AERPIO PHARMACEUTICALS INC

CUSIP: 00810B105 Class: COM

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q3 2020
Shares 39,497 Value ($000) $59 Avg Close — Range —
Q1 2020
Shares 17,126 Value ($000) $9 Avg Close — Range —
Q4 2019
Shares 47,026 Value ($000) $29 Avg Close — Range —
Q3 2019
Shares 56,026 Value ($000) $38 Avg Close — Range —
Q2 2019
Shares 67,224 Value ($000) $61 Avg Close — Range —