ACADIA PHARMACEUTICALS INC

Ticker: ACAD CUSIP: 004225108 Class: Common Stock

MANUFACTURERS LIFE INSURANCE COMPANY, THE's Holding History (CIK: 0000928047)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 532,533 Value ($000) $14,224 Avg Close $23.90 Range $19.69 - $28.35

Q3 2025

Shares 534,111 Value ($000) $11,398 Avg Close $23.65 Range $20.02 - $26.65

Q2 2025

Shares 787,524 Value ($000) $16,987 Avg Close $18.59 Range $13.40 - $25.23

Q1 2025

Shares 804,119 Value ($000) $13,356 Avg Close $18.17 Range $16.28 - $20.68

Q4 2024

Shares 628,016 Value ($000) $11,524 Avg Close $16.14 Range $14.15 - $19.05

Q3 2024

Shares 413,269 Value ($000) $6,356 Avg Close $16.68 Range $15.08 - $19.44

Q2 2024

Shares 462,078 Value ($000) $7,509 Avg Close $16.14 Range $14.55 - $18.63

Q1 2024

Shares 1,171,624 Value ($000) $21,663 Avg Close $24.78 Range $17.56 - $31.82

Q4 2023

Shares 846,028 Value ($000) $26,489 Avg Close $23.88 Range $20.31 - $32.59

Q3 2023

Shares 1,050,394 Value ($000) $21,890 Avg Close $27.16 Range $20.54 - $33.99

Q2 2023

Shares 913,025 Value ($000) $21,867 Avg Close $22.23 Range $17.71 - $26.04

Q1 2023

Shares 872,050 Value ($000) $16,412 Avg Close $19.05 Range $15.77 - $21.87

Q4 2022

Shares 929,277 Value ($000) $14,797 Avg Close $15.63 Range $13.73 - $18.78

Q3 2022

Shares 916,398 Value ($000) $14,971 Avg Close $16.19 Range $13.80 - $18.31

Q2 2022

Shares 905,013 Value ($000) $12,763 Avg Close $18.68 Range $12.24 - $28.06

Q1 2022

Shares 875,122 Value ($000) $21,207 Avg Close $24.20 Range $20.74 - $27.81

Q4 2021

Shares 793,900 Value ($000) $18,530 Avg Close $20.11 Range $16.55 - $27.19

Q3 2021

Shares 1,020,260 Value ($000) $16,947 Avg Close $19.28 Range $15.68 - $24.77

Q2 2021

Shares 989,813 Value ($000) $24,141 Avg Close $22.57 Range $19.20 - $27.68

Q1 2021

Shares 609,810 Value ($000) $15,733 Avg Close $44.02 Range $23.35 - $55.85

Q4 2020

Shares 282,915 Value ($000) $15,125 Avg Close $49.64 Range $40.38 - $57.46

Q1 2020

Shares 72,006 Value ($000) $3,042 Avg Close $41.20 Range $30.02 - $47.99

Q4 2019

Shares 63,932 Value ($000) $2,735 Avg Close $43.50 Range $35.35 - $53.70

Q3 2019

Shares 65,945 Value ($000) $2,425 Avg Close $30.32 Range $21.56 - $44.85

Q2 2019

Shares 66,024 Value ($000) $1,765 Avg Close $25.54 Range $22.45 - $28.67

Q1 2019

Shares 74,138 Value ($000) $1,990 Avg Close $23.35 Range $15.73 - $28.12

Q4 2018

Shares 61,056 Value ($000) $987 Avg Close $19.42 Range $14.01 - $23.55

Q3 2018

Shares 28,774 Value ($000) $597 Avg Close $15.73 Range $12.77 - $22.22

Q2 2018

Shares 74,814 Value ($000) $1,143 Avg Close $17.83 Range $14.51 - $22.56

Q1 2018

Shares 136,980 Value ($000) $3,078 Avg Close $27.69 Range $21.81 - $32.99

Q4 2017

Shares 4,034 Value ($000) $121 Avg Close $31.98 Range $26.01 - $41.20

Q3 2017

Shares 4,380 Value ($000) $165 Avg Close $32.53 Range $26.41 - $38.54

Q2 2017

Shares 4,380 Value ($000) $44 Avg Close $29.80 Range $25.06 - $36.20

Q1 2017

Shares 3,863 Value ($000) $133 Avg Close $35.30 Range $28.53 - $40.83

Q4 2016

Shares 3,485 Value ($000) $100 Avg Close $26.46 Range $20.68 - $31.70

Q3 2016

Shares 3,485 Value ($000) $111 Avg Close $33.90 Range $30.50 - $38.08

Q2 2016

Shares 3,092 Value ($000) $100 Avg Close $33.47 Range $26.50 - $42.49

Q1 2016

Shares 84,083 Value ($000) $2,187 Avg Close $21.84 Range $16.64 - $35.20

Q4 2015

Shares 89,126 Value ($000) $3,177 Avg Close $35.23 Range $30.51 - $43.30

Q3 2015

Shares 93,511 Value ($000) $3,092 Avg Close $41.61 Range $30.03 - $51.99

Q2 2015

Shares 179,035 Value ($000) $7,498 Avg Close $38.70 Range $31.00 - $43.24

Q1 2015

Shares 52,205 Value ($000) $1,702 Avg Close $34.37 Range $29.45 - $46.48

Q4 2014

Shares 50,510 Value ($000) $1,604 Avg Close $28.36 Range $22.04 - $33.49

Q3 2014

Shares 51,616 Value ($000) $1,278 Avg Close $23.39 Range $19.21 - $29.31

Q2 2014

Shares 50,664 Value ($000) $1,145 Avg Close $20.88 Range $15.64 - $25.50

Q1 2014

Shares 53,440 Value ($000) $1,300 Avg Close $25.30 Range $21.20 - $32.00

Q4 2013

Shares 53,687 Value ($000) $1,342 Avg Close $23.59 Range $19.65 - $29.73

Q3 2013

Shares 54,622 Value ($000) $1,501 Avg Close $20.91 Range $17.02 - $28.38

Q2 2013

Shares 54,924 Value ($000) $997 Avg Close $13.77 Range $7.40 - $20.09

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	532,533	$14,224	$23.90	$19.69 - $28.35
Q3 2025	534,111	$11,398	$23.65	$20.02 - $26.65
Q2 2025	787,524	$16,987	$18.59	$13.40 - $25.23
Q1 2025	804,119	$13,356	$18.17	$16.28 - $20.68
Q4 2024	628,016	$11,524	$16.14	$14.15 - $19.05
Q3 2024	413,269	$6,356	$16.68	$15.08 - $19.44
Q2 2024	462,078	$7,509	$16.14	$14.55 - $18.63
Q1 2024	1,171,624	$21,663	$24.78	$17.56 - $31.82
Q4 2023	846,028	$26,489	$23.88	$20.31 - $32.59
Q3 2023	1,050,394	$21,890	$27.16	$20.54 - $33.99
Q2 2023	913,025	$21,867	$22.23	$17.71 - $26.04
Q1 2023	872,050	$16,412	$19.05	$15.77 - $21.87
Q4 2022	929,277	$14,797	$15.63	$13.73 - $18.78
Q3 2022	916,398	$14,971	$16.19	$13.80 - $18.31
Q2 2022	905,013	$12,763	$18.68	$12.24 - $28.06
Q1 2022	875,122	$21,207	$24.20	$20.74 - $27.81
Q4 2021	793,900	$18,530	$20.11	$16.55 - $27.19
Q3 2021	1,020,260	$16,947	$19.28	$15.68 - $24.77
Q2 2021	989,813	$24,141	$22.57	$19.20 - $27.68
Q1 2021	609,810	$15,733	$44.02	$23.35 - $55.85
Q4 2020	282,915	$15,125	$49.64	$40.38 - $57.46
Q1 2020	72,006	$3,042	$41.20	$30.02 - $47.99
Q4 2019	63,932	$2,735	$43.50	$35.35 - $53.70
Q3 2019	65,945	$2,425	$30.32	$21.56 - $44.85
Q2 2019	66,024	$1,765	$25.54	$22.45 - $28.67
Q1 2019	74,138	$1,990	$23.35	$15.73 - $28.12
Q4 2018	61,056	$987	$19.42	$14.01 - $23.55
Q3 2018	28,774	$597	$15.73	$12.77 - $22.22
Q2 2018	74,814	$1,143	$17.83	$14.51 - $22.56
Q1 2018	136,980	$3,078	$27.69	$21.81 - $32.99
Q4 2017	4,034	$121	$31.98	$26.01 - $41.20
Q3 2017	4,380	$165	$32.53	$26.41 - $38.54
Q2 2017	4,380	$44	$29.80	$25.06 - $36.20
Q1 2017	3,863	$133	$35.30	$28.53 - $40.83
Q4 2016	3,485	$100	$26.46	$20.68 - $31.70
Q3 2016	3,485	$111	$33.90	$30.50 - $38.08
Q2 2016	3,092	$100	$33.47	$26.50 - $42.49
Q1 2016	84,083	$2,187	$21.84	$16.64 - $35.20
Q4 2015	89,126	$3,177	$35.23	$30.51 - $43.30
Q3 2015	93,511	$3,092	$41.61	$30.03 - $51.99
Q2 2015	179,035	$7,498	$38.70	$31.00 - $43.24
Q1 2015	52,205	$1,702	$34.37	$29.45 - $46.48
Q4 2014	50,510	$1,604	$28.36	$22.04 - $33.49
Q3 2014	51,616	$1,278	$23.39	$19.21 - $29.31
Q2 2014	50,664	$1,145	$20.88	$15.64 - $25.50
Q1 2014	53,440	$1,300	$25.30	$21.20 - $32.00
Q4 2013	53,687	$1,342	$23.59	$19.65 - $29.73
Q3 2013	54,622	$1,501	$20.91	$17.02 - $28.38
Q2 2013	54,924	$997	$13.77	$7.40 - $20.09