ALNYLAM PHARMACEUTICALS INC

Ticker: ALNY CUSIP: 02043Q107 Class: EQTY

CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM's Holding History (CIK: 0000919079)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 237,005 Value ($000) $94,245 Avg Close $442.56 Range $387.03 - $495.55

Q3 2025

Shares 229,641 Value ($000) $104,716 Avg Close $407.20 Range $309.57 - $484.21

Q2 2025

Shares 211,581 Value ($000) $68,994 Avg Close $276.71 Range $205.87 - $327.21

Q1 2025

Shares 201,481 Value ($000) $54,404 Avg Close $257.00 Range $230.79 - $300.90

Q4 2024

Shares 204,132 Value ($000) $48,034 Avg Close $262.99 Range $229.86 - $304.39

Q3 2024

Shares 211,781 Value ($000) $58,246 Avg Close $260.36 Range $231.01 - $287.55

Q2 2024

Shares 215,567 Value ($000) $52,383 Avg Close $157.87 Range $141.98 - $252.87

Q1 2024

Shares 214,330 Value ($000) $32,032 Avg Close $166.82 Range $143.52 - $199.38

Q4 2023

Shares 179,330 Value ($000) $34,326 Avg Close $170.34 Range $148.10 - $198.00

Q3 2023

Shares 227,830 Value ($000) $40,349 Avg Close $191.12 Range $168.65 - $218.88

Q2 2023

Shares 226,279 Value ($000) $42,979 Avg Close $198.26 Range $183.00 - $212.47

Q1 2023

Shares 237,113 Value ($000) $47,498 Avg Close $210.20 Range $179.19 - $242.39

Q4 2022

Shares 270,883 Value ($000) $64,375 Avg Close $213.29 Range $181.65 - $242.97

Q3 2022

Shares 269,760 Value ($000) $53,995 Avg Close $190.74 Range $135.46 - $236.80

Q2 2022

Shares 236,555 Value ($000) $34,502 Avg Close $141.87 Range $117.58 - $180.35

Q1 2022

Shares 245,603 Value ($000) $40,105 Avg Close $152.35 Range $125.00 - $174.66

Q4 2021

Shares 309,675 Value ($000) $52,515 Avg Close $185.86 Range $154.82 - $212.00

Q3 2021

Shares 318,959 Value ($000) $60,223 Avg Close $187.58 Range $166.16 - $209.73

Q2 2021

Shares 317,692 Value ($000) $53,855 Avg Close $146.46 Range $125.08 - $177.53

Q1 2021

Shares 320,047 Value ($000) $45,187 Avg Close $150.49 Range $124.00 - $178.41

Q4 2020

Shares 333,740 Value ($000) $43,376 Avg Close $133.53 Range $119.29 - $148.76

Q3 2020

Shares 264,351 Value ($000) $38,490 Avg Close $142.10 Range $119.67 - $167.33

Q2 2020

Shares 255,768 Value ($000) $37,882 Avg Close $134.81 Range $98.01 - $158.37

Q1 2020

Shares 220,800 Value ($000) $24,034 Avg Close $115.43 Range $84.97 - $134.51

Q4 2019

Shares 224,300 Value ($000) $25,833 Avg Close $99.70 Range $73.32 - $125.72

Q3 2019

Shares 177,600 Value ($000) $14,283 Avg Close $79.11 Range $69.11 - $88.00

Q2 2019

Shares 121,400 Value ($000) $8,809 Avg Close $76.72 Range $65.81 - $96.08

Q1 2019

Shares 177,786 Value ($000) $16,614 Avg Close $83.64 Range $70.29 - $93.95

Q4 2018

Shares 184,959 Value ($000) $13,485 Avg Close $76.92 Range $60.27 - $90.00

Q3 2018

Shares 182,535 Value ($000) $15,975 Avg Close $100.59 Range $86.95 - $124.22

Q2 2018

Shares 208,514 Value ($000) $20,537 Avg Close $99.19 Range $87.35 - $118.71

Q1 2018

Shares 218,599 Value ($000) $26,035 Avg Close $128.92 Range $108.13 - $153.99

Q4 2017

Shares 196,038 Value ($000) $24,907 Avg Close $125.65 Range $111.25 - $147.63

Q3 2017

Shares 133,206 Value ($000) $15,650 Avg Close $85.36 Range $70.76 - $119.02

Q2 2017

Shares 126,700 Value ($000) $10,106 Avg Close $63.91 Range $46.90 - $86.92

Q1 2017

Shares 110,800 Value ($000) $5,679 Avg Close $46.22 Range $35.98 - $60.41

Q4 2016

Shares 115,600 Value ($000) $4,328 Avg Close $41.87 Range $31.38 - $71.67

Q3 2016

Shares 115,600 Value ($000) $7,835 Avg Close $70.55 Range $53.56 - $80.11

Q2 2016

Shares 123,600 Value ($000) $6,859 Avg Close $63.00 Range $49.96 - $75.08

Q1 2016

Shares 127,500 Value ($000) $8,003 Avg Close $66.49 Range $51.51 - $98.00

Q4 2015

Shares 146,500 Value ($000) $13,792 Avg Close $92.72 Range $71.14 - $110.75

Q3 2015

Shares 146,500 Value ($000) $11,773 Avg Close $111.10 Range $76.46 - $137.89

Q2 2015

Shares 146,000 Value ($000) $17,501 Avg Close $119.50 Range $98.63 - $140.00

Q1 2015

Shares 98,952 Value ($000) $9,450 Avg Close $101.34 Range $82.06 - $121.93

Q4 2014

Shares 98,952 Value ($000) $9,450 Avg Close $92.65 Range $72.80 - $111.49

Q3 2014

Shares 85,376 Value ($000) $6,668 Avg Close $64.51 Range $51.93 - $79.88

Q2 2014

Shares 125,116 Value ($000) $7,904 Avg Close $59.44 Range $47.03 - $71.40

Q1 2014

Shares 119,911 Value ($000) $7,490 Avg Close $77.42 Range $60.24 - $112.57

Q4 2013

Shares 87,380 Value ($000) $5,847 Avg Close $59.65 Range $48.16 - $67.97

Q3 2013

Shares 86,662 Value ($000) $5,547 Avg Close $49.85 Range $31.75 - $65.83

Q2 2013

Shares 66,462 Value ($000) $2,061 Avg Close $26.61 Range $21.60 - $31.79

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	237,005	$94,245	$442.56	$387.03 - $495.55
Q3 2025	229,641	$104,716	$407.20	$309.57 - $484.21
Q2 2025	211,581	$68,994	$276.71	$205.87 - $327.21
Q1 2025	201,481	$54,404	$257.00	$230.79 - $300.90
Q4 2024	204,132	$48,034	$262.99	$229.86 - $304.39
Q3 2024	211,781	$58,246	$260.36	$231.01 - $287.55
Q2 2024	215,567	$52,383	$157.87	$141.98 - $252.87
Q1 2024	214,330	$32,032	$166.82	$143.52 - $199.38
Q4 2023	179,330	$34,326	$170.34	$148.10 - $198.00
Q3 2023	227,830	$40,349	$191.12	$168.65 - $218.88
Q2 2023	226,279	$42,979	$198.26	$183.00 - $212.47
Q1 2023	237,113	$47,498	$210.20	$179.19 - $242.39
Q4 2022	270,883	$64,375	$213.29	$181.65 - $242.97
Q3 2022	269,760	$53,995	$190.74	$135.46 - $236.80
Q2 2022	236,555	$34,502	$141.87	$117.58 - $180.35
Q1 2022	245,603	$40,105	$152.35	$125.00 - $174.66
Q4 2021	309,675	$52,515	$185.86	$154.82 - $212.00
Q3 2021	318,959	$60,223	$187.58	$166.16 - $209.73
Q2 2021	317,692	$53,855	$146.46	$125.08 - $177.53
Q1 2021	320,047	$45,187	$150.49	$124.00 - $178.41
Q4 2020	333,740	$43,376	$133.53	$119.29 - $148.76
Q3 2020	264,351	$38,490	$142.10	$119.67 - $167.33
Q2 2020	255,768	$37,882	$134.81	$98.01 - $158.37
Q1 2020	220,800	$24,034	$115.43	$84.97 - $134.51
Q4 2019	224,300	$25,833	$99.70	$73.32 - $125.72
Q3 2019	177,600	$14,283	$79.11	$69.11 - $88.00
Q2 2019	121,400	$8,809	$76.72	$65.81 - $96.08
Q1 2019	177,786	$16,614	$83.64	$70.29 - $93.95
Q4 2018	184,959	$13,485	$76.92	$60.27 - $90.00
Q3 2018	182,535	$15,975	$100.59	$86.95 - $124.22
Q2 2018	208,514	$20,537	$99.19	$87.35 - $118.71
Q1 2018	218,599	$26,035	$128.92	$108.13 - $153.99
Q4 2017	196,038	$24,907	$125.65	$111.25 - $147.63
Q3 2017	133,206	$15,650	$85.36	$70.76 - $119.02
Q2 2017	126,700	$10,106	$63.91	$46.90 - $86.92
Q1 2017	110,800	$5,679	$46.22	$35.98 - $60.41
Q4 2016	115,600	$4,328	$41.87	$31.38 - $71.67
Q3 2016	115,600	$7,835	$70.55	$53.56 - $80.11
Q2 2016	123,600	$6,859	$63.00	$49.96 - $75.08
Q1 2016	127,500	$8,003	$66.49	$51.51 - $98.00
Q4 2015	146,500	$13,792	$92.72	$71.14 - $110.75
Q3 2015	146,500	$11,773	$111.10	$76.46 - $137.89
Q2 2015	146,000	$17,501	$119.50	$98.63 - $140.00
Q1 2015	98,952	$9,450	$101.34	$82.06 - $121.93
Q4 2014	98,952	$9,450	$92.65	$72.80 - $111.49
Q3 2014	85,376	$6,668	$64.51	$51.93 - $79.88
Q2 2014	125,116	$7,904	$59.44	$47.03 - $71.40
Q1 2014	119,911	$7,490	$77.42	$60.24 - $112.57
Q4 2013	87,380	$5,847	$59.65	$48.16 - $67.97
Q3 2013	86,662	$5,547	$49.85	$31.75 - $65.83
Q2 2013	66,462	$2,061	$26.61	$21.60 - $31.79