ALNYLAM PHARMACEUTICALS INC

Ticker: ALNY CUSIP: 02043Q107 Class: EQTY

LORING WOLCOTT & COOLIDGE FIDUCIARY ADVISORS LLP/MA's Holding History (CIK: 0000932974)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 1,533 Value ($000) $544 Avg Close $442.56 Range $387.03 - $495.55

Q3 2025

Shares 1,533 Value ($000) $711 Avg Close $407.20 Range $309.57 - $484.21

Q2 2025

Shares 1,533 Value ($000) $500 Avg Close $276.71 Range $205.87 - $327.21

Q1 2025

Shares 1,533 Value ($000) $371 Avg Close $257.00 Range $230.79 - $300.90

Q4 2024

Shares 1,533 Value ($000) $424 Avg Close $262.99 Range $229.86 - $304.39

Q3 2024

Shares 1,790 Value ($000) $526 Avg Close $260.36 Range $231.01 - $287.55

Q2 2024

Shares 1,905 Value ($000) $476 Avg Close $157.87 Range $141.98 - $252.87

Q1 2024

Shares 1,905 Value ($000) $278 Avg Close $166.82 Range $143.52 - $199.38

Q4 2023

Shares 1,905 Value ($000) $329 Avg Close $170.34 Range $148.10 - $198.00

Q3 2023

Shares 1,905 Value ($000) $308 Avg Close $191.12 Range $168.65 - $218.88

Q2 2023

Shares 1,965 Value ($000) $373 Avg Close $198.26 Range $183.00 - $212.47

Q1 2023

Shares 1,965 Value ($000) $394 Avg Close $210.20 Range $179.19 - $242.39

Q4 2022

Shares 1,965 Value ($000) $467 Avg Close $213.29 Range $181.65 - $242.97

Q3 2022

Shares 1,965 Value ($000) $393 Avg Close $190.74 Range $135.46 - $236.80

Q2 2022

Shares 1,965 Value ($000) $287 Avg Close $141.87 Range $117.58 - $180.35

Q1 2022

Shares 2,025 Value ($000) $331 Avg Close $152.35 Range $125.00 - $174.66

Q4 2021

Shares 2,025 Value ($000) $343 Avg Close $185.86 Range $154.82 - $212.00

Q3 2021

Shares 2,025 Value ($000) $382 Avg Close $187.58 Range $166.16 - $209.73

Q2 2021

Shares 2,042 Value ($000) $346 Avg Close $146.46 Range $125.08 - $177.53

Q1 2021

Shares 2,047 Value ($000) $289 Avg Close $150.49 Range $124.00 - $178.41

Q4 2020

Shares 2,025 Value ($000) $263 Avg Close $133.53 Range $119.29 - $148.76

Q3 2020

Shares 2,025 Value ($000) $295 Avg Close $142.10 Range $119.67 - $167.33

Q2 2020

Shares 2,025 Value ($000) $300 Avg Close $134.81 Range $98.01 - $158.37

Q1 2020

Shares 2,025 Value ($000) $220 Avg Close $115.43 Range $84.97 - $134.51

Q4 2019

Shares 2,025 Value ($000) $233 Avg Close $99.70 Range $73.32 - $125.72

Q3 2019

Shares 2,025 Value ($000) $163 Avg Close $79.11 Range $69.11 - $88.00

Q2 2019

Shares 2,025 Value ($000) $147 Avg Close $76.72 Range $65.81 - $96.08

Q1 2019

Shares 2,025 Value ($000) $189 Avg Close $83.64 Range $70.29 - $93.95

Q4 2018

Shares 2,025 Value ($000) $148 Avg Close $76.92 Range $60.27 - $90.00

Q3 2018

Shares 8,030 Value ($000) $703 Avg Close $100.59 Range $86.95 - $124.22

Q2 2018

Shares 8,030 Value ($000) $791 Avg Close $99.19 Range $87.35 - $118.71

Q1 2018

Shares 8,030 Value ($000) $956 Avg Close $128.92 Range $108.13 - $153.99

Q4 2017

Shares 8,030 Value ($000) $1,020 Avg Close $125.65 Range $111.25 - $147.63

Q3 2017

Shares 8,275 Value ($000) $972 Avg Close $85.36 Range $70.76 - $119.02

Q2 2017

Shares 8,275 Value ($000) $685 Avg Close $63.91 Range $46.90 - $86.92

Q1 2017

Shares 8,275 Value ($000) $424 Avg Close $46.22 Range $35.98 - $60.41

Q4 2016

Shares 8,275 Value ($000) $310 Avg Close $41.87 Range $31.38 - $71.67

Q3 2016

Shares 8,275 Value ($000) $561 Avg Close $70.55 Range $53.56 - $80.11

Q2 2016

Shares 8,590 Value ($000) $477 Avg Close $63.00 Range $49.96 - $75.08

Q1 2016

Shares 8,590 Value ($000) $539 Avg Close $66.49 Range $51.51 - $98.00

Q4 2015

Shares 8,590 Value ($000) $809 Avg Close $92.72 Range $71.14 - $110.75

Q3 2015

Shares 12,805 Value ($000) $1,535 Avg Close $111.10 Range $76.46 - $137.89

Q2 2015

Shares 12,805 Value ($000) $1,535 Avg Close $119.50 Range $98.63 - $140.00

Q1 2015

Shares 15,110 Value ($000) $1,578 Avg Close $101.34 Range $82.06 - $121.93

Q4 2014

Shares 16,165 Value ($000) $1,568 Avg Close $92.65 Range $72.80 - $111.49

Q3 2014

Shares 16,165 Value ($000) $1,262 Avg Close $64.51 Range $51.93 - $79.88

Q2 2014

Shares 16,165 Value ($000) $1,021 Avg Close $59.44 Range $47.03 - $71.40

Q1 2014

Shares 16,315 Value ($000) $1,095 Avg Close $77.42 Range $60.24 - $112.57

Q4 2013

Shares 17,975 Value ($000) $1,156 Avg Close $59.65 Range $48.16 - $67.97

Q3 2013

Shares 21,350 Value ($000) $1,367 Avg Close $49.85 Range $31.75 - $65.83

Q2 2013

Shares 23,275 Value ($000) $722 Avg Close $26.61 Range $21.60 - $31.79

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	1,533	$544	$442.56	$387.03 - $495.55
Q3 2025	1,533	$711	$407.20	$309.57 - $484.21
Q2 2025	1,533	$500	$276.71	$205.87 - $327.21
Q1 2025	1,533	$371	$257.00	$230.79 - $300.90
Q4 2024	1,533	$424	$262.99	$229.86 - $304.39
Q3 2024	1,790	$526	$260.36	$231.01 - $287.55
Q2 2024	1,905	$476	$157.87	$141.98 - $252.87
Q1 2024	1,905	$278	$166.82	$143.52 - $199.38
Q4 2023	1,905	$329	$170.34	$148.10 - $198.00
Q3 2023	1,905	$308	$191.12	$168.65 - $218.88
Q2 2023	1,965	$373	$198.26	$183.00 - $212.47
Q1 2023	1,965	$394	$210.20	$179.19 - $242.39
Q4 2022	1,965	$467	$213.29	$181.65 - $242.97
Q3 2022	1,965	$393	$190.74	$135.46 - $236.80
Q2 2022	1,965	$287	$141.87	$117.58 - $180.35
Q1 2022	2,025	$331	$152.35	$125.00 - $174.66
Q4 2021	2,025	$343	$185.86	$154.82 - $212.00
Q3 2021	2,025	$382	$187.58	$166.16 - $209.73
Q2 2021	2,042	$346	$146.46	$125.08 - $177.53
Q1 2021	2,047	$289	$150.49	$124.00 - $178.41
Q4 2020	2,025	$263	$133.53	$119.29 - $148.76
Q3 2020	2,025	$295	$142.10	$119.67 - $167.33
Q2 2020	2,025	$300	$134.81	$98.01 - $158.37
Q1 2020	2,025	$220	$115.43	$84.97 - $134.51
Q4 2019	2,025	$233	$99.70	$73.32 - $125.72
Q3 2019	2,025	$163	$79.11	$69.11 - $88.00
Q2 2019	2,025	$147	$76.72	$65.81 - $96.08
Q1 2019	2,025	$189	$83.64	$70.29 - $93.95
Q4 2018	2,025	$148	$76.92	$60.27 - $90.00
Q3 2018	8,030	$703	$100.59	$86.95 - $124.22
Q2 2018	8,030	$791	$99.19	$87.35 - $118.71
Q1 2018	8,030	$956	$128.92	$108.13 - $153.99
Q4 2017	8,030	$1,020	$125.65	$111.25 - $147.63
Q3 2017	8,275	$972	$85.36	$70.76 - $119.02
Q2 2017	8,275	$685	$63.91	$46.90 - $86.92
Q1 2017	8,275	$424	$46.22	$35.98 - $60.41
Q4 2016	8,275	$310	$41.87	$31.38 - $71.67
Q3 2016	8,275	$561	$70.55	$53.56 - $80.11
Q2 2016	8,590	$477	$63.00	$49.96 - $75.08
Q1 2016	8,590	$539	$66.49	$51.51 - $98.00
Q4 2015	8,590	$809	$92.72	$71.14 - $110.75
Q3 2015	12,805	$1,535	$111.10	$76.46 - $137.89
Q2 2015	12,805	$1,535	$119.50	$98.63 - $140.00
Q1 2015	15,110	$1,578	$101.34	$82.06 - $121.93
Q4 2014	16,165	$1,568	$92.65	$72.80 - $111.49
Q3 2014	16,165	$1,262	$64.51	$51.93 - $79.88
Q2 2014	16,165	$1,021	$59.44	$47.03 - $71.40
Q1 2014	16,315	$1,095	$77.42	$60.24 - $112.57
Q4 2013	17,975	$1,156	$59.65	$48.16 - $67.97
Q3 2013	21,350	$1,367	$49.85	$31.75 - $65.83
Q2 2013	23,275	$722	$26.61	$21.60 - $31.79