ALNYLAM PHARMACEUTICALS INC

Ticker: ALNY CUSIP: 02043Q107 Class: EQTY

D. E. Shaw & Co., Inc.'s Holding History (CIK: 0001009207)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 444,493 Value ($000) $176,753 Avg Close $442.56 Range $387.03 - $495.55

Q3 2025

Shares 199,417 Value ($000) $90,934 Avg Close $407.20 Range $309.57 - $484.21

Q2 2025

Shares 108,276 Value ($000) $35,308 Avg Close $276.71 Range $205.87 - $327.21

Q1 2025

Shares 289,862 Value ($000) $78,269 Avg Close $257.00 Range $230.79 - $300.90

Q4 2024

Shares 363,085 Value ($000) $85,438 Avg Close $262.99 Range $229.86 - $304.39

Q3 2024

Shares 332,305 Value ($000) $91,394 Avg Close $260.36 Range $231.01 - $287.55

Q2 2024

Shares 279,398 Value ($000) $67,894 Avg Close $157.87 Range $141.98 - $252.87

Q1 2024

Shares 103,387 Value ($000) $15,451 Avg Close $166.82 Range $143.52 - $199.38

Q4 2023

Shares 95,544 Value ($000) $18,288 Avg Close $170.34 Range $148.10 - $198.00

Q3 2023

Shares 204,092 Value ($000) $36,145 Avg Close $191.12 Range $168.65 - $218.88

Q2 2023

Shares 248,272 Value ($000) $47,157 Avg Close $198.26 Range $183.00 - $212.47

Q1 2023

Shares 231,345 Value ($000) $46,343 Avg Close $210.20 Range $179.19 - $242.39

Q4 2022

Shares 176,416 Value ($000) $41,925 Avg Close $213.29 Range $181.65 - $242.97

Q3 2022

Shares 151,144 Value ($000) $30,253 Avg Close $190.74 Range $135.46 - $236.80

Q2 2022

Shares 135,923 Value ($000) $19,824 Avg Close $141.87 Range $117.58 - $180.35

Q1 2022

Shares 14,883 Value ($000) $2,430 Avg Close $152.35 Range $125.00 - $174.66

Q4 2021

Shares 46,340 Value ($000) $7,858 Avg Close $185.86 Range $154.82 - $212.00

Q3 2021

Shares 33,063 Value ($000) $6,243 Avg Close $187.58 Range $166.16 - $209.73

Q2 2021

Shares 36,408 Value ($000) $6,172 Avg Close $146.46 Range $125.08 - $177.53

Q1 2021

Shares 77,903 Value ($000) $10,999 Avg Close $150.49 Range $124.00 - $178.41

Q4 2020

Shares 64,501 Value ($000) $8,383 Avg Close $133.53 Range $119.29 - $148.76

Q3 2020

Shares 170,238 Value ($000) $24,787 Avg Close $142.10 Range $119.67 - $167.33

Q2 2020

Shares 113,887 Value ($000) $16,868 Avg Close $134.81 Range $98.01 - $158.37

Q1 2020

Shares 230,553 Value ($000) $25,096 Avg Close $115.43 Range $84.97 - $134.51

Q4 2019

Shares 18,628 Value ($000) $2,145 Avg Close $99.70 Range $73.32 - $125.72

Q3 2019

Shares 26,797 Value ($000) $2,155 Avg Close $79.11 Range $69.11 - $88.00

Q2 2019

Shares 13,757 Value ($000) $998 Avg Close $76.72 Range $65.81 - $96.08

Q1 2019

Shares 11,214 Value ($000) $1,048 Avg Close $83.64 Range $70.29 - $93.95

Q4 2018

Shares 36,818 Value ($000) $2,684 Avg Close $76.92 Range $60.27 - $90.00

Q3 2018

Shares 8,738 Value ($000) $765 Avg Close $100.59 Range $86.95 - $124.22

Q2 2018

Shares 83,611 Value ($000) $8,235 Avg Close $99.19 Range $87.35 - $118.71

Q1 2018

Shares 271,061 Value ($000) $32,283 Avg Close $128.92 Range $108.13 - $153.99

Q4 2017

Shares 272,720 Value ($000) $34,649 Avg Close $125.65 Range $111.25 - $147.63

Q3 2017

Shares 982,454 Value ($000) $115,429 Avg Close $85.36 Range $70.76 - $119.02

Q2 2017

Shares 733,650 Value ($000) $58,516 Avg Close $63.91 Range $46.90 - $86.92

Q1 2017

Shares 495,394 Value ($000) $25,389 Avg Close $46.22 Range $35.98 - $60.41

Q4 2016

Shares 215,426 Value ($000) $8,065 Avg Close $41.87 Range $31.38 - $71.67

Q3 2016

Shares 25,122 Value ($000) $1,703 Avg Close $70.55 Range $53.56 - $80.11

Q2 2016

Shares 39,752 Value ($000) $2,206 Avg Close $63.00 Range $49.96 - $75.08

Q1 2016

Shares 195,044 Value ($000) $12,243 Avg Close $66.49 Range $51.51 - $98.00

Q4 2015

Shares 81,112 Value ($000) $7,636 Avg Close $92.72 Range $71.14 - $110.75

Q3 2015

Shares 37,513 Value ($000) $3,015 Avg Close $111.10 Range $76.46 - $137.89

Q2 2015

Shares 204,027 Value ($000) $24,457 Avg Close $119.50 Range $98.63 - $140.00

Q1 2015

Shares 267,612 Value ($000) $27,944 Avg Close $101.34 Range $82.06 - $121.93

Q4 2014

Shares 191,259 Value ($000) $18,552 Avg Close $92.65 Range $72.80 - $111.49

Q3 2014

Shares 14,143 Value ($000) $1,105 Avg Close $64.51 Range $51.93 - $79.88

Q2 2014

Shares 6,421 Value ($000) $406 Avg Close $59.44 Range $47.03 - $71.40

Q1 2014

Shares 75,133 Value ($000) $5,044 Avg Close $77.42 Range $60.24 - $112.57

Q4 2013

Shares 6,900 Value ($000) $444 Avg Close $59.65 Range $48.16 - $67.97

Q3 2013

Shares 3,299 Value ($000) $211 Avg Close $49.85 Range $31.75 - $65.83

Q2 2013

Shares 219,088 Value ($000) $6,794 Avg Close $26.61 Range $21.60 - $31.79

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	444,493	$176,753	$442.56	$387.03 - $495.55
Q3 2025	199,417	$90,934	$407.20	$309.57 - $484.21
Q2 2025	108,276	$35,308	$276.71	$205.87 - $327.21
Q1 2025	289,862	$78,269	$257.00	$230.79 - $300.90
Q4 2024	363,085	$85,438	$262.99	$229.86 - $304.39
Q3 2024	332,305	$91,394	$260.36	$231.01 - $287.55
Q2 2024	279,398	$67,894	$157.87	$141.98 - $252.87
Q1 2024	103,387	$15,451	$166.82	$143.52 - $199.38
Q4 2023	95,544	$18,288	$170.34	$148.10 - $198.00
Q3 2023	204,092	$36,145	$191.12	$168.65 - $218.88
Q2 2023	248,272	$47,157	$198.26	$183.00 - $212.47
Q1 2023	231,345	$46,343	$210.20	$179.19 - $242.39
Q4 2022	176,416	$41,925	$213.29	$181.65 - $242.97
Q3 2022	151,144	$30,253	$190.74	$135.46 - $236.80
Q2 2022	135,923	$19,824	$141.87	$117.58 - $180.35
Q1 2022	14,883	$2,430	$152.35	$125.00 - $174.66
Q4 2021	46,340	$7,858	$185.86	$154.82 - $212.00
Q3 2021	33,063	$6,243	$187.58	$166.16 - $209.73
Q2 2021	36,408	$6,172	$146.46	$125.08 - $177.53
Q1 2021	77,903	$10,999	$150.49	$124.00 - $178.41
Q4 2020	64,501	$8,383	$133.53	$119.29 - $148.76
Q3 2020	170,238	$24,787	$142.10	$119.67 - $167.33
Q2 2020	113,887	$16,868	$134.81	$98.01 - $158.37
Q1 2020	230,553	$25,096	$115.43	$84.97 - $134.51
Q4 2019	18,628	$2,145	$99.70	$73.32 - $125.72
Q3 2019	26,797	$2,155	$79.11	$69.11 - $88.00
Q2 2019	13,757	$998	$76.72	$65.81 - $96.08
Q1 2019	11,214	$1,048	$83.64	$70.29 - $93.95
Q4 2018	36,818	$2,684	$76.92	$60.27 - $90.00
Q3 2018	8,738	$765	$100.59	$86.95 - $124.22
Q2 2018	83,611	$8,235	$99.19	$87.35 - $118.71
Q1 2018	271,061	$32,283	$128.92	$108.13 - $153.99
Q4 2017	272,720	$34,649	$125.65	$111.25 - $147.63
Q3 2017	982,454	$115,429	$85.36	$70.76 - $119.02
Q2 2017	733,650	$58,516	$63.91	$46.90 - $86.92
Q1 2017	495,394	$25,389	$46.22	$35.98 - $60.41
Q4 2016	215,426	$8,065	$41.87	$31.38 - $71.67
Q3 2016	25,122	$1,703	$70.55	$53.56 - $80.11
Q2 2016	39,752	$2,206	$63.00	$49.96 - $75.08
Q1 2016	195,044	$12,243	$66.49	$51.51 - $98.00
Q4 2015	81,112	$7,636	$92.72	$71.14 - $110.75
Q3 2015	37,513	$3,015	$111.10	$76.46 - $137.89
Q2 2015	204,027	$24,457	$119.50	$98.63 - $140.00
Q1 2015	267,612	$27,944	$101.34	$82.06 - $121.93
Q4 2014	191,259	$18,552	$92.65	$72.80 - $111.49
Q3 2014	14,143	$1,105	$64.51	$51.93 - $79.88
Q2 2014	6,421	$406	$59.44	$47.03 - $71.40
Q1 2014	75,133	$5,044	$77.42	$60.24 - $112.57
Q4 2013	6,900	$444	$59.65	$48.16 - $67.97
Q3 2013	3,299	$211	$49.85	$31.75 - $65.83
Q2 2013	219,088	$6,794	$26.61	$21.60 - $31.79