ACADIA PHARMACEUTICALS INC

Ticker: ACAD CUSIP: 004225108 Class: Common Stock

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 1,119,117 Value ($000) $29,892 Avg Close $23.90 Range $19.69 - $28.35

Q3 2025

Shares 665,891 Value ($000) $14,210 Avg Close $23.65 Range $20.02 - $26.65

Q2 2025

Shares 483,098 Value ($000) $10,420 Avg Close $18.59 Range $13.40 - $25.23

Q1 2025

Shares 816,656 Value ($000) $13,565 Avg Close $18.17 Range $16.28 - $20.68

Q4 2024

Shares 1,243,442 Value ($000) $22,817 Avg Close $16.14 Range $14.15 - $19.05

Q3 2024

Shares 1,110,256 Value ($000) $17,076 Avg Close $16.68 Range $15.08 - $19.44

Q2 2024

Shares 347,717 Value ($000) $5,650 Avg Close $16.14 Range $14.55 - $18.63

Q1 2024

Shares 109,429 Value ($000) $2,023 Avg Close $24.78 Range $17.56 - $31.82

Q4 2023

Shares 348,728 Value ($000) $10,919 Avg Close $23.88 Range $20.31 - $32.59

Q3 2023

Shares 70,100 Value ($000) $1,461 Avg Close $27.16 Range $20.54 - $33.99

Q2 2023

Shares 366,788 Value ($000) $8,785 Avg Close $22.23 Range $17.71 - $26.04

Q1 2023

Shares 106,200 Value ($000) $1,999 Avg Close $19.05 Range $15.77 - $21.87

Q4 2022

Shares 11,137 Value ($000) $177 Avg Close $15.63 Range $13.73 - $18.78

Q2 2022

Shares 58,800 Value ($000) $828 Avg Close $18.68 Range $12.24 - $28.06

Q1 2022

Shares 240,471 Value ($000) $5,824 Avg Close $24.20 Range $20.74 - $27.81

Q4 2021

Shares 26,100 Value ($000) $609 Avg Close $20.11 Range $16.55 - $27.19

Q3 2021

Shares 15,700 Value ($000) $261 Avg Close $19.28 Range $15.68 - $24.77

Q2 2021

Shares 13,800 Value ($000) $337 Avg Close $22.57 Range $19.20 - $27.68

Q2 2020

Shares 286,618 Value ($000) $13,892 Avg Close $48.00 Range $38.45 - $53.75

Q4 2019

Shares 71,480 Value ($000) $3,058 Avg Close $43.50 Range $35.35 - $53.70

Q3 2019

Shares 209,496 Value ($000) $7,540 Avg Close $30.32 Range $21.56 - $44.85

Q2 2019

Shares 198,623 Value ($000) $5,309 Avg Close $25.54 Range $22.45 - $28.67

Q4 2016

Shares 49,639 Value ($000) $1,432 Avg Close $26.46 Range $20.68 - $31.70

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	1,119,117	$29,892	$23.90	$19.69 - $28.35
Q3 2025	665,891	$14,210	$23.65	$20.02 - $26.65
Q2 2025	483,098	$10,420	$18.59	$13.40 - $25.23
Q1 2025	816,656	$13,565	$18.17	$16.28 - $20.68
Q4 2024	1,243,442	$22,817	$16.14	$14.15 - $19.05
Q3 2024	1,110,256	$17,076	$16.68	$15.08 - $19.44
Q2 2024	347,717	$5,650	$16.14	$14.55 - $18.63
Q1 2024	109,429	$2,023	$24.78	$17.56 - $31.82
Q4 2023	348,728	$10,919	$23.88	$20.31 - $32.59
Q3 2023	70,100	$1,461	$27.16	$20.54 - $33.99
Q2 2023	366,788	$8,785	$22.23	$17.71 - $26.04
Q1 2023	106,200	$1,999	$19.05	$15.77 - $21.87
Q4 2022	11,137	$177	$15.63	$13.73 - $18.78
Q2 2022	58,800	$828	$18.68	$12.24 - $28.06
Q1 2022	240,471	$5,824	$24.20	$20.74 - $27.81
Q4 2021	26,100	$609	$20.11	$16.55 - $27.19
Q3 2021	15,700	$261	$19.28	$15.68 - $24.77
Q2 2021	13,800	$337	$22.57	$19.20 - $27.68
Q2 2020	286,618	$13,892	$48.00	$38.45 - $53.75
Q4 2019	71,480	$3,058	$43.50	$35.35 - $53.70
Q3 2019	209,496	$7,540	$30.32	$21.56 - $44.85
Q2 2019	198,623	$5,309	$25.54	$22.45 - $28.67
Q4 2016	49,639	$1,432	$26.46	$20.68 - $31.70