ALNYLAM PHARMACEUTICALS INC

Ticker: ALNY CUSIP: 02043Q107 Class: EQTY

TEACHER RETIREMENT SYSTEM OF TEXAS's Holding History (CIK: 0000796848)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 20,035 Value ($000) $7,967 Avg Close $442.56 Range $387.03 - $495.55

Q3 2025

Shares 33,642 Value ($000) $15,341 Avg Close $407.20 Range $309.57 - $484.21

Q2 2025

Shares 36,408 Value ($000) $11,872 Avg Close $276.71 Range $205.87 - $327.21

Q1 2025

Shares 35,285 Value ($000) $9,528 Avg Close $257.00 Range $230.79 - $300.90

Q4 2024

Shares 39,075 Value ($000) $9 Avg Close $262.99 Range $229.86 - $304.39

Q3 2024

Shares 33,650 Value ($000) $9 Avg Close $260.36 Range $231.01 - $287.55

Q2 2024

Shares 29,365 Value ($000) $7 Avg Close $157.87 Range $141.98 - $252.87

Q1 2024

Shares 28,533 Value ($000) $4 Avg Close $166.82 Range $143.52 - $199.38

Q4 2023

Shares 29,214 Value ($000) $6 Avg Close $170.34 Range $148.10 - $198.00

Q3 2023

Shares 32,958 Value ($000) $6 Avg Close $191.12 Range $168.65 - $218.88

Q2 2023

Shares 32,266 Value ($000) $6 Avg Close $198.26 Range $183.00 - $212.47

Q1 2023

Shares 28,787 Value ($000) $6 Avg Close $210.20 Range $179.19 - $242.39

Q4 2022

Shares 13,365 Value ($000) $3 Avg Close $213.29 Range $181.65 - $242.97

Q3 2022

Shares 17,374 Value ($000) $3,478 Avg Close $190.74 Range $135.46 - $236.80

Q2 2022

Shares 18,428 Value ($000) $2,688 Avg Close $141.87 Range $117.58 - $180.35

Q1 2022

Shares 24,543 Value ($000) $4,008 Avg Close $152.35 Range $125.00 - $174.66

Q4 2021

Shares 22,638 Value ($000) $3,839 Avg Close $185.86 Range $154.82 - $212.00

Q3 2021

Shares 29,435 Value ($000) $5,558 Avg Close $187.58 Range $166.16 - $209.73

Q2 2021

Shares 15,116 Value ($000) $2,562 Avg Close $146.46 Range $125.08 - $177.53

Q1 2021

Shares 12,841 Value ($000) $1,813 Avg Close $150.49 Range $124.00 - $178.41

Q4 2020

Shares 10,461 Value ($000) $1,360 Avg Close $133.53 Range $119.29 - $148.76

Q3 2020

Shares 28,679 Value ($000) $4,176 Avg Close $142.10 Range $119.67 - $167.33

Q2 2020

Shares 46,818 Value ($000) $6,934 Avg Close $134.81 Range $98.01 - $158.37

Q3 2019

Shares 13,049 Value ($000) $1,049 Avg Close $79.11 Range $69.11 - $88.00

Q2 2019

Shares 15,622 Value ($000) $1,134 Avg Close $76.72 Range $65.81 - $96.08

Q1 2019

Shares 11,895 Value ($000) $1,112 Avg Close $83.64 Range $70.29 - $93.95

Q4 2018

Shares 12,984 Value ($000) $947 Avg Close $76.92 Range $60.27 - $90.00

Q3 2018

Shares 19,797 Value ($000) $1,733 Avg Close $100.59 Range $86.95 - $124.22

Q2 2018

Shares 24,093 Value ($000) $2,373 Avg Close $99.19 Range $87.35 - $118.71

Q1 2018

Shares 19,515 Value ($000) $2,324 Avg Close $128.92 Range $108.13 - $153.99

Q4 2017

Shares 24,050 Value ($000) $3,056 Avg Close $125.65 Range $111.25 - $147.63

Q3 2017

Shares 6,748 Value ($000) $793 Avg Close $85.36 Range $70.76 - $119.02

Q2 2017

Shares 6,481 Value ($000) $517 Avg Close $63.91 Range $46.90 - $86.92

Q1 2017

Shares 5,943 Value ($000) $305 Avg Close $46.22 Range $35.98 - $60.41

Q4 2016

Shares 6,239 Value ($000) $234 Avg Close $41.87 Range $31.38 - $71.67

Q3 2016

Shares 3,040 Value ($000) $206 Avg Close $70.55 Range $53.56 - $80.11

Q2 2016

Shares 5,444 Value ($000) $302 Avg Close $63.00 Range $49.96 - $75.08

Q1 2016

Shares 4,153 Value ($000) $261 Avg Close $66.49 Range $51.51 - $98.00

Q4 2015

Shares 1,857 Value ($000) $175 Avg Close $92.72 Range $71.14 - $110.75

Q3 2015

Shares 4,061 Value ($000) $326 Avg Close $111.10 Range $76.46 - $137.89

Q2 2015

Shares 2,900 Value ($000) $348 Avg Close $119.50 Range $98.63 - $140.00

Q1 2015

Shares 2,257 Value ($000) $236 Avg Close $101.34 Range $82.06 - $121.93

Q4 2014

Shares 1,966 Value ($000) $191 Avg Close $92.65 Range $72.80 - $111.49

Q3 2014

Shares 1,903 Value ($000) $149 Avg Close $64.51 Range $51.93 - $79.88

Q2 2014

Shares 2,036 Value ($000) $129 Avg Close $59.44 Range $47.03 - $71.40

Q1 2014

Shares 2,199 Value ($000) $148 Avg Close $77.42 Range $60.24 - $112.57

Q4 2013

Shares 2,115 Value ($000) $136 Avg Close $59.65 Range $48.16 - $67.97

Q3 2013

Shares 7,050 Value ($000) $451 Avg Close $49.85 Range $31.75 - $65.83

Q2 2013

Shares 3,792 Value ($000) $118 Avg Close $26.61 Range $21.60 - $31.79

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	20,035	$7,967	$442.56	$387.03 - $495.55
Q3 2025	33,642	$15,341	$407.20	$309.57 - $484.21
Q2 2025	36,408	$11,872	$276.71	$205.87 - $327.21
Q1 2025	35,285	$9,528	$257.00	$230.79 - $300.90
Q4 2024	39,075	$9	$262.99	$229.86 - $304.39
Q3 2024	33,650	$9	$260.36	$231.01 - $287.55
Q2 2024	29,365	$7	$157.87	$141.98 - $252.87
Q1 2024	28,533	$4	$166.82	$143.52 - $199.38
Q4 2023	29,214	$6	$170.34	$148.10 - $198.00
Q3 2023	32,958	$6	$191.12	$168.65 - $218.88
Q2 2023	32,266	$6	$198.26	$183.00 - $212.47
Q1 2023	28,787	$6	$210.20	$179.19 - $242.39
Q4 2022	13,365	$3	$213.29	$181.65 - $242.97
Q3 2022	17,374	$3,478	$190.74	$135.46 - $236.80
Q2 2022	18,428	$2,688	$141.87	$117.58 - $180.35
Q1 2022	24,543	$4,008	$152.35	$125.00 - $174.66
Q4 2021	22,638	$3,839	$185.86	$154.82 - $212.00
Q3 2021	29,435	$5,558	$187.58	$166.16 - $209.73
Q2 2021	15,116	$2,562	$146.46	$125.08 - $177.53
Q1 2021	12,841	$1,813	$150.49	$124.00 - $178.41
Q4 2020	10,461	$1,360	$133.53	$119.29 - $148.76
Q3 2020	28,679	$4,176	$142.10	$119.67 - $167.33
Q2 2020	46,818	$6,934	$134.81	$98.01 - $158.37
Q3 2019	13,049	$1,049	$79.11	$69.11 - $88.00
Q2 2019	15,622	$1,134	$76.72	$65.81 - $96.08
Q1 2019	11,895	$1,112	$83.64	$70.29 - $93.95
Q4 2018	12,984	$947	$76.92	$60.27 - $90.00
Q3 2018	19,797	$1,733	$100.59	$86.95 - $124.22
Q2 2018	24,093	$2,373	$99.19	$87.35 - $118.71
Q1 2018	19,515	$2,324	$128.92	$108.13 - $153.99
Q4 2017	24,050	$3,056	$125.65	$111.25 - $147.63
Q3 2017	6,748	$793	$85.36	$70.76 - $119.02
Q2 2017	6,481	$517	$63.91	$46.90 - $86.92
Q1 2017	5,943	$305	$46.22	$35.98 - $60.41
Q4 2016	6,239	$234	$41.87	$31.38 - $71.67
Q3 2016	3,040	$206	$70.55	$53.56 - $80.11
Q2 2016	5,444	$302	$63.00	$49.96 - $75.08
Q1 2016	4,153	$261	$66.49	$51.51 - $98.00
Q4 2015	1,857	$175	$92.72	$71.14 - $110.75
Q3 2015	4,061	$326	$111.10	$76.46 - $137.89
Q2 2015	2,900	$348	$119.50	$98.63 - $140.00
Q1 2015	2,257	$236	$101.34	$82.06 - $121.93
Q4 2014	1,966	$191	$92.65	$72.80 - $111.49
Q3 2014	1,903	$149	$64.51	$51.93 - $79.88
Q2 2014	2,036	$129	$59.44	$47.03 - $71.40
Q1 2014	2,199	$148	$77.42	$60.24 - $112.57
Q4 2013	2,115	$136	$59.65	$48.16 - $67.97
Q3 2013	7,050	$451	$49.85	$31.75 - $65.83
Q2 2013	3,792	$118	$26.61	$21.60 - $31.79