Boxer Capital Management, LLC Quant / Systematic

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
TERN	TERNS PHARMACEUTICALS INC	375,000	$15,150	3.3%	$23.11	0.0%	COM	880881107
PRAX	PRAXIS PRECISION MEDICINES I	46,457	$13,693	3.0%	$186.22	0.0%	COM NEW	74006W207
PALI	PALISADE BIO INC	4,799,875	$11,280	2.5%	$1.92	0.0%	COM	696389402
SRZN	SURROZEN INC	416,150	$9,405	2.1%	$16.18	0.0%	COM NEW	86889P208
CAPR	CAPRICOR THERAPEUTICS INC	325,000	$9,380	2.1%	$13.06	0.0%	COM NEW	14070B309
COGT	COGENT BIOSCIENCES INC	225,000	$7,992	1.7%	$28.11	0.0%	COM	19240Q201
HELP	CYBIN INC	715,000	$5,849	1.3%	$6.44	0.0%	COM NEW	23256X407
CTNM	CONTINEUM THERAPEUTICS INC	494,000	$5,646	1.2%	$11.41	0.0%	CL A	21217B100
GPCR	STRUCTURE THERAPEUTICS INC	75,000	$5,216	1.1%	$69.55	—	SPONSORED ADS	86366E106
UPB	UPSTREAM BIO INC	150,000	$4,073	0.9%	$24.89	0.0%	COM	91678A107
VIR	VIR BIOTECHNOLOGY INC	625,000	$3,769	0.8%	$5.95	0.0%	COM	92764N102
IVVD	INVIVYD INC	1,500,000	$3,705	0.8%	$2.08	0.0%	COM	00534A102
KPTI	KARYOPHARM THERAPEUTICS INC	252,536	$1,859	0.4%	$6.12	0.0%	COM NEW	48576U205
CLNN	CLENE INC	199,737	$1,172	0.3%	$8.31	0.0%	COM NEW	185634201
ZURA	ZURA BIO LTD	50,000	$262	0.1%	$3.95	0.0%	CLASS A ORD SHS	G9TY5A101

Increased Positions (14)

KOD KODIAK SCIENCES INC 7.0%

Value ($000) $31,763 (+158.7%) Shares 1,136,000 (+51.5%) Est. Cost $10.75 Unrealized +90.6%

CELC CELCUITY INC 4.9%

Value ($000) $22,442 (+404.8%) Shares 225,000 (+150.0%) Est. Cost $65.33 Unrealized +25.8%

TNGX TANGO THERAPEUTICS INC 21.1%

Value ($000) $96,363 (+17.4%) Shares 10,876,219 (+11.3%) Est. Cost $5.05 Unrealized +70.7%

KYMR KYMERA THERAPEUTICS INC 5.6%

Value ($000) $25,607 (+41.8%) Shares 329,100 (+3.1%) Est. Cost $43.27 Unrealized +56.1%

PTGX PROTAGONIST THERAPEUTICS INC 3.2%

Value ($000) $14,848 (+103.2%) Shares 170,000 (+54.5%) Est. Cost $62.54 Unrealized +30.9%

— CIDARA THERAPEUTICS INC 2.6%

Value ($000) $11,707 (+154.7%) Shares 53,000 (+10.4%) Est. Cost $64.95 Unrealized —

ABVX ABIVAX SA 3.7%

Value ($000) $16,857 (+65.5%) Shares 125,000 (+4.2%) Est. Cost $86.90 Unrealized —

— MIND MEDICINE MINDMED INC 1.8%

Value ($000) $8,014 (+315.7%) Shares 598,500 (+266.1%) Est. Cost $12.95 Unrealized —

AVTX AVALO THERAPEUTICS INC 1.1%

Value ($000) $4,994 (+214.3%) Shares 275,000 (+120.0%) Est. Cost $13.12 Unrealized +28.7%

APGE APOGEE THERAPEUTICS INC 1.2%

Value ($000) $5,284 (+166.0%) Shares 70,000 (+40.0%) Est. Cost $45.27 Unrealized +39.1%

PGEN PRECIGEN INC 1.3%

Value ($000) $5,748 (+105.5%) Shares 1,375,000 (+61.8%) Est. Cost $3.22 Unrealized +20.1%

MLTX MOONLAKE IMMUNOTHERAPEUTICS 0.8%

Value ($000) $3,625 (+102.2%) Shares 275,000 (+10.0%) Est. Cost $48.45 Unrealized -75.7%

PEPG PEPGEN INC 0.5%

Value ($000) $2,434 (+110.7%) Shares 373,892 (+49.6%) Est. Cost $2.80 Unrealized +85.5%

INO INOVIO PHARMACEUTICALS INC 0.9%

Value ($000) $4,211 (-21.8%) Shares 2,420,122 (+5.2%) Est. Cost $1.93 Unrealized +14.2%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
KOD	KODIAK SCIENCES INC	1,136,000 (+51.5%)	$31,763 (+158.7%)	7.0%	$10.75	+90.6%	COM	50015M109
CELC	CELCUITY INC	225,000 (+150.0%)	$22,442 (+404.8%)	4.9%	$65.33	+25.8%	COM	15102K100
TNGX	TANGO THERAPEUTICS INC	10,876,219 (+11.3%)	$96,363 (+17.4%)	21.1%	$5.05	+70.7%	COM	87583X109
KYMR	KYMERA THERAPEUTICS INC	329,100 (+3.1%)	$25,607 (+41.8%)	5.6%	$43.27	+56.1%	COM	501575104
PTGX	PROTAGONIST THERAPEUTICS INC	170,000 (+54.5%)	$14,848 (+103.2%)	3.2%	$62.54	+30.9%	COM	74366E102
—	CIDARA THERAPEUTICS INC	53,000 (+10.4%)	$11,707 (+154.7%)	2.6%	$64.95	—	COM NEW	171757206
ABVX	ABIVAX SA	125,000 (+4.2%)	$16,857 (+65.5%)	3.7%	$86.90	—	SPONSORED ADS	00370M103
—	MIND MEDICINE MINDMED INC	598,500 (+266.1%)	$8,014 (+315.7%)	1.8%	$12.95	—	COM NEW	60255C885
AVTX	AVALO THERAPEUTICS INC	275,000 (+120.0%)	$4,994 (+214.3%)	1.1%	$13.12	+28.7%	COM NEW	05338F306
APGE	APOGEE THERAPEUTICS INC	70,000 (+40.0%)	$5,284 (+166.0%)	1.2%	$45.27	+39.1%	COM	03770N101
PGEN	PRECIGEN INC	1,375,000 (+61.8%)	$5,748 (+105.5%)	1.3%	$3.22	+20.1%	COM	74017N105
MLTX	MOONLAKE IMMUNOTHERAPEUTICS	275,000 (+10.0%)	$3,625 (+102.2%)	0.8%	$48.45	-75.7%	CLASS A ORD	61559X104
PEPG	PEPGEN INC	373,892 (+49.6%)	$2,434 (+110.7%)	0.5%	$2.80	+85.5%	COM	713317105
INO	INOVIO PHARMACEUTICALS INC	2,420,122 (+5.2%)	$4,211 (-21.8%)	0.9%	$1.93	+14.2%	COM SHS	45773H409

Exited Positions (4)

— MERUS N V 2.5%

Value ($000) $11,298 Shares 120,000 Est. Cost $42.05 Unrealized —

NKTR NEKTAR THERAPEUTICS 1.6%

Value ($000) $7,113 Shares 125,000 Est. Cost $11.24 Unrealized +398.1%

DNLI DENALI THERAPEUTICS INC 0.8%

Value ($000) $3,630 Shares 250,000 Est. Cost $14.37 Unrealized +17.5%

TIL INSTIL BIO INC 0.2%

Value ($000) $1,084 Shares 60,700 Est. Cost $30.49 Unrealized -51.5%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
—	MERUS N V	120,000	$11,298	2.5%	$42.05	—	—	N5749R100
NKTR	NEKTAR THERAPEUTICS	125,000	$7,113	1.6%	$11.24	+398.1%	—	640268306
DNLI	DENALI THERAPEUTICS INC	250,000	$3,630	0.8%	$14.37	+17.5%	—	24823R105
TIL	INSTIL BIO INC	60,700	$1,084	0.2%	$30.49	-51.5%	—	45783C200

Decreased Positions (8)

QURE UNIQURE NV 1.5%

Value ($000) $6,940 (-85.1%) Shares 290,000 (-63.7%) Est. Cost $9.43 Unrealized +309.1%

CYTK CYTOKINETICS INC 1.4%

Value ($000) $6,354 (-42.2%) Shares 100,000 (-50.0%) Est. Cost $41.20 Unrealized +51.0%

REPL REPLIMUNE GROUP INC 1.6%

Value ($000) $7,290 (+65.7%) Shares 750,000 (-28.6%) Est. Cost $11.51 Unrealized -26.1%

AMLX AMYLYX PHARMACEUTICALS INC 2.1%

Value ($000) $9,664 (-21.0%) Shares 800,000 (-11.1%) Est. Cost $4.71 Unrealized +188.7%

SLDB SOLID BIOSCIENCES INC 0.4%

Value ($000) $1,692 (-54.3%) Shares 300,000 (-50.0%) Est. Cost $5.85 Unrealized -7.3%

SRPT SAREPTA THERAPEUTICS INC 0.7%

Value ($000) $3,228 (-33.0%) Shares 150,000 (-40.0%) Est. Cost $20.31 Unrealized +3.8%

NRIX NURIX THERAPEUTICS INC 0.4%

Value ($000) $1,897 (+17.3%) Shares 100,000 (-42.9%) Est. Cost $22.92 Unrealized -37.3%

URGN UROGEN PHARMA LTD 2.6%

Value ($000) $11,710 (+2.1%) Shares 500,000 (-13.0%) Est. Cost $9.60 Unrealized +126.1%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
QURE	UNIQURE NV	290,000 (-63.7%)	$6,940 (-85.1%)	1.5%	$9.43	+309.1%	SHS	N90064101
CYTK	CYTOKINETICS INC	100,000 (-50.0%)	$6,354 (-42.2%)	1.4%	$41.20	+51.0%	COM NEW	23282W605
REPL	REPLIMUNE GROUP INC	750,000 (-28.6%)	$7,290 (+65.7%)	1.6%	$11.51	-26.1%	COM	76029N106
AMLX	AMYLYX PHARMACEUTICALS INC	800,000 (-11.1%)	$9,664 (-21.0%)	2.1%	$4.71	+188.7%	COM	03237H101
SLDB	SOLID BIOSCIENCES INC	300,000 (-50.0%)	$1,692 (-54.3%)	0.4%	$5.85	-7.3%	COM NEW	83422E204
SRPT	SAREPTA THERAPEUTICS INC	150,000 (-40.0%)	$3,228 (-33.0%)	0.7%	$20.31	+3.8%	COM	803607100
NRIX	NURIX THERAPEUTICS INC	100,000 (-42.9%)	$1,897 (+17.3%)	0.4%	$22.92	-37.3%	COM	67080M103
URGN	UROGEN PHARMA LTD	500,000 (-13.0%)	$11,710 (+2.1%)	2.6%	$9.60	+126.1%	COM	M96088105

Unchanged Positions (8)

RVMD REVOLUTION MEDICINES INC 7.0%

Value ($000) $31,860 Shares 400,000 Est. Cost $50.47 Unrealized +29.9%

PTCT PTC THERAPEUTICS INC 3.3%

Value ($000) $15,192 Shares 200,000 Est. Cost $52.09 Unrealized +39.5%

LBRX LB PHARMACEUTICALS INC 0.3%

Value ($000) $1,558 Shares 70,000 Est. Cost $15.87 Unrealized +10.1%

KALV KALVISTA PHARMACEUTICALS INC 0.1%

Value ($000) $329 Shares 20,400 Est. Cost $12.23 Unrealized +8.3%

— NUVATION BIO INC 0.0%

Value ($000) $88 Shares 266,666 Est. Cost $0.23 Unrealized —

CBIO CRESCENT BIOPHARMA INC. 1.2%

Value ($000) $5,381 Shares 453,686 Est. Cost $21.15 Unrealized -39.8%

MIST MILESTONE PHARMACEUTICALS IN 0.3%

Value ($000) $1,347 Shares 666,666 Est. Cost $1.76 Unrealized +22.5%

SRZNW SURROZEN INC 0.0%

Value ($000) $1 Shares 66,666 Est. Cost $0.02 Unrealized —

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
RVMD	REVOLUTION MEDICINES INC	400,000	$31,860	7.0%	$50.47	+29.9%	COM	76155X100
PTCT	PTC THERAPEUTICS INC	200,000	$15,192	3.3%	$52.09	+39.5%	COM	69366J200
LBRX	LB PHARMACEUTICALS INC	70,000	$1,558	0.3%	$15.87	+10.1%	COM SHS	50180M108
KALV	KALVISTA PHARMACEUTICALS INC	20,400	$329	0.1%	$12.23	+8.3%	COM	483497103
—	NUVATION BIO INC	266,666	$88	0.0%	$0.23	—	*W EXP 02/10/202	67080N119
CBIO	CRESCENT BIOPHARMA INC.	453,686	$5,381	1.2%	$21.15	-39.8%	COM	G2545C104
MIST	MILESTONE PHARMACEUTICALS IN	666,666	$1,347	0.3%	$1.76	+22.5%	COM	59935V107
SRZNW	SURROZEN INC	66,666	$1	0.0%	$0.02	—	*W EXP 08/01/203	86889P117