ACHIEVE LIFE SCIENCES INC

Ticker: ACHV CUSIP: 004468500 Class: COM

TWO SIGMA ADVISERS, LP's Holding History (CIK: 0001478735)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 209,900 Value ($000) $1,043 Avg Close $4.36 Range $3.03 - $5.78

Q3 2025

Shares 110,300 Value ($000) $347 Avg Close $2.74 Range $2.02 - $3.49

Q1 2022

Shares 12,485 Value ($000) $95 Avg Close $7.45 Range $6.05 - $8.61

Q4 2021

Shares 17,255 Value ($000) $134 Avg Close $7.86 Range $6.55 - $9.21

Q3 2021

Shares 28,855 Value ($000) $245 Avg Close $7.85 Range $6.63 - $10.09

Q2 2021

Shares 43,255 Value ($000) $388 Avg Close $9.52 Range $7.24 - $11.78

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	209,900	$1,043	$4.36	$3.03 - $5.78
Q3 2025	110,300	$347	$2.74	$2.02 - $3.49
Q1 2022	12,485	$95	$7.45	$6.05 - $8.61
Q4 2021	17,255	$134	$7.86	$6.55 - $9.21
Q3 2021	28,855	$245	$7.85	$6.63 - $10.09
Q2 2021	43,255	$388	$9.52	$7.24 - $11.78