AEGLEA BIOTHERAPEUTICS INC

CUSIP: 00773J103 Class: COM

ADAGE CAPITAL PARTNERS GP, L.L.C.'s Holding History (CIK: 0001165408)

Note: Option positions (PUT/CALL) are excluded.

Q1 2023
Shares 1,500,000 Value ($000) $435 Avg Close — Range —
Q4 2022
Shares 1,500,000 Value ($000) $675 Avg Close — Range —
Q3 2022
Shares 1,500,000 Value ($000) $789 Avg Close — Range —
Q2 2022
Shares 1,500,000 Value ($000) $758 Avg Close — Range —
Q4 2021
Shares 1,000,000 Value ($000) $4,750 Avg Close — Range —
Q3 2021
Shares 3,500,000 Value ($000) $27,825 Avg Close — Range —
Q2 2021
Shares 3,049,581 Value ($000) $21,225 Avg Close — Range —
Q1 2021
Shares 2,948,141 Value ($000) $23,349 Avg Close — Range —
Q4 2020
Shares 2,992,000 Value ($000) $23,547 Avg Close — Range —
Q3 2020
Shares 2,992,000 Value ($000) $21,213 Avg Close — Range —
Q2 2020
Shares 2,892,000 Value ($000) $26,751 Avg Close — Range —
Q1 2020
Shares 1,468,591 Value ($000) $6,844 Avg Close — Range —
Q4 2019
Shares 1,468,591 Value ($000) $11,220 Avg Close — Range —
Q3 2019
Shares 1,468,591 Value ($000) $11,293 Avg Close — Range —
Q2 2019
Shares 1,468,591 Value ($000) $10,060 Avg Close — Range —
Q1 2019
Shares 1,468,591 Value ($000) $11,822 Avg Close — Range —
Q4 2018
Shares 1,458,591 Value ($000) $10,925 Avg Close — Range —
Q3 2018
Shares 915,702 Value ($000) $8,763 Avg Close — Range —
Q2 2018
Shares 890,702 Value ($000) $9,424 Avg Close — Range —
Q1 2018
Shares 250,000 Value ($000) $2,480 Avg Close — Range —