ALNYLAM PHARMACEUTICALS INC

Ticker: ALNY CUSIP: 02043Q107 Class: EQTY

BRANDYWINE MANAGERS, LLC's Holding History (CIK: 0001135121)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 3,618 Value ($000) $1,439 Avg Close $442.56 Range $387.03 - $495.55

Q3 2025

Shares 3,718 Value ($000) $1,695 Avg Close $407.20 Range $309.57 - $484.21

Q2 2025

Shares 4,218 Value ($000) $1,375 Avg Close $276.71 Range $205.87 - $327.21

Q1 2025

Shares 4,348 Value ($000) $1,174 Avg Close $257.00 Range $230.79 - $300.90

Q4 2024

Shares 4,348 Value ($000) $1,023 Avg Close $262.99 Range $229.86 - $304.39

Q3 2024

Shares 4,348 Value ($000) $1,196 Avg Close $260.36 Range $231.01 - $287.55

Q2 2024

Shares 4,348 Value ($000) $1,057 Avg Close $157.87 Range $141.98 - $252.87

Q1 2024

Shares 4,348 Value ($000) $650 Avg Close $166.82 Range $143.52 - $199.38

Q4 2023

Shares 4,348 Value ($000) $832 Avg Close $170.34 Range $148.10 - $198.00

Q3 2023

Shares 4,608 Value ($000) $816 Avg Close $191.12 Range $168.65 - $218.88

Q2 2023

Shares 4,608 Value ($000) $875 Avg Close $198.26 Range $183.00 - $212.47

Q1 2023

Shares 4,608 Value ($000) $923 Avg Close $210.20 Range $179.19 - $242.39

Q4 2022

Shares 4,608 Value ($000) $1,095 Avg Close $213.29 Range $181.65 - $242.97

Q3 2022

Shares 4,608 Value ($000) $922 Avg Close $190.74 Range $135.46 - $236.80

Q2 2022

Shares 4,608 Value ($000) $672 Avg Close $141.87 Range $117.58 - $180.35

Q1 2022

Shares 4,608 Value ($000) $752 Avg Close $152.35 Range $125.00 - $174.66

Q4 2021

Shares 4,608 Value ($000) $781 Avg Close $185.86 Range $154.82 - $212.00

Q3 2021

Shares 4,608 Value ($000) $870 Avg Close $187.58 Range $166.16 - $209.73

Q2 2021

Shares 4,608 Value ($000) $781 Avg Close $146.46 Range $125.08 - $177.53

Q1 2021

Shares 4,608 Value ($000) $651 Avg Close $150.49 Range $124.00 - $178.41

Q4 2020

Shares 2,900 Value ($000) $377 Avg Close $133.53 Range $119.29 - $148.76

Q3 2020

Shares 2,900 Value ($000) $422 Avg Close $142.10 Range $119.67 - $167.33

Q2 2020

Shares 2,900 Value ($000) $430 Avg Close $134.81 Range $98.01 - $158.37

Q1 2020

Shares 2,900 Value ($000) $316 Avg Close $115.43 Range $84.97 - $134.51

Q4 2019

Shares 2,900 Value ($000) $334 Avg Close $99.70 Range $73.32 - $125.72

Q3 2019

Shares 3,100 Value ($000) $249 Avg Close $79.11 Range $69.11 - $88.00

Q2 2019

Shares 3,100 Value ($000) $225 Avg Close $76.72 Range $65.81 - $96.08

Q1 2019

Shares 4,000 Value ($000) $374 Avg Close $83.64 Range $70.29 - $93.95

Q4 2018

Shares 4,200 Value ($000) $306 Avg Close $76.92 Range $60.27 - $90.00

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	3,618	$1,439	$442.56	$387.03 - $495.55
Q3 2025	3,718	$1,695	$407.20	$309.57 - $484.21
Q2 2025	4,218	$1,375	$276.71	$205.87 - $327.21
Q1 2025	4,348	$1,174	$257.00	$230.79 - $300.90
Q4 2024	4,348	$1,023	$262.99	$229.86 - $304.39
Q3 2024	4,348	$1,196	$260.36	$231.01 - $287.55
Q2 2024	4,348	$1,057	$157.87	$141.98 - $252.87
Q1 2024	4,348	$650	$166.82	$143.52 - $199.38
Q4 2023	4,348	$832	$170.34	$148.10 - $198.00
Q3 2023	4,608	$816	$191.12	$168.65 - $218.88
Q2 2023	4,608	$875	$198.26	$183.00 - $212.47
Q1 2023	4,608	$923	$210.20	$179.19 - $242.39
Q4 2022	4,608	$1,095	$213.29	$181.65 - $242.97
Q3 2022	4,608	$922	$190.74	$135.46 - $236.80
Q2 2022	4,608	$672	$141.87	$117.58 - $180.35
Q1 2022	4,608	$752	$152.35	$125.00 - $174.66
Q4 2021	4,608	$781	$185.86	$154.82 - $212.00
Q3 2021	4,608	$870	$187.58	$166.16 - $209.73
Q2 2021	4,608	$781	$146.46	$125.08 - $177.53
Q1 2021	4,608	$651	$150.49	$124.00 - $178.41
Q4 2020	2,900	$377	$133.53	$119.29 - $148.76
Q3 2020	2,900	$422	$142.10	$119.67 - $167.33
Q2 2020	2,900	$430	$134.81	$98.01 - $158.37
Q1 2020	2,900	$316	$115.43	$84.97 - $134.51
Q4 2019	2,900	$334	$99.70	$73.32 - $125.72
Q3 2019	3,100	$249	$79.11	$69.11 - $88.00
Q2 2019	3,100	$225	$76.72	$65.81 - $96.08
Q1 2019	4,000	$374	$83.64	$70.29 - $93.95
Q4 2018	4,200	$306	$76.92	$60.27 - $90.00