ALNYLAM PHARMACEUTICALS INC

Ticker: ALNY CUSIP: 02043Q107 Class: EQTY

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 616,120 Value ($000) $245,000 Avg Close $442.56 Range $387.03 - $495.55

Q3 2025

Shares 595,926 Value ($000) $271,742 Avg Close $407.20 Range $309.57 - $484.21

Q2 2025

Shares 343,305 Value ($000) $111,948 Avg Close $276.71 Range $205.87 - $327.21

Q1 2025

Shares 197,415 Value ($000) $53,306 Avg Close $257.00 Range $230.79 - $300.90

Q4 2024

Shares 107,117 Value ($000) $25,206 Avg Close $262.99 Range $229.86 - $304.39

Q3 2024

Shares 19,148 Value ($000) $5,266 Avg Close $260.36 Range $231.01 - $287.55

Q2 2024

Shares 102,918 Value ($000) $25,009 Avg Close $157.87 Range $141.98 - $252.87

Q1 2024

Shares 102,512 Value ($000) $15,320 Avg Close $166.82 Range $143.52 - $199.38

Q3 2023

Shares 3,300 Value ($000) $584 Avg Close $191.12 Range $168.65 - $218.88

Q2 2023

Shares 224,669 Value ($000) $42,674 Avg Close $198.26 Range $183.00 - $212.47

Q1 2023

Shares 167,346 Value ($000) $33,523 Avg Close $210.20 Range $179.19 - $242.39

Q4 2022

Shares 182,707 Value ($000) $43,420 Avg Close $213.29 Range $181.65 - $242.97

Q3 2022

Shares 216,712 Value ($000) $43,377 Avg Close $190.74 Range $135.46 - $236.80

Q1 2022

Shares 73,949 Value ($000) $12,075 Avg Close $152.35 Range $125.00 - $174.66

Q1 2021

Shares 36,619 Value ($000) $5,170 Avg Close $150.49 Range $124.00 - $178.41

Q3 2018

Shares 20,675 Value ($000) $1,809 Avg Close $100.59 Range $86.95 - $124.22

Q1 2018

Shares 256,376 Value ($000) $30,534 Avg Close $128.92 Range $108.13 - $153.99

Q4 2017

Shares 302,376 Value ($000) $38,417 Avg Close $125.65 Range $111.25 - $147.63

Q3 2017

Shares 143,874 Value ($000) $16,904 Avg Close $85.36 Range $70.76 - $119.02

Q2 2017

Shares 2,747 Value ($000) $219 Avg Close $63.91 Range $46.90 - $86.92

Q1 2016

Shares 84,077 Value ($000) $5,278 Avg Close $66.49 Range $51.51 - $98.00

Q2 2015

Shares 18,630 Value ($000) $2,233 Avg Close $119.50 Range $98.63 - $140.00

Q2 2013

Shares 16,190 Value ($000) $502 Avg Close $26.61 Range $21.60 - $31.79

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	616,120	$245,000	$442.56	$387.03 - $495.55
Q3 2025	595,926	$271,742	$407.20	$309.57 - $484.21
Q2 2025	343,305	$111,948	$276.71	$205.87 - $327.21
Q1 2025	197,415	$53,306	$257.00	$230.79 - $300.90
Q4 2024	107,117	$25,206	$262.99	$229.86 - $304.39
Q3 2024	19,148	$5,266	$260.36	$231.01 - $287.55
Q2 2024	102,918	$25,009	$157.87	$141.98 - $252.87
Q1 2024	102,512	$15,320	$166.82	$143.52 - $199.38
Q3 2023	3,300	$584	$191.12	$168.65 - $218.88
Q2 2023	224,669	$42,674	$198.26	$183.00 - $212.47
Q1 2023	167,346	$33,523	$210.20	$179.19 - $242.39
Q4 2022	182,707	$43,420	$213.29	$181.65 - $242.97
Q3 2022	216,712	$43,377	$190.74	$135.46 - $236.80
Q1 2022	73,949	$12,075	$152.35	$125.00 - $174.66
Q1 2021	36,619	$5,170	$150.49	$124.00 - $178.41
Q3 2018	20,675	$1,809	$100.59	$86.95 - $124.22
Q1 2018	256,376	$30,534	$128.92	$108.13 - $153.99
Q4 2017	302,376	$38,417	$125.65	$111.25 - $147.63
Q3 2017	143,874	$16,904	$85.36	$70.76 - $119.02
Q2 2017	2,747	$219	$63.91	$46.90 - $86.92
Q1 2016	84,077	$5,278	$66.49	$51.51 - $98.00
Q2 2015	18,630	$2,233	$119.50	$98.63 - $140.00
Q2 2013	16,190	$502	$26.61	$21.60 - $31.79