ALNYLAM PHARMACEUTICALS INC

Ticker: ALNY CUSIP: 02043Q107 Class: EQTY

PROFUND ADVISORS LLC's Holding History (CIK: 0001129919)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 15,589 Value ($000) $6,199 Avg Close $442.56 Range $387.03 - $495.55

Q3 2025

Shares 3,536 Value ($000) $1,612 Avg Close $407.20 Range $309.57 - $484.21

Q2 2025

Shares 6,418 Value ($000) $2,093 Avg Close $276.71 Range $205.87 - $327.21

Q1 2025

Shares 8,826 Value ($000) $2,383 Avg Close $257.00 Range $230.79 - $300.90

Q4 2024

Shares 9,695 Value ($000) $2,281 Avg Close $262.99 Range $229.86 - $304.39

Q3 2024

Shares 12,074 Value ($000) $3,321 Avg Close $260.36 Range $231.01 - $287.55

Q2 2024

Shares 14,402 Value ($000) $3,500 Avg Close $157.87 Range $141.98 - $252.87

Q1 2024

Shares 9,270 Value ($000) $1,385 Avg Close $166.82 Range $143.52 - $199.38

Q4 2023

Shares 8,332 Value ($000) $1,595 Avg Close $170.34 Range $148.10 - $198.00

Q3 2023

Shares 7,257 Value ($000) $1,285 Avg Close $191.12 Range $168.65 - $218.88

Q2 2023

Shares 7,729 Value ($000) $1,468 Avg Close $198.26 Range $183.00 - $212.47

Q1 2023

Shares 6,770 Value ($000) $1,356 Avg Close $210.20 Range $179.19 - $242.39

Q4 2022

Shares 13,724 Value ($000) $3,262 Avg Close $213.29 Range $181.65 - $242.97

Q3 2022

Shares 13,088 Value ($000) $2,620 Avg Close $190.74 Range $135.46 - $236.80

Q2 2022

Shares 13,805 Value ($000) $2,013 Avg Close $141.87 Range $117.58 - $180.35

Q1 2022

Shares 14,975 Value ($000) $2,445 Avg Close $152.35 Range $125.00 - $174.66

Q4 2021

Shares 16,446 Value ($000) $2,789 Avg Close $185.86 Range $154.82 - $212.00

Q3 2021

Shares 19,272 Value ($000) $3,639 Avg Close $187.58 Range $166.16 - $209.73

Q2 2021

Shares 20,061 Value ($000) $3,400 Avg Close $146.46 Range $125.08 - $177.53

Q1 2021

Shares 20,613 Value ($000) $2,910 Avg Close $150.49 Range $124.00 - $178.41

Q4 2020

Shares 23,673 Value ($000) $3,077 Avg Close $133.53 Range $119.29 - $148.76

Q3 2020

Shares 21,556 Value ($000) $3,139 Avg Close $142.10 Range $119.67 - $167.33

Q2 2020

Shares 25,057 Value ($000) $3,711 Avg Close $134.81 Range $98.01 - $158.37

Q1 2020

Shares 20,946 Value ($000) $2,280 Avg Close $115.43 Range $84.97 - $134.51

Q4 2019

Shares 28,589 Value ($000) $3,293 Avg Close $99.70 Range $73.32 - $125.72

Q3 2019

Shares 25,593 Value ($000) $2,058 Avg Close $79.11 Range $69.11 - $88.00

Q2 2019

Shares 23,357 Value ($000) $1,695 Avg Close $76.72 Range $65.81 - $96.08

Q1 2019

Shares 26,349 Value ($000) $2,462 Avg Close $83.64 Range $70.29 - $93.95

Q4 2018

Shares 24,694 Value ($000) $1,800 Avg Close $76.92 Range $60.27 - $90.00

Q3 2018

Shares 30,620 Value ($000) $2,680 Avg Close $100.59 Range $86.95 - $124.22

Q2 2018

Shares 25,949 Value ($000) $2,556 Avg Close $99.19 Range $87.35 - $118.71

Q1 2018

Shares 27,101 Value ($000) $3,228 Avg Close $128.92 Range $108.13 - $153.99

Q4 2017

Shares 29,947 Value ($000) $3,805 Avg Close $125.65 Range $111.25 - $147.63

Q3 2017

Shares 31,449 Value ($000) $3,695 Avg Close $85.36 Range $70.76 - $119.02

Q2 2017

Shares 30,912 Value ($000) $2,466 Avg Close $63.91 Range $46.90 - $86.92

Q1 2017

Shares 29,138 Value ($000) $1,493 Avg Close $46.22 Range $35.98 - $60.41

Q4 2016

Shares 31,480 Value ($000) $1,179 Avg Close $41.87 Range $31.38 - $71.67

Q3 2016

Shares 36,464 Value ($000) $2,472 Avg Close $70.55 Range $53.56 - $80.11

Q2 2016

Shares 40,104 Value ($000) $2,225 Avg Close $63.00 Range $49.96 - $75.08

Q1 2016

Shares 41,812 Value ($000) $2,625 Avg Close $66.49 Range $51.51 - $98.00

Q4 2015

Shares 51,734 Value ($000) $4,870 Avg Close $92.72 Range $71.14 - $110.75

Q3 2015

Shares 51,839 Value ($000) $4,166 Avg Close $111.10 Range $76.46 - $137.89

Q2 2015

Shares 54,761 Value ($000) $6,564 Avg Close $119.50 Range $98.63 - $140.00

Q1 2015

Shares 54,863 Value ($000) $5,729 Avg Close $101.34 Range $82.06 - $121.93

Q4 2014

Shares 46,640 Value ($000) $4,524 Avg Close $92.65 Range $72.80 - $111.49

Q3 2014

Shares 41,636 Value ($000) $3,252 Avg Close $64.51 Range $51.93 - $79.88

Q2 2014

Shares 37,960 Value ($000) $2,398 Avg Close $59.44 Range $47.03 - $71.40

Q1 2014

Shares 44,610 Value ($000) $2,995 Avg Close $77.42 Range $60.24 - $112.57

Q4 2013

Shares 35,279 Value ($000) $2,269 Avg Close $59.65 Range $48.16 - $67.97

Q3 2013

Shares 27,552 Value ($000) $1,764 Avg Close $49.85 Range $31.75 - $65.83

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	15,589	$6,199	$442.56	$387.03 - $495.55
Q3 2025	3,536	$1,612	$407.20	$309.57 - $484.21
Q2 2025	6,418	$2,093	$276.71	$205.87 - $327.21
Q1 2025	8,826	$2,383	$257.00	$230.79 - $300.90
Q4 2024	9,695	$2,281	$262.99	$229.86 - $304.39
Q3 2024	12,074	$3,321	$260.36	$231.01 - $287.55
Q2 2024	14,402	$3,500	$157.87	$141.98 - $252.87
Q1 2024	9,270	$1,385	$166.82	$143.52 - $199.38
Q4 2023	8,332	$1,595	$170.34	$148.10 - $198.00
Q3 2023	7,257	$1,285	$191.12	$168.65 - $218.88
Q2 2023	7,729	$1,468	$198.26	$183.00 - $212.47
Q1 2023	6,770	$1,356	$210.20	$179.19 - $242.39
Q4 2022	13,724	$3,262	$213.29	$181.65 - $242.97
Q3 2022	13,088	$2,620	$190.74	$135.46 - $236.80
Q2 2022	13,805	$2,013	$141.87	$117.58 - $180.35
Q1 2022	14,975	$2,445	$152.35	$125.00 - $174.66
Q4 2021	16,446	$2,789	$185.86	$154.82 - $212.00
Q3 2021	19,272	$3,639	$187.58	$166.16 - $209.73
Q2 2021	20,061	$3,400	$146.46	$125.08 - $177.53
Q1 2021	20,613	$2,910	$150.49	$124.00 - $178.41
Q4 2020	23,673	$3,077	$133.53	$119.29 - $148.76
Q3 2020	21,556	$3,139	$142.10	$119.67 - $167.33
Q2 2020	25,057	$3,711	$134.81	$98.01 - $158.37
Q1 2020	20,946	$2,280	$115.43	$84.97 - $134.51
Q4 2019	28,589	$3,293	$99.70	$73.32 - $125.72
Q3 2019	25,593	$2,058	$79.11	$69.11 - $88.00
Q2 2019	23,357	$1,695	$76.72	$65.81 - $96.08
Q1 2019	26,349	$2,462	$83.64	$70.29 - $93.95
Q4 2018	24,694	$1,800	$76.92	$60.27 - $90.00
Q3 2018	30,620	$2,680	$100.59	$86.95 - $124.22
Q2 2018	25,949	$2,556	$99.19	$87.35 - $118.71
Q1 2018	27,101	$3,228	$128.92	$108.13 - $153.99
Q4 2017	29,947	$3,805	$125.65	$111.25 - $147.63
Q3 2017	31,449	$3,695	$85.36	$70.76 - $119.02
Q2 2017	30,912	$2,466	$63.91	$46.90 - $86.92
Q1 2017	29,138	$1,493	$46.22	$35.98 - $60.41
Q4 2016	31,480	$1,179	$41.87	$31.38 - $71.67
Q3 2016	36,464	$2,472	$70.55	$53.56 - $80.11
Q2 2016	40,104	$2,225	$63.00	$49.96 - $75.08
Q1 2016	41,812	$2,625	$66.49	$51.51 - $98.00
Q4 2015	51,734	$4,870	$92.72	$71.14 - $110.75
Q3 2015	51,839	$4,166	$111.10	$76.46 - $137.89
Q2 2015	54,761	$6,564	$119.50	$98.63 - $140.00
Q1 2015	54,863	$5,729	$101.34	$82.06 - $121.93
Q4 2014	46,640	$4,524	$92.65	$72.80 - $111.49
Q3 2014	41,636	$3,252	$64.51	$51.93 - $79.88
Q2 2014	37,960	$2,398	$59.44	$47.03 - $71.40
Q1 2014	44,610	$2,995	$77.42	$60.24 - $112.57
Q4 2013	35,279	$2,269	$59.65	$48.16 - $67.97
Q3 2013	27,552	$1,764	$49.85	$31.75 - $65.83