ACHAOGEN INC

CUSIP: 004449104 Class: COM

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2018
Shares 94,807 Value ($000) $117 Avg Close — Range —
Q3 2018
Shares 124,908 Value ($000) $498 Avg Close — Range —
Q4 2017
Shares 24,243 Value ($000) $260 Avg Close — Range —