ALNYLAM PHARMACEUTICALS INC

Ticker: ALNY CUSIP: 02043Q107 Class: EQTY

CULLEN/FROST BANKERS, INC.'s Holding History (CIK: 0000039263)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 11,033 Value ($000) $4,387 Avg Close $442.56 Range $387.03 - $495.55

Q3 2025

Shares 11,043 Value ($000) $5,036 Avg Close $407.20 Range $309.57 - $484.21

Q2 2025

Shares 10,795 Value ($000) $3,520 Avg Close $276.71 Range $205.87 - $327.21

Q1 2025

Shares 10,717 Value ($000) $2,894 Avg Close $257.00 Range $230.79 - $300.90

Q4 2024

Shares 10,639 Value ($000) $2,503 Avg Close $262.99 Range $229.86 - $304.39

Q3 2024

Shares 10,635 Value ($000) $2,925 Avg Close $260.36 Range $231.01 - $287.55

Q2 2024

Shares 10,555 Value ($000) $2,565 Avg Close $157.87 Range $141.98 - $252.87

Q1 2024

Shares 10,562 Value ($000) $1,578 Avg Close $166.82 Range $143.52 - $199.38

Q4 2023

Shares 10,549 Value ($000) $2,019 Avg Close $170.34 Range $148.10 - $198.00

Q3 2023

Shares 10,549 Value ($000) $1,868 Avg Close $191.12 Range $168.65 - $218.88

Q2 2023

Shares 10,549 Value ($000) $2,004 Avg Close $198.26 Range $183.00 - $212.47

Q1 2023

Shares 10,549 Value ($000) $2,113 Avg Close $210.20 Range $179.19 - $242.39

Q4 2022

Shares 10,549 Value ($000) $2,507 Avg Close $213.29 Range $181.65 - $242.97

Q3 2022

Shares 10,549 Value ($000) $2,111 Avg Close $190.74 Range $135.46 - $236.80

Q2 2022

Shares 10,949 Value ($000) $1,597 Avg Close $141.87 Range $117.58 - $180.35

Q1 2022

Shares 10,949 Value ($000) $1,788 Avg Close $152.35 Range $125.00 - $174.66

Q4 2021

Shares 10,549 Value ($000) $1,789 Avg Close $185.86 Range $154.82 - $212.00

Q3 2021

Shares 10,549 Value ($000) $1,992 Avg Close $187.58 Range $166.16 - $209.73

Q2 2021

Shares 10,549 Value ($000) $1,788 Avg Close $146.46 Range $125.08 - $177.53

Q1 2021

Shares 11,725 Value ($000) $1,655 Avg Close $150.49 Range $124.00 - $178.41

Q4 2020

Shares 11,725 Value ($000) $1,524 Avg Close $133.53 Range $119.29 - $148.76

Q3 2020

Shares 20,009 Value ($000) $2,913 Avg Close $142.10 Range $119.67 - $167.33

Q2 2020

Shares 20,849 Value ($000) $3,088 Avg Close $134.81 Range $98.01 - $158.37

Q1 2020

Shares 22,523 Value ($000) $2,452 Avg Close $115.43 Range $84.97 - $134.51

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	11,033	$4,387	$442.56	$387.03 - $495.55
Q3 2025	11,043	$5,036	$407.20	$309.57 - $484.21
Q2 2025	10,795	$3,520	$276.71	$205.87 - $327.21
Q1 2025	10,717	$2,894	$257.00	$230.79 - $300.90
Q4 2024	10,639	$2,503	$262.99	$229.86 - $304.39
Q3 2024	10,635	$2,925	$260.36	$231.01 - $287.55
Q2 2024	10,555	$2,565	$157.87	$141.98 - $252.87
Q1 2024	10,562	$1,578	$166.82	$143.52 - $199.38
Q4 2023	10,549	$2,019	$170.34	$148.10 - $198.00
Q3 2023	10,549	$1,868	$191.12	$168.65 - $218.88
Q2 2023	10,549	$2,004	$198.26	$183.00 - $212.47
Q1 2023	10,549	$2,113	$210.20	$179.19 - $242.39
Q4 2022	10,549	$2,507	$213.29	$181.65 - $242.97
Q3 2022	10,549	$2,111	$190.74	$135.46 - $236.80
Q2 2022	10,949	$1,597	$141.87	$117.58 - $180.35
Q1 2022	10,949	$1,788	$152.35	$125.00 - $174.66
Q4 2021	10,549	$1,789	$185.86	$154.82 - $212.00
Q3 2021	10,549	$1,992	$187.58	$166.16 - $209.73
Q2 2021	10,549	$1,788	$146.46	$125.08 - $177.53
Q1 2021	11,725	$1,655	$150.49	$124.00 - $178.41
Q4 2020	11,725	$1,524	$133.53	$119.29 - $148.76
Q3 2020	20,009	$2,913	$142.10	$119.67 - $167.33
Q2 2020	20,849	$3,088	$134.81	$98.01 - $158.37
Q1 2020	22,523	$2,452	$115.43	$84.97 - $134.51