 0.6%

Value $3.288M (-32.8%) Shares 673,759 (+8.0%) Est. Cost $6.81 Unrealized —

TRAW TRAWS PHARMA INC 0.1%

Value $472K (+1609.9%) Shares 559,470 (+3610.5%) Est. Cost $0.87 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
AGIO	AGIOS PHARMACEUTICALS INC	3,408,937 (+30.5%)	$127M (+43.2%)	24.9%	$30.32	—	COM	00847X104
CCCC	C4 THERAPEUTICS INC	7,326,691 (+4.7%)	$34.22M (+85.9%)	6.7%	$4.48	—	COM STK	12529R107
PASG	PASSAGE BIO INC	673,759 (+8.0%)	$3.288M (-32.8%)	0.6%	$6.81	—	COM NEW	702712209
TRAW	TRAWS PHARMA INC	559,470 (+3610.5%)	$472K (+1609.9%)	0.1%	$0.87	—	COM NEW	68232V884

Exited Positions (6)

GHRS GH RESEARCH PLC 29.8%

Value $151M Shares 10,763,288 Est. Cost $11.25 Unrealized —

IMTX IMMATICS N.V 0.4%

Value $2.135M Shares 216,973 Est. Cost $10.09 Unrealized —

DSGN DESIGN THERAPEUTICS INC 0.3%

Value $1.272M Shares 119,516 Est. Cost $7.04 Unrealized —

IBIO IBIO INC 0.0%

Value $129K Shares 68,076 Est. Cost $2.31 Unrealized —

PRQR PROQR THRAPEUTICS N V 0.0%

Value $111K Shares 68,486 Est. Cost $2.34 Unrealized —

ABSI ABSCI CORPORATION 0.0%

Value $63,735 Shares 21,245 Est. Cost $3.00 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
GHRS	GH RESEARCH PLC	10,763,288	$151M	29.8%	$11.25	—	—	G3855L106
IMTX	IMMATICS N.V	216,973	$2.135M	0.4%	$10.09	—	—	N44445109
DSGN	DESIGN THERAPEUTICS INC	119,516	$1.272M	0.3%	$7.04	—	—	25056L103
IBIO	IBIO INC	68,076	$129K	0.0%	$2.31	—	—	451033708
PRQR	PROQR THRAPEUTICS N V	68,486	$111K	0.0%	$2.34	—	—	N71542109
ABSI	ABSCI CORPORATION	21,245	$63,735	0.0%	$3.00	—	—	00091E109

Decreased Positions (5)

DNLI DENALI THERAPEUTICS INC 0.1%

Value $300K (-99.2%) Shares 11,658 (-99.4%) Est. Cost $16.74 Unrealized —

STOK STOKE THERAPEUTICS INC 26.0%

Value $132M (-14.8%) Shares 4,038,404 (-15.2%) Est. Cost $8.00 Unrealized —

XNCR XENCOR INC 0.1%

Value $293K (-95.5%) Shares 18,194 (-96.6%) Est. Cost $14.94 Unrealized —

DTIL PRECISION BIOSCIENCES INC 1.5%

Value $7.471M (+37.9%) Shares 950,466 (-3.5%) Est. Cost $6.69 Unrealized —

TRDA ENTRADA THERAPEUTICS INC 0.3%

Value $1.315M (-50.8%) Shares 178,606 (-15.6%) Est. Cost $12.05 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
DNLI	DENALI THERAPEUTICS INC	11,658 (-99.4%)	$300K (-99.2%)	0.1%	$16.74	—	COM	24823R105
STOK	STOKE THERAPEUTICS INC	4,038,404 (-15.2%)	$132M (-14.8%)	26.0%	$8.00	—	COM	86150R107
XNCR	XENCOR INC	18,194 (-96.6%)	$293K (-95.5%)	0.1%	$14.94	—	COM	98401F105
DTIL	PRECISION BIOSCIENCES INC	950,466 (-3.5%)	$7.471M (+37.9%)	1.5%	$6.69	—	COM NEW	74019P207
TRDA	ENTRADA THERAPEUTICS INC	178,606 (-15.6%)	$1.315M (-50.8%)	0.3%	$12.05	—	COM	29384C108

Unchanged Positions (8)

CGEM CULLINAN THERAPEUTICS INC 32.2%

Value $163M Shares 8,963,500 Est. Cost $9.81 Unrealized —

KRRO KORRO BIO INC 4.0%

Value $20.27M Shares 1,538,296 Est. Cost $16.34 Unrealized —

HOWL WEREWOLF THERAPEUTICS INC 0.0%

Value $237K Shares 657,786 Est. Cost $1.22 Unrealized —

NEUP NEUPHORIA THERAPEUTICS INC 0.8%

Value $3.825M Shares 875,328 Est. Cost $7.10 Unrealized —

TCRX TSCAN THERAPEUTICS INC 1.5%

Value $7.86M Shares 8,019,148 Est. Cost $2.30 Unrealized —

CGON CG ONCOLOGY INC 0.4%

Value $2.23M Shares 31,391 Est. Cost $41.38 Unrealized —

VYNE VYNE THERAPEUTICS INC 0.2%

Value $1.06M Shares 1,628,700 Est. Cost $0.57 Unrealized —

BOLT BOLT BIOTHERAPEUTICS INC 0.0%

Value $119K Shares 30,800 Est. Cost $5.73 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
CGEM	CULLINAN THERAPEUTICS INC	8,963,500	$163M	32.2%	$9.81	—	COM	230031106
KRRO	KORRO BIO INC	1,538,296	$20.27M	4.0%	$16.34	—	COM	500946108
HOWL	WEREWOLF THERAPEUTICS INC	657,786	$237K	0.0%	$1.22	—	COM	95075A107
NEUP	NEUPHORIA THERAPEUTICS INC	875,328	$3.825M	0.8%	$7.10	—	COM	64136E102
TCRX	TSCAN THERAPEUTICS INC	8,019,148	$7.86M	1.5%	$2.30	—	COM	89854M101
CGON	CG ONCOLOGY INC	31,391	$2.23M	0.4%	$41.38	—	COM	156944100
VYNE	VYNE THERAPEUTICS INC	1,628,700	$1.06M	0.2%	$0.57	—	COM	92941V308
BOLT	BOLT BIOTHERAPEUTICS INC	30,800	$119K	0.0%	$5.73	—	COM NEW	097702203