AKCEA THERAPEUTICS INC

CUSIP: 00972L107 Class: COM

TWO SIGMA ADVISERS, LP's Holding History (CIK: 0001478735)

Note: Option positions (PUT/CALL) are excluded.

Q4 2018
Shares 12,000 Value ($000) $362 Avg Close — Range —
Q3 2018
Shares 14,200 Value ($000) $497 Avg Close — Range —