ALNYLAM PHARMACEUTICALS INC

Ticker: ALNY CUSIP: 02043Q107 Class: EQTY

TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY's Holding History (CIK: 0000714142)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 31,616 Value ($000) $13 Avg Close $442.56 Range $387.03 - $495.55

Q3 2025

Shares 32,818 Value ($000) $15 Avg Close $407.20 Range $309.57 - $484.21

Q2 2025

Shares 33,218 Value ($000) $11 Avg Close $276.71 Range $205.87 - $327.21

Q1 2025

Shares 32,713 Value ($000) $9 Avg Close $257.00 Range $230.79 - $300.90

Q4 2024

Shares 34,713 Value ($000) $8 Avg Close $262.99 Range $229.86 - $304.39

Q3 2024

Shares 34,713 Value ($000) $10 Avg Close $260.36 Range $231.01 - $287.55

Q2 2024

Shares 33,213 Value ($000) $8 Avg Close $157.87 Range $141.98 - $252.87

Q1 2024

Shares 33,213 Value ($000) $5 Avg Close $166.82 Range $143.52 - $199.38

Q4 2023

Shares 30,713 Value ($000) $6 Avg Close $170.34 Range $148.10 - $198.00

Q3 2023

Shares 51,755 Value ($000) $9 Avg Close $191.12 Range $168.65 - $218.88

Q2 2023

Shares 52,091 Value ($000) $10 Avg Close $198.26 Range $183.00 - $212.47

Q1 2023

Shares 62,453 Value ($000) $13 Avg Close $210.20 Range $179.19 - $242.39

Q4 2022

Shares 61,053 Value ($000) $15 Avg Close $213.29 Range $181.65 - $242.97

Q3 2022

Shares 59,457 Value ($000) $11,900 Avg Close $190.74 Range $135.46 - $236.80

Q1 2022

Shares 66,123 Value ($000) $10,798 Avg Close $152.35 Range $125.00 - $174.66

Q4 2021

Shares 58,126 Value ($000) $9,856 Avg Close $185.86 Range $154.82 - $212.00

Q3 2021

Shares 52,291 Value ($000) $9,873 Avg Close $187.58 Range $166.16 - $209.73

Q2 2021

Shares 52,291 Value ($000) $8,864 Avg Close $146.46 Range $125.08 - $177.53

Q1 2021

Shares 52,216 Value ($000) $7,372 Avg Close $150.49 Range $124.00 - $178.41

Q4 2020

Shares 50,416 Value ($000) $6,552 Avg Close $133.53 Range $119.29 - $148.76

Q3 2020

Shares 50,416 Value ($000) $7,341 Avg Close $142.10 Range $119.67 - $167.33

Q2 2020

Shares 94,364 Value ($000) $13,977 Avg Close $134.81 Range $98.01 - $158.37

Q1 2020

Shares 116,491 Value ($000) $12,680 Avg Close $115.43 Range $84.97 - $134.51

Q4 2019

Shares 80,637 Value ($000) $9,286 Avg Close $99.70 Range $73.32 - $125.72

Q3 2019

Shares 76,206 Value ($000) $6,128 Avg Close $79.11 Range $69.11 - $88.00

Q2 2019

Shares 73,025 Value ($000) $5,299 Avg Close $76.72 Range $65.81 - $96.08

Q1 2019

Shares 72,780 Value ($000) $6,802 Avg Close $83.64 Range $70.29 - $93.95

Q4 2018

Shares 123,780 Value ($000) $9,024 Avg Close $76.92 Range $60.27 - $90.00

Q3 2018

Shares 99,403 Value ($000) $8,699 Avg Close $100.59 Range $86.95 - $124.22

Q2 2018

Shares 92,518 Value ($000) $9,112 Avg Close $99.19 Range $87.35 - $118.71

Q1 2018

Shares 76,442 Value ($000) $9,104 Avg Close $128.92 Range $108.13 - $153.99

Q4 2017

Shares 76,442 Value ($000) $9,712 Avg Close $125.65 Range $111.25 - $147.63

Q3 2017

Shares 134,688 Value ($000) $15,825 Avg Close $85.36 Range $70.76 - $119.02

Q2 2017

Shares 149,218 Value ($000) $11,901 Avg Close $63.91 Range $46.90 - $86.92

Q1 2017

Shares 208,176 Value ($000) $10,669 Avg Close $46.22 Range $35.98 - $60.41

Q4 2016

Shares 211,069 Value ($000) $7,902 Avg Close $41.87 Range $31.38 - $71.67

Q3 2016

Shares 193,983 Value ($000) $13,149 Avg Close $70.55 Range $53.56 - $80.11

Q2 2016

Shares 183,409 Value ($000) $10,177 Avg Close $63.00 Range $49.96 - $75.08

Q1 2016

Shares 181,035 Value ($000) $11,364 Avg Close $66.49 Range $51.51 - $98.00

Q4 2015

Shares 178,831 Value ($000) $16,835 Avg Close $92.72 Range $71.14 - $110.75

Q3 2015

Shares 167,151 Value ($000) $13,432 Avg Close $111.10 Range $76.46 - $137.89

Q2 2015

Shares 174,256 Value ($000) $20,888 Avg Close $119.50 Range $98.63 - $140.00

Q1 2015

Shares 188,535 Value ($000) $19,686 Avg Close $101.34 Range $82.06 - $121.93

Q4 2014

Shares 145,695 Value ($000) $14,133 Avg Close $92.65 Range $72.80 - $111.49

Q3 2014

Shares 152,550 Value ($000) $11,914 Avg Close $64.51 Range $51.93 - $79.88

Q2 2014

Shares 159,040 Value ($000) $10,047 Avg Close $59.44 Range $47.03 - $71.40

Q1 2014

Shares 142,050 Value ($000) $9,537 Avg Close $77.42 Range $60.24 - $112.57

Q4 2013

Shares 156,960 Value ($000) $10,092 Avg Close $59.65 Range $48.16 - $67.97

Q3 2013

Shares 125,210 Value ($000) $8,015 Avg Close $49.85 Range $31.75 - $65.83

Q2 2013

Shares 126,700 Value ($000) $3,928 Avg Close $26.61 Range $21.60 - $31.79

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	31,616	$13	$442.56	$387.03 - $495.55
Q3 2025	32,818	$15	$407.20	$309.57 - $484.21
Q2 2025	33,218	$11	$276.71	$205.87 - $327.21
Q1 2025	32,713	$9	$257.00	$230.79 - $300.90
Q4 2024	34,713	$8	$262.99	$229.86 - $304.39
Q3 2024	34,713	$10	$260.36	$231.01 - $287.55
Q2 2024	33,213	$8	$157.87	$141.98 - $252.87
Q1 2024	33,213	$5	$166.82	$143.52 - $199.38
Q4 2023	30,713	$6	$170.34	$148.10 - $198.00
Q3 2023	51,755	$9	$191.12	$168.65 - $218.88
Q2 2023	52,091	$10	$198.26	$183.00 - $212.47
Q1 2023	62,453	$13	$210.20	$179.19 - $242.39
Q4 2022	61,053	$15	$213.29	$181.65 - $242.97
Q3 2022	59,457	$11,900	$190.74	$135.46 - $236.80
Q1 2022	66,123	$10,798	$152.35	$125.00 - $174.66
Q4 2021	58,126	$9,856	$185.86	$154.82 - $212.00
Q3 2021	52,291	$9,873	$187.58	$166.16 - $209.73
Q2 2021	52,291	$8,864	$146.46	$125.08 - $177.53
Q1 2021	52,216	$7,372	$150.49	$124.00 - $178.41
Q4 2020	50,416	$6,552	$133.53	$119.29 - $148.76
Q3 2020	50,416	$7,341	$142.10	$119.67 - $167.33
Q2 2020	94,364	$13,977	$134.81	$98.01 - $158.37
Q1 2020	116,491	$12,680	$115.43	$84.97 - $134.51
Q4 2019	80,637	$9,286	$99.70	$73.32 - $125.72
Q3 2019	76,206	$6,128	$79.11	$69.11 - $88.00
Q2 2019	73,025	$5,299	$76.72	$65.81 - $96.08
Q1 2019	72,780	$6,802	$83.64	$70.29 - $93.95
Q4 2018	123,780	$9,024	$76.92	$60.27 - $90.00
Q3 2018	99,403	$8,699	$100.59	$86.95 - $124.22
Q2 2018	92,518	$9,112	$99.19	$87.35 - $118.71
Q1 2018	76,442	$9,104	$128.92	$108.13 - $153.99
Q4 2017	76,442	$9,712	$125.65	$111.25 - $147.63
Q3 2017	134,688	$15,825	$85.36	$70.76 - $119.02
Q2 2017	149,218	$11,901	$63.91	$46.90 - $86.92
Q1 2017	208,176	$10,669	$46.22	$35.98 - $60.41
Q4 2016	211,069	$7,902	$41.87	$31.38 - $71.67
Q3 2016	193,983	$13,149	$70.55	$53.56 - $80.11
Q2 2016	183,409	$10,177	$63.00	$49.96 - $75.08
Q1 2016	181,035	$11,364	$66.49	$51.51 - $98.00
Q4 2015	178,831	$16,835	$92.72	$71.14 - $110.75
Q3 2015	167,151	$13,432	$111.10	$76.46 - $137.89
Q2 2015	174,256	$20,888	$119.50	$98.63 - $140.00
Q1 2015	188,535	$19,686	$101.34	$82.06 - $121.93
Q4 2014	145,695	$14,133	$92.65	$72.80 - $111.49
Q3 2014	152,550	$11,914	$64.51	$51.93 - $79.88
Q2 2014	159,040	$10,047	$59.44	$47.03 - $71.40
Q1 2014	142,050	$9,537	$77.42	$60.24 - $112.57
Q4 2013	156,960	$10,092	$59.65	$48.16 - $67.97
Q3 2013	125,210	$8,015	$49.85	$31.75 - $65.83
Q2 2013	126,700	$3,928	$26.61	$21.60 - $31.79