ALNYLAM PHARMACEUTICALS INC

Ticker: ALNY CUSIP: 02043Q107 Class: EQTY

CHARLES SCHWAB INVESTMENT MANAGEMENT INC's Holding History (CIK: 0000884546)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 647,839 Value ($000) $257,613 Avg Close $442.56 Range $387.03 - $495.55

Q3 2025

Shares 618,770 Value ($000) $282,159 Avg Close $407.20 Range $309.57 - $484.21

Q2 2025

Shares 571,747 Value ($000) $186,441 Avg Close $276.71 Range $205.87 - $327.21

Q1 2025

Shares 546,642 Value ($000) $147,604 Avg Close $257.00 Range $230.79 - $300.90

Q4 2024

Shares 513,962 Value ($000) $120,940 Avg Close $262.99 Range $229.86 - $304.39

Q3 2024

Shares 487,348 Value ($000) $134,035 Avg Close $260.36 Range $231.01 - $287.55

Q2 2024

Shares 470,592 Value ($000) $114,354 Avg Close $157.87 Range $141.98 - $252.87

Q1 2024

Shares 447,560 Value ($000) $66,888 Avg Close $166.82 Range $143.52 - $199.38

Q4 2023

Shares 438,304 Value ($000) $83,896 Avg Close $170.34 Range $148.10 - $198.00

Q3 2023

Shares 418,980 Value ($000) $74,201 Avg Close $191.12 Range $168.65 - $218.88

Q2 2023

Shares 416,144 Value ($000) $79,042 Avg Close $198.26 Range $183.00 - $212.47

Q1 2023

Shares 405,363 Value ($000) $81,202 Avg Close $210.20 Range $179.19 - $242.39

Q4 2022

Shares 400,576 Value ($000) $95,197 Avg Close $213.29 Range $181.65 - $242.97

Q3 2022

Shares 378,865 Value ($000) $75,834 Avg Close $190.74 Range $135.46 - $236.80

Q2 2022

Shares 376,297 Value ($000) $54,883 Avg Close $141.87 Range $117.58 - $180.35

Q1 2022

Shares 372,623 Value ($000) $60,846 Avg Close $152.35 Range $125.00 - $174.66

Q4 2021

Shares 362,961 Value ($000) $61,551 Avg Close $185.86 Range $154.82 - $212.00

Q3 2021

Shares 352,815 Value ($000) $66,615 Avg Close $187.58 Range $166.16 - $209.73

Q2 2021

Shares 343,331 Value ($000) $58,202 Avg Close $146.46 Range $125.08 - $177.53

Q1 2021

Shares 334,213 Value ($000) $47,188 Avg Close $150.49 Range $124.00 - $178.41

Q4 2020

Shares 400,276 Value ($000) $52,024 Avg Close $133.53 Range $119.29 - $148.76

Q3 2020

Shares 400,579 Value ($000) $58,325 Avg Close $142.10 Range $119.67 - $167.33

Q2 2020

Shares 629,644 Value ($000) $93,257 Avg Close $134.81 Range $98.01 - $158.37

Q1 2020

Shares 610,819 Value ($000) $66,488 Avg Close $115.43 Range $84.97 - $134.51

Q4 2019

Shares 600,778 Value ($000) $69,192 Avg Close $99.70 Range $73.32 - $125.72

Q3 2019

Shares 591,500 Value ($000) $47,569 Avg Close $79.11 Range $69.11 - $88.00

Q2 2019

Shares 492,175 Value ($000) $35,713 Avg Close $76.72 Range $65.81 - $96.08

Q1 2019

Shares 471,024 Value ($000) $44,018 Avg Close $83.64 Range $70.29 - $93.95

Q4 2018

Shares 356,145 Value ($000) $25,967 Avg Close $76.92 Range $60.27 - $90.00

Q3 2018

Shares 343,046 Value ($000) $30,024 Avg Close $100.59 Range $86.95 - $124.22

Q2 2018

Shares 304,233 Value ($000) $29,964 Avg Close $99.19 Range $87.35 - $118.71

Q1 2018

Shares 277,352 Value ($000) $33,033 Avg Close $128.92 Range $108.13 - $153.99

Q4 2017

Shares 262,416 Value ($000) $33,340 Avg Close $125.65 Range $111.25 - $147.63

Q3 2017

Shares 244,550 Value ($000) $28,733 Avg Close $85.36 Range $70.76 - $119.02

Q2 2017

Shares 243,415 Value ($000) $19,415 Avg Close $63.91 Range $46.90 - $86.92

Q1 2017

Shares 182,509 Value ($000) $9,354 Avg Close $46.22 Range $35.98 - $60.41

Q4 2016

Shares 192,542 Value ($000) $7,209 Avg Close $41.87 Range $31.38 - $71.67

Q3 2016

Shares 165,993 Value ($000) $11,252 Avg Close $70.55 Range $53.56 - $80.11

Q2 2016

Shares 95,254 Value ($000) $5,286 Avg Close $63.00 Range $49.96 - $75.08

Q1 2016

Shares 98,040 Value ($000) $6,154 Avg Close $66.49 Range $51.51 - $98.00

Q4 2015

Shares 95,687 Value ($000) $9,008 Avg Close $92.72 Range $71.14 - $110.75

Q3 2015

Shares 88,548 Value ($000) $7,116 Avg Close $111.10 Range $76.46 - $137.89

Q2 2015

Shares 131,720 Value ($000) $15,790 Avg Close $119.50 Range $98.63 - $140.00

Q1 2015

Shares 122,931 Value ($000) $12,837 Avg Close $101.34 Range $82.06 - $121.93

Q4 2014

Shares 105,383 Value ($000) $10,223 Avg Close $92.65 Range $72.80 - $111.49

Q3 2014

Shares 93,985 Value ($000) $7,341 Avg Close $64.51 Range $51.93 - $79.88

Q2 2014

Shares 88,748 Value ($000) $5,607 Avg Close $59.44 Range $47.03 - $71.40

Q1 2014

Shares 166,989 Value ($000) $11,212 Avg Close $77.42 Range $60.24 - $112.57

Q4 2013

Shares 142,535 Value ($000) $9,170 Avg Close $59.65 Range $48.16 - $67.97

Q3 2013

Shares 135,357 Value ($000) $8,911 Avg Close $49.85 Range $31.75 - $65.83

Q2 2013

Shares 129,143 Value ($000) $4,261 Avg Close $26.61 Range $21.60 - $31.79

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	647,839	$257,613	$442.56	$387.03 - $495.55
Q3 2025	618,770	$282,159	$407.20	$309.57 - $484.21
Q2 2025	571,747	$186,441	$276.71	$205.87 - $327.21
Q1 2025	546,642	$147,604	$257.00	$230.79 - $300.90
Q4 2024	513,962	$120,940	$262.99	$229.86 - $304.39
Q3 2024	487,348	$134,035	$260.36	$231.01 - $287.55
Q2 2024	470,592	$114,354	$157.87	$141.98 - $252.87
Q1 2024	447,560	$66,888	$166.82	$143.52 - $199.38
Q4 2023	438,304	$83,896	$170.34	$148.10 - $198.00
Q3 2023	418,980	$74,201	$191.12	$168.65 - $218.88
Q2 2023	416,144	$79,042	$198.26	$183.00 - $212.47
Q1 2023	405,363	$81,202	$210.20	$179.19 - $242.39
Q4 2022	400,576	$95,197	$213.29	$181.65 - $242.97
Q3 2022	378,865	$75,834	$190.74	$135.46 - $236.80
Q2 2022	376,297	$54,883	$141.87	$117.58 - $180.35
Q1 2022	372,623	$60,846	$152.35	$125.00 - $174.66
Q4 2021	362,961	$61,551	$185.86	$154.82 - $212.00
Q3 2021	352,815	$66,615	$187.58	$166.16 - $209.73
Q2 2021	343,331	$58,202	$146.46	$125.08 - $177.53
Q1 2021	334,213	$47,188	$150.49	$124.00 - $178.41
Q4 2020	400,276	$52,024	$133.53	$119.29 - $148.76
Q3 2020	400,579	$58,325	$142.10	$119.67 - $167.33
Q2 2020	629,644	$93,257	$134.81	$98.01 - $158.37
Q1 2020	610,819	$66,488	$115.43	$84.97 - $134.51
Q4 2019	600,778	$69,192	$99.70	$73.32 - $125.72
Q3 2019	591,500	$47,569	$79.11	$69.11 - $88.00
Q2 2019	492,175	$35,713	$76.72	$65.81 - $96.08
Q1 2019	471,024	$44,018	$83.64	$70.29 - $93.95
Q4 2018	356,145	$25,967	$76.92	$60.27 - $90.00
Q3 2018	343,046	$30,024	$100.59	$86.95 - $124.22
Q2 2018	304,233	$29,964	$99.19	$87.35 - $118.71
Q1 2018	277,352	$33,033	$128.92	$108.13 - $153.99
Q4 2017	262,416	$33,340	$125.65	$111.25 - $147.63
Q3 2017	244,550	$28,733	$85.36	$70.76 - $119.02
Q2 2017	243,415	$19,415	$63.91	$46.90 - $86.92
Q1 2017	182,509	$9,354	$46.22	$35.98 - $60.41
Q4 2016	192,542	$7,209	$41.87	$31.38 - $71.67
Q3 2016	165,993	$11,252	$70.55	$53.56 - $80.11
Q2 2016	95,254	$5,286	$63.00	$49.96 - $75.08
Q1 2016	98,040	$6,154	$66.49	$51.51 - $98.00
Q4 2015	95,687	$9,008	$92.72	$71.14 - $110.75
Q3 2015	88,548	$7,116	$111.10	$76.46 - $137.89
Q2 2015	131,720	$15,790	$119.50	$98.63 - $140.00
Q1 2015	122,931	$12,837	$101.34	$82.06 - $121.93
Q4 2014	105,383	$10,223	$92.65	$72.80 - $111.49
Q3 2014	93,985	$7,341	$64.51	$51.93 - $79.88
Q2 2014	88,748	$5,607	$59.44	$47.03 - $71.40
Q1 2014	166,989	$11,212	$77.42	$60.24 - $112.57
Q4 2013	142,535	$9,170	$59.65	$48.16 - $67.97
Q3 2013	135,357	$8,911	$49.85	$31.75 - $65.83
Q2 2013	129,143	$4,261	$26.61	$21.60 - $31.79