ALNYLAM PHARMACEUTICALS INC

Ticker: ALNY CUSIP: 02043Q107 Class: EQTY

CAISSE DE DEPOT ET PLACEMENT DU QUEBEC's Holding History (CIK: 0000898286)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 51,598 Value ($000) $20,518 Avg Close $442.56 Range $387.03 - $495.55

Q3 2025

Shares 17,826 Value ($000) $8,129 Avg Close $407.20 Range $309.57 - $484.21

Q2 2025

Shares 20,044 Value ($000) $6,536 Avg Close $276.71 Range $205.87 - $327.21

Q1 2025

Shares 23,763 Value ($000) $6,416 Avg Close $257.00 Range $230.79 - $300.90

Q4 2024

Shares 10,018 Value ($000) $2,357 Avg Close $262.99 Range $229.86 - $304.39

Q3 2024

Shares 25,295 Value ($000) $6,957 Avg Close $260.36 Range $231.01 - $287.55

Q2 2024

Shares 25,295 Value ($000) $6,147 Avg Close $157.87 Range $141.98 - $252.87

Q1 2024

Shares 24,795 Value ($000) $3,706 Avg Close $166.82 Range $143.52 - $199.38

Q4 2023

Shares 19,595 Value ($000) $3,751 Avg Close $170.34 Range $148.10 - $198.00

Q3 2023

Shares 12,711 Value ($000) $2,251 Avg Close $191.12 Range $168.65 - $218.88

Q2 2023

Shares 12,711 Value ($000) $2,414 Avg Close $198.26 Range $183.00 - $212.47

Q1 2023

Shares 14,900 Value ($000) $2,985 Avg Close $210.20 Range $179.19 - $242.39

Q4 2022

Shares 14,900 Value ($000) $3,541 Avg Close $213.29 Range $181.65 - $242.97

Q2 2022

Shares 1,794 Value ($000) $262 Avg Close $141.87 Range $117.58 - $180.35

Q1 2021

Shares 1,687 Value ($000) $238 Avg Close $150.49 Range $124.00 - $178.41

Q4 2020

Shares 40,623 Value ($000) $5,280 Avg Close $133.53 Range $119.29 - $148.76

Q3 2020

Shares 2,700 Value ($000) $393 Avg Close $142.10 Range $119.67 - $167.33

Q2 2020

Shares 2,900 Value ($000) $430 Avg Close $134.81 Range $98.01 - $158.37

Q1 2020

Shares 4,100 Value ($000) $446 Avg Close $115.43 Range $84.97 - $134.51

Q4 2019

Shares 4,100 Value ($000) $472 Avg Close $99.70 Range $73.32 - $125.72

Q3 2019

Shares 5,400 Value ($000) $434 Avg Close $79.11 Range $69.11 - $88.00

Q2 2019

Shares 5,200 Value ($000) $377 Avg Close $76.72 Range $65.81 - $96.08

Q1 2019

Shares 5,500 Value ($000) $514 Avg Close $83.64 Range $70.29 - $93.95

Q4 2018

Shares 190,000 Value ($000) $13,853 Avg Close $76.92 Range $60.27 - $90.00

Q3 2018

Shares 2,700 Value ($000) $236 Avg Close $100.59 Range $86.95 - $124.22

Q2 2018

Shares 2,800 Value ($000) $276 Avg Close $99.19 Range $87.35 - $118.71

Q3 2016

Shares 9,500 Value ($000) $644 Avg Close $70.55 Range $53.56 - $80.11

Q2 2016

Shares 10,200 Value ($000) $566 Avg Close $63.00 Range $49.96 - $75.08

Q1 2016

Shares 5,300 Value ($000) $333 Avg Close $66.49 Range $51.51 - $98.00

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	51,598	$20,518	$442.56	$387.03 - $495.55
Q3 2025	17,826	$8,129	$407.20	$309.57 - $484.21
Q2 2025	20,044	$6,536	$276.71	$205.87 - $327.21
Q1 2025	23,763	$6,416	$257.00	$230.79 - $300.90
Q4 2024	10,018	$2,357	$262.99	$229.86 - $304.39
Q3 2024	25,295	$6,957	$260.36	$231.01 - $287.55
Q2 2024	25,295	$6,147	$157.87	$141.98 - $252.87
Q1 2024	24,795	$3,706	$166.82	$143.52 - $199.38
Q4 2023	19,595	$3,751	$170.34	$148.10 - $198.00
Q3 2023	12,711	$2,251	$191.12	$168.65 - $218.88
Q2 2023	12,711	$2,414	$198.26	$183.00 - $212.47
Q1 2023	14,900	$2,985	$210.20	$179.19 - $242.39
Q4 2022	14,900	$3,541	$213.29	$181.65 - $242.97
Q2 2022	1,794	$262	$141.87	$117.58 - $180.35
Q1 2021	1,687	$238	$150.49	$124.00 - $178.41
Q4 2020	40,623	$5,280	$133.53	$119.29 - $148.76
Q3 2020	2,700	$393	$142.10	$119.67 - $167.33
Q2 2020	2,900	$430	$134.81	$98.01 - $158.37
Q1 2020	4,100	$446	$115.43	$84.97 - $134.51
Q4 2019	4,100	$472	$99.70	$73.32 - $125.72
Q3 2019	5,400	$434	$79.11	$69.11 - $88.00
Q2 2019	5,200	$377	$76.72	$65.81 - $96.08
Q1 2019	5,500	$514	$83.64	$70.29 - $93.95
Q4 2018	190,000	$13,853	$76.92	$60.27 - $90.00
Q3 2018	2,700	$236	$100.59	$86.95 - $124.22
Q2 2018	2,800	$276	$99.19	$87.35 - $118.71
Q3 2016	9,500	$644	$70.55	$53.56 - $80.11
Q2 2016	10,200	$566	$63.00	$49.96 - $75.08
Q1 2016	5,300	$333	$66.49	$51.51 - $98.00