ACHIEVE LIFE SCIENCES INC

Ticker: ACHV CUSIP: 004468500 Class: COM

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 748,616 Value ($000) $3,721 Avg Close $4.36 Range $3.03 - $5.78

Q3 2025

Shares 439,064 Value ($000) $1,383 Avg Close $2.74 Range $2.02 - $3.49

Q3 2021

Shares 18,532 Value ($000) $158 Avg Close $7.85 Range $6.63 - $10.09

Q2 2021

Shares 44,419 Value ($000) $399 Avg Close $9.52 Range $7.24 - $11.78

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	748,616	$3,721	$4.36	$3.03 - $5.78
Q3 2025	439,064	$1,383	$2.74	$2.02 - $3.49
Q3 2021	18,532	$158	$7.85	$6.63 - $10.09
Q2 2021	44,419	$399	$9.52	$7.24 - $11.78