ACELRX PHARMACEUTICALS INC

CUSIP: 00444T100 Class: COM

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q3 2022
Shares 65,333 Value ($000) $14 Avg Close — Range —
Q1 2021
Shares 46,180 Value ($000) $79 Avg Close — Range —
Q2 2020
Shares 106,580 Value ($000) $129 Avg Close — Range —
Q4 2019
Shares 25,280 Value ($000) $53 Avg Close — Range —
Q1 2019
Shares 71,144 Value ($000) $248 Avg Close — Range —
Q4 2018
Shares 559,408 Value ($000) $1,292 Avg Close — Range —
Q3 2018
Shares 60,744 Value ($000) $234 Avg Close — Range —
Q1 2016
Shares 10,934 Value ($000) $34 Avg Close — Range —
Q4 2015
Shares 42,531 Value ($000) $164 Avg Close — Range —
Q1 2014
Shares 49,976 Value ($000) $600 Avg Close — Range —