AKOUOS INC

CUSIP: 00973J101 Class: COM

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q3 2022
Shares 45,430 Value ($000) $307 Avg Close — Range —
Q1 2022
Shares 10,719 Value ($000) $51 Avg Close — Range —