AEGLEA BIOTHERAPEUTICS INC

CUSIP: 00773J103 Class: COM

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q1 2023
Shares 320,498 Value ($000) $93 Avg Close — Range —
Q4 2022
Shares 393,638 Value ($000) $177 Avg Close — Range —
Q3 2022
Shares 103,589 Value ($000) $54 Avg Close — Range —
Q2 2022
Shares 315,840 Value ($000) $160 Avg Close — Range —
Q1 2022
Shares 216,601 Value ($000) $498 Avg Close — Range —
Q4 2021
Shares 64,511 Value ($000) $306 Avg Close — Range —
Q1 2021
Shares 18,332 Value ($000) $145 Avg Close — Range —
Q4 2020
Shares 64,263 Value ($000) $506 Avg Close — Range —
Q3 2020
Shares 140,772 Value ($000) $998 Avg Close — Range —
Q2 2020
Shares 82,427 Value ($000) $762 Avg Close — Range —
Q1 2020
Shares 35,421 Value ($000) $165 Avg Close — Range —
Q4 2019
Shares 49,622 Value ($000) $379 Avg Close — Range —
Q2 2019
Shares 49,458 Value ($000) $339 Avg Close — Range —
Q3 2018
Shares 26,382 Value ($000) $252 Avg Close — Range —