ALEXZA PHARMACEUTICALS INC

CUSIP: 015384209 Class: CMN

MANUFACTURERS LIFE INSURANCE COMPANY, THE's Holding History (CIK: 0000928047)

Note: Option positions (PUT/CALL) are excluded.

Q1 2016
Shares 2,067 Value ($000) $1 Avg Close — Range —
Q4 2015
Shares 2,067 Value ($000) $1 Avg Close — Range —
Q3 2015
Shares 2,067 Value ($000) $3 Avg Close — Range —
Q2 2015
Shares 2,067 Value ($000) $2 Avg Close — Range —
Q1 2015
Shares 2,067 Value ($000) $4 Avg Close — Range —
Q4 2014
Shares 2,067 Value ($000) $3 Avg Close — Range —
Q3 2014
Shares 2,067 Value ($000) $5 Avg Close — Range —
Q2 2014
Shares 657 Value ($000) $3 Avg Close — Range —
Q1 2014
Shares 657 Value ($000) $3 Avg Close — Range —
Q4 2013
Shares 317 Value ($000) $1 Avg Close — Range —
Q3 2013
Shares 411 Value ($000) $2 Avg Close — Range —
Q2 2013
Shares 411 Value ($000) $2 Avg Close — Range —