Ticker	Issuer	Shares	Value	%	Share Price	Est. Cost/Share	Unrealized @ Report Date	Class	CUSIP
IRON	DISC MEDICINE INC	8,000	$585K	0.4%	$73.14 *	$69.40	-5.7%	—	254604101
RAPP	RAPPORT THERAPEUTICS INC	14,000	$583K	0.4%	$41.67 *	$27.68	+21.4%	—	75383L102
RARE	ULTRAGENYX PHARMACEUTICAL IN	17,000	$568K	0.4%	$33.39 *	$22.52	-33.3%	—	90400D108
GLUE	MONTE ROSA THERAPEUTICS INC	23,000	$557K	0.4%	$24.20 *	$19.12	-37.6%	—	61225M102
IONS	IONIS PHARMACEUTICALS INC	6,800	$539K	0.4%	$79.29 *	$75.30	-40.7%	—	462222100
PHVS	PHARVARIS N V	15,000	$519K	0.4%	$34.58 *	$24.09	+31.7%	—	N69605108
ACAD	ACADIA PHARMACEUTICALS INC	19,766	$500K	0.3%	$25.30 *	$23.90	-15.7%	—	004225108
PTCT	PTC THERAPEUTICS INC	6,000	$489K	0.3%	$81.57 *	$72.67	-10.9%	—	69366J200
CLDX	CELLDEX THERAPEUTICS INC NEW	13,000	$484K	0.3%	$37.21 *	$26.34	+23.1%	—	15117B202
COGT	COGENT BIOSCIENCES INC	12,000	$464K	0.3%	$38.70 *	$28.11	+13.9%	—	19240Q201
ALNY	ALNYLAM PHARMACEUTICALS INC	1,465	$441K	0.3%	$301.03 *	$432.30	-42.9%	—	02043Q107
CRNX	CRINETICS PHARMACEUTICALS IN	11,000	$412K	0.3%	$37.42 *	$44.52	+90.8%	—	22663K107
NAMS	NEWAMSTERDAM PHARMA COMPANY	12,000	$407K	0.3%	$33.89 *	$36.39	-33.2%	—	N62509109
LQDA	LIQUIDIA CORPORATION	5,000	$399K	0.3%	$79.73 *	$53.60	-43.5%	—	53635D202
VKTX	VIKING THERAPEUTICS INC	10,000	$390K	0.3%	$39.01 *	$35.37	-7.8%	—	92686J106
ELVN	ENLIVEN THERAPEUTICS INC	7,000	$355K	0.2%	$50.75 *	$27.70	+65.5%	—	29337E102
SYRE	SPYRE THERAPEUTICS INC	4,000	$355K	0.2%	$88.78	$26.13	+240.7%	—	00773J202
VERA	VERA THERAPEUTICS INC	7,000	$300K	0.2%	$42.91 *	$35.52	-9.1%	—	92337R101
CRSP	CRISPR THERAPEUTICS AG	5,000	$273K	0.2%	$54.54	$59.89	-7.6%	—	H17182108
ZYME	ZYMEWORKS INC	10,000	$261K	0.2%	$26.14	$21.81	+21.4%	—	98985Y108
XENE	XENON PHARMACEUTICALS INC	4,200	$254K	0.2%	$60.36 *	$42.00	-11.4%	—	98420N105
AXSM	AXSOME THERAPEUTICS INC.	1,000	$245K	0.2%	$244.77 *	$172.73	+6.8%	—	05464T104
AVBP	ARRIVENT BIOPHARMA INC	7,041	$245K	0.2%	$34.74 *	$29.51	+2.6%	—	04272N102
JAZZ	JAZZ PHARMACEUTICALS PLC	971	$234K	0.2%	$240.97 *	$219.08	+5.7%	—	G50871105
KOD	KODIAK SCIENCES INC	6,000	$234K	0.2%	$38.96 *	$20.48	+362.9%	—	50015M109
BBIO	BRIDGEBIO PHARMA INC	3,000	$223K	0.2%	$74.48 *	$65.64	+0.2%	—	10806X102
RYTM	RHYTHM PHARMACEUTICALS INC	2,000	$222K	0.2%	$111.03 *	$90.41	+5.3%	—	76243J105
DNLI	DENALI THERAPEUTICS INC	8,463	$218K	0.1%	$25.72 *	$20.55	+0.6%	—	24823R105
ARWR	ARROWHEAD PHARMACEUTICALS IN	2,600	$212K	0.1%	$81.51 *	$73.86	-11.4%	—	04280A100
SRRK	SCHOLAR ROCK HLDG CORP	3,827	$210K	0.1%	$55.00 *	$48.31	+0.0%	—	80706P103
AMLX	AMYLYX PHARMACEUTICALS INC	10,838	$195K	0.1%	$17.96 *	$13.58	+114.2%	—	03237H101
EYPT	EYEPOINT INC	10,000	$143K	0.1%	$14.30 *	$14.17	-76.9%	—	30233G209

Decreased Positions (27)

XBI SPDR SERIES TRUST 41.8%

Value $60.94M (-32.4%) Shares 386,500 (-32.2%) Share Price $157.68 Est. Cost/Share $130.01 Unrealized @ Report Date +21.3%

INCY INCYTE CORP 0.2%

Value $243K (-59.6%) Shares 2,000 (-62.3%) Share Price $121.35 Est. Cost/Share $96.76 Unrealized @ Report Date +25.4%

TRVI TREVI THERAPEUTICS INC 0.1%

Value $215K (-61.6%) Shares 15,000 (-50.0%) Share Price $14.32 Est. Cost/Share $11.19 Unrealized @ Report Date +27.9%

RPRX ROYALTY PHARMA PLC 0.2%

Value $292K (-52.7%) Shares 5,000 (-54.5%) Share Price $58.36 Est. Cost/Share $38.13 Unrealized @ Report Date +53.0%

NRIX NURIX THERAPEUTICS INC 0.2%

Value $285K (-53.1%) Shares 12,000 (-52.0%) Share Price $23.71 Est. Cost/Share $14.37 Unrealized @ Report Date +65.0%

ARGX ARGENX SE 0.2%

Value $288K (-51.6%) Shares 300 (-53.2%) Share Price $958.91 Est. Cost/Share $854.69 Unrealized @ Report Date +12.2%

DYN DYNE THERAPEUTICS INC 0.1%

Value $161K (-63.7%) Shares 10,000 (-50.0%) Share Price $16.11 Est. Cost/Share $18.94 Unrealized @ Report Date -14.9%

TGTX TG THERAPEUTICS INC 0.2%

Value $279K (-49.2%) Shares 5,000 (-50.0%) Share Price $55.78 Est. Cost/Share $32.66 Unrealized @ Report Date +70.8%

IMCR IMMUNOCORE HLDGS PLC 0.1%

Value $212K (-55.9%) Shares 7,000 (-53.8%) Share Price $30.29 Est. Cost/Share $35.16 Unrealized @ Report Date -13.9%

AUPH AURINIA PHARMACEUTICALS INC 0.2%

Value $243K (-52.3%) Shares 15,000 (-50.0%) Share Price $16.20 Est. Cost/Share $14.18 Unrealized @ Report Date +14.2%

IMVT IMMUNOVANT INC 0.2%

Value $236K (-52.8%) Shares 7,000 (-46.2%) Share Price $33.78 Est. Cost/Share $22.30 Unrealized @ Report Date +51.5%

ARQT ARCUTIS BIOTHERAPEUTICS INC 0.2%

Value $264K (-48.8%) Shares 10,000 (-49.2%) Share Price $26.43 Est. Cost/Share $25.60 Unrealized @ Report Date +3.3%

NBIX NEUROCRINE BIOSCIENCES INC 0.2%

Value $255K (-49.5%) Shares 1,800 (-40.0%) Share Price $141.84 Est. Cost/Share $144.51 Unrealized @ Report Date -1.8%

KYMR KYMERA THERAPEUTICS INC 0.2%

Value $224K (-51.3%) Shares 2,000 (-50.0%) Share Price $111.79 Est. Cost/Share $67.53 Unrealized @ Report Date +65.5%

DFTX DEFINIUM THERAPEUTICS INC 0.2%

Value $247K (-47.4%) Shares 6,500 (-35.0%) Share Price $38.06 Est. Cost/Share $16.97 Unrealized @ Report Date +124.3%

HALO HALOZYME THERAPEUTICS INC 0.2%

Value $331K (-39.5%) Shares 3,000 (-57.1%) Share Price $110.40 Est. Cost/Share $67.27 Unrealized @ Report Date +64.1%

SNDX SYNDAX PHARMACEUTICALS INC 0.2%

Value $226K (-48.4%) Shares 12,000 (-40.0%) Share Price $18.80 Est. Cost/Share $17.45 Unrealized @ Report Date +7.8%

ARDX ARDELYX INC 0.1%

Value $103K (-66.5%) Shares 30,000 (-50.0%) Share Price $3.42 Est. Cost/Share $6.62 Unrealized @ Report Date -48.3%

ASND ASCENDIS PHARMA A/S 0.2%

Value $228K (-43.1%) Shares 1,000 (-33.3%) Share Price $227.83 * Est. Cost/Share $233.60 Unrealized @ Report Date +12.8%

TARS TARSUS PHARMACEUTICALS INC 0.2%

Value $275K (-37.6%) Shares 3,500 (-50.0%) Share Price $78.61 Est. Cost/Share $74.33 Unrealized @ Report Date +5.8%

STOK STOKE THERAPEUTICS INC 0.2%

Value $234K (-40.4%) Shares 9,000 (-25.0%) Share Price $26.00 Est. Cost/Share $30.06 Unrealized @ Report Date -13.5%

PTGX PROTAGONIST THERAPEUTICS INC 0.1%

Value $211K (-42.5%) Shares 1,500 (-50.0%) Share Price $140.89 Est. Cost/Share $81.85 Unrealized @ Report Date +72.1%

EXEL EXELIXIS INC 0.2%

Value $292K (-32.9%) Shares 5,000 (-37.5%) Share Price $58.41 Est. Cost/Share $41.37 Unrealized @ Report Date +41.2%

CMPS COMPASS PATHWAYS PLC 0.1%

Value $124K (-51.2%) Shares 10,000 (-44.4%) Share Price $12.44 Est. Cost/Share $6.73 Unrealized @ Report Date +85.0%

IMNM IMMUNOME INC 0.2%

Value $258K (-32.3%) Shares 12,000 (-33.3%) Share Price $21.51 Est. Cost/Share $17.55 Unrealized @ Report Date +22.6%

HRMY HARMONY BIOSCIENCES HLDGS IN 0.2%

Value $275K (-24.5%) Shares 7,000 (-30.0%) Share Price $39.26 Est. Cost/Share $32.88 Unrealized @ Report Date +19.4%

KNSA KINIKSA PHARMACEUTICALS INTL 0.2%

Value $261K (-18.3%) Shares 3,500 (-30.0%) Share Price $74.61 Est. Cost/Share $40.11 Unrealized @ Report Date +86.0%

Ticker	Issuer	Shares	Value	%	Share Price	Est. Cost/Share	Unrealized @ Report Date	Class	CUSIP
XBI	SPDR SERIES TRUST	386,500 (-32.2%)	$60.94M (-32.4%)	41.8%	$157.68	$130.01	+21.3%	ST STR SP BIOT	78464A870
INCY	INCYTE CORP	2,000 (-62.3%)	$243K (-59.6%)	0.2%	$121.35	$96.76	+25.4%	COM	45337C102
TRVI	TREVI THERAPEUTICS INC	15,000 (-50.0%)	$215K (-61.6%)	0.1%	$14.32	$11.19	+27.9%	COM	89532M101
RPRX	ROYALTY PHARMA PLC	5,000 (-54.5%)	$292K (-52.7%)	0.2%	$58.36	$38.13	+53.0%	SHS CLASS A	G7709Q104
NRIX	NURIX THERAPEUTICS INC	12,000 (-52.0%)	$285K (-53.1%)	0.2%	$23.71	$14.37	+65.0%	COM	67080M103
ARGX	ARGENX SE	300 (-53.2%)	$288K (-51.6%)	0.2%	$958.91	$854.69	+12.2%	SPONSORED ADR	04016X101
DYN	DYNE THERAPEUTICS INC	10,000 (-50.0%)	$161K (-63.7%)	0.1%	$16.11	$18.94	-14.9%	COM	26818M108
TGTX	TG THERAPEUTICS INC	5,000 (-50.0%)	$279K (-49.2%)	0.2%	$55.78	$32.66	+70.8%	COM	88322Q108
IMCR	IMMUNOCORE HLDGS PLC	7,000 (-53.8%)	$212K (-55.9%)	0.1%	$30.29	$35.16	-13.9%	ADS	45258D105
AUPH	AURINIA PHARMACEUTICALS INC	15,000 (-50.0%)	$243K (-52.3%)	0.2%	$16.20	$14.18	+14.2%	COM	05156V102
IMVT	IMMUNOVANT INC	7,000 (-46.2%)	$236K (-52.8%)	0.2%	$33.78	$22.30	+51.5%	COM	45258J102
ARQT	ARCUTIS BIOTHERAPEUTICS INC	10,000 (-49.2%)	$264K (-48.8%)	0.2%	$26.43	$25.60	+3.3%	COM	03969K108
NBIX	NEUROCRINE BIOSCIENCES INC	1,800 (-40.0%)	$255K (-49.5%)	0.2%	$141.84	$144.51	-1.8%	COM	64125C109
KYMR	KYMERA THERAPEUTICS INC	2,000 (-50.0%)	$224K (-51.3%)	0.2%	$111.79	$67.53	+65.5%	COM	501575104
DFTX	DEFINIUM THERAPEUTICS INC	6,500 (-35.0%)	$247K (-47.4%)	0.2%	$38.06	$16.97	+124.3%	COM SHS	24477V105
HALO	HALOZYME THERAPEUTICS INC	3,000 (-57.1%)	$331K (-39.5%)	0.2%	$110.40	$67.27	+64.1%	COM	40637H109
SNDX	SYNDAX PHARMACEUTICALS INC	12,000 (-40.0%)	$226K (-48.4%)	0.2%	$18.80	$17.45	+7.8%	COM	87164F105
ARDX	ARDELYX INC	30,000 (-50.0%)	$103K (-66.5%)	0.1%	$3.42	$6.62	-48.3%	COM	039697107
ASND	ASCENDIS PHARMA A/S	1,000 (-33.3%)	$228K (-43.1%)	0.2%	$227.83 *	$233.60	+12.8%	ORD SHS	K08588103
TARS	TARSUS PHARMACEUTICALS INC	3,500 (-50.0%)	$275K (-37.6%)	0.2%	$78.61	$74.33	+5.8%	COM	87650L103
STOK	STOKE THERAPEUTICS INC	9,000 (-25.0%)	$234K (-40.4%)	0.2%	$26.00	$30.06	-13.5%	COM	86150R107
PTGX	PROTAGONIST THERAPEUTICS INC	1,500 (-50.0%)	$211K (-42.5%)	0.1%	$140.89	$81.85	+72.1%	COM	74366E102
EXEL	EXELIXIS INC	5,000 (-37.5%)	$292K (-32.9%)	0.2%	$58.41	$41.37	+41.2%	COM	30161Q104
CMPS	COMPASS PATHWAYS PLC	10,000 (-44.4%)	$124K (-51.2%)	0.1%	$12.44	$6.73	+85.0%	SPONSORED ADS	20451W101
IMNM	IMMUNOME INC	12,000 (-33.3%)	$258K (-32.3%)	0.2%	$21.51	$17.55	+22.6%	COM	45257U108
HRMY	HARMONY BIOSCIENCES HLDGS IN	7,000 (-30.0%)	$275K (-24.5%)	0.2%	$39.26	$32.88	+19.4%	COM	413197104
KNSA	KINIKSA PHARMACEUTICALS INTL	3,500 (-30.0%)	$261K (-18.3%)	0.2%	$74.61	$40.11	+86.0%	ORD SHS CL A	G52694109

Unchanged Positions (16)

NTLA INTELLIA THERAPEUTICS INC 0.2%

Value $241K Shares 20,000 Share Price $12.06 Est. Cost/Share $12.72 Unrealized @ Report Date -5.2%

MIRM MIRUM PHARMACEUTICALS INC 0.1%

Value $214K Shares 2,500 Share Price $85.48 Est. Cost/Share $71.78 Unrealized @ Report Date +19.1%

ALKS ALKERMES PLC 0.2%

Value $243K Shares 6,000 Share Price $40.52 Est. Cost/Share $29.95 Unrealized @ Report Date +35.3%

TNGX TANGO THERAPEUTICS INC 0.2%

Value $250K Shares 10,000 Share Price $24.95 Est. Cost/Share $13.93 Unrealized @ Report Date +79.1%

CTMX CYTOMX THERAPEUTICS INC. 0.1%

Value $107K Shares 39,400 Share Price $2.72 Est. Cost/Share $3.82 Unrealized @ Report Date -28.8%

OLMA OLEMA PHARMACEUTICALS INC 0.1%

Value $86,400 Shares 10,000 Share Price $8.64 Est. Cost/Share $17.79 Unrealized @ Report Date -51.4%

ORKA ORUKA THERAPEUTICS INC 0.2%

Value $250K Shares 3,000 Share Price $83.29 Est. Cost/Share $34.76 Unrealized @ Report Date +139.6%

ORIC ORIC PHARMACEUTICALS INC 0.1%

Value $175K Shares 13,000 Share Price $13.47 Est. Cost/Share $11.35 Unrealized @ Report Date +18.7%

OCUL OCULAR THERAPEUTIX INC 0.1%

Value $115K Shares 15,000 Share Price $7.67 Est. Cost/Share $12.15 Unrealized @ Report Date -36.9%

KRYS KRYSTAL BIOTECH INC 0.2%

Value $230K Shares 692 Share Price $332.56 Est. Cost/Share $298.78 Unrealized @ Report Date +11.3%

DNTH DIANTHUS THERAPEUTICS INC 0.2%

Value $220K Shares 2,500 Share Price $88.05 Est. Cost/Share $38.77 Unrealized @ Report Date +127.1%

RVMD REVOLUTION MEDICINES INC 0.2%

Value $246K Shares 1,200 Share Price $205.26 Est. Cost/Share $146.07 Unrealized @ Report Date +40.5%

SUPN SUPERNUS PHARMACEUTICALS 0.2%

Value $258K Shares 6,000 Share Price $43.04 Est. Cost/Share $48.62 Unrealized @ Report Date -11.5%

MDGL MADRIGAL PHARMACEUTICALS INC 0.2%

Value $302K Shares 600 Share Price $503.96 Est. Cost/Share $510.76 Unrealized @ Report Date -1.3%

SGOV ISHARES TR 48.3%

Value $70.48M Shares 700,000 Share Price $100.68 Est. Cost/Share $100.50 Unrealized @ Report Date +0.2%

EWTX EDGEWISE THERAPEUTICS INC 0.1%

Value $203K Shares 5,000 Share Price $40.60 Est. Cost/Share $28.84 Unrealized @ Report Date +40.8%

Ticker	Issuer	Shares	Value	%	Share Price	Est. Cost/Share	Unrealized @ Report Date	Class	CUSIP
NTLA	INTELLIA THERAPEUTICS INC	20,000	$241K	0.2%	$12.06	$12.72	-5.2%	COM	45826J105
MIRM	MIRUM PHARMACEUTICALS INC	2,500	$214K	0.1%	$85.48	$71.78	+19.1%	COM	604749101
ALKS	ALKERMES PLC	6,000	$243K	0.2%	$40.52	$29.95	+35.3%	SHS	G01767105
TNGX	TANGO THERAPEUTICS INC	10,000	$250K	0.2%	$24.95	$13.93	+79.1%	COM	87583X109
CTMX	CYTOMX THERAPEUTICS INC.	39,400	$107K	0.1%	$2.72	$3.82	-28.8%	COM	23284F105
OLMA	OLEMA PHARMACEUTICALS INC	10,000	$86,400	0.1%	$8.64	$17.79	-51.4%	COM	68062P106
ORKA	ORUKA THERAPEUTICS INC	3,000	$250K	0.2%	$83.29	$34.76	+139.6%	COM	687604108
ORIC	ORIC PHARMACEUTICALS INC	13,000	$175K	0.1%	$13.47	$11.35	+18.7%	COM	68622P109
OCUL	OCULAR THERAPEUTIX INC	15,000	$115K	0.1%	$7.67	$12.15	-36.9%	COM	67576A100
KRYS	KRYSTAL BIOTECH INC	692	$230K	0.2%	$332.56	$298.78	+11.3%	COM	501147102
DNTH	DIANTHUS THERAPEUTICS INC	2,500	$220K	0.2%	$88.05	$38.77	+127.1%	COM	252828108
RVMD	REVOLUTION MEDICINES INC	1,200	$246K	0.2%	$205.26	$146.07	+40.5%	COM	76155X100
SUPN	SUPERNUS PHARMACEUTICALS	6,000	$258K	0.2%	$43.04	$48.62	-11.5%	COM	868459108
MDGL	MADRIGAL PHARMACEUTICALS INC	600	$302K	0.2%	$503.96	$510.76	-1.3%	COM	558868105
SGOV	ISHARES TR	700,000	$70.48M	48.3%	$100.68	$100.50	+0.2%	0-3 MTH TREASURY	46436E718
EWTX	EDGEWISE THERAPEUTICS INC	5,000	$203K	0.1%	$40.60	$28.84	+40.8%	COM	28036F105