ALNYLAM PHARMACEUTICALS INC

Ticker: ALNY CUSIP: 02043Q107 Class: EQTY

BRITISH COLUMBIA INVESTMENT MANAGEMENT Corp's Holding History (CIK: 0001228242)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 23,220 Value ($000) $9,233 Avg Close $442.56 Range $387.03 - $495.55

Q3 2025

Shares 18,739 Value ($000) $8,545 Avg Close $407.20 Range $309.57 - $484.21

Q2 2025

Shares 20,471 Value ($000) $6,675 Avg Close $276.71 Range $205.87 - $327.21

Q1 2025

Shares 24,666 Value ($000) $6,660 Avg Close $257.00 Range $230.79 - $300.90

Q4 2024

Shares 24,582 Value ($000) $5,784 Avg Close $262.99 Range $229.86 - $304.39

Q3 2024

Shares 21,108 Value ($000) $5,805 Avg Close $260.36 Range $231.01 - $287.55

Q2 2024

Shares 24,217 Value ($000) $5,885 Avg Close $157.87 Range $141.98 - $252.87

Q1 2024

Shares 14,983 Value ($000) $2,239 Avg Close $166.82 Range $143.52 - $199.38

Q4 2023

Shares 14,384 Value ($000) $2,753 Avg Close $170.34 Range $148.10 - $198.00

Q3 2023

Shares 11,321 Value ($000) $2,005 Avg Close $191.12 Range $168.65 - $218.88

Q2 2023

Shares 11,177 Value ($000) $2,123 Avg Close $198.26 Range $183.00 - $212.47

Q1 2023

Shares 10,958 Value ($000) $2,195 Avg Close $210.20 Range $179.19 - $242.39

Q4 2022

Shares 10,634 Value ($000) $2,527 Avg Close $213.29 Range $181.65 - $242.97

Q3 2022

Shares 11,908 Value ($000) $2,384 Avg Close $190.74 Range $135.46 - $236.80

Q2 2022

Shares 13,925 Value ($000) $2,031 Avg Close $141.87 Range $117.58 - $180.35

Q1 2022

Shares 18,462 Value ($000) $3,015 Avg Close $152.35 Range $125.00 - $174.66

Q4 2021

Shares 20,948 Value ($000) $3,552 Avg Close $185.86 Range $154.82 - $212.00

Q3 2021

Shares 21,659 Value ($000) $4,089 Avg Close $187.58 Range $166.16 - $209.73

Q2 2021

Shares 21,662 Value ($000) $3,672 Avg Close $146.46 Range $125.08 - $177.53

Q1 2021

Shares 19,023 Value ($000) $2,686 Avg Close $150.49 Range $124.00 - $178.41

Q4 2020

Shares 19,531 Value ($000) $2,538 Avg Close $133.53 Range $119.29 - $148.76

Q3 2020

Shares 19,913 Value ($000) $2,899 Avg Close $142.10 Range $119.67 - $167.33

Q2 2020

Shares 18,041 Value ($000) $2,672 Avg Close $134.81 Range $98.01 - $158.37

Q1 2020

Shares 12,197 Value ($000) $1,328 Avg Close $115.43 Range $84.97 - $134.51

Q4 2019

Shares 26,204 Value ($000) $3,018 Avg Close $99.70 Range $73.32 - $125.72

Q3 2019

Shares 17,110 Value ($000) $1,376 Avg Close $79.11 Range $69.11 - $88.00

Q2 2019

Shares 22,369 Value ($000) $1,623 Avg Close $76.72 Range $65.81 - $96.08

Q1 2019

Shares 20,716 Value ($000) $1,936 Avg Close $83.64 Range $70.29 - $93.95

Q4 2018

Shares 22,820 Value ($000) $1,664 Avg Close $76.92 Range $60.27 - $90.00

Q3 2018

Shares 19,929 Value ($000) $1,744 Avg Close $100.59 Range $86.95 - $124.22

Q2 2018

Shares 27,025 Value ($000) $2,662 Avg Close $99.19 Range $87.35 - $118.71

Q1 2018

Shares 33,261 Value ($000) $3,961 Avg Close $128.92 Range $108.13 - $153.99

Q4 2017

Shares 34,505 Value ($000) $4,384 Avg Close $125.65 Range $111.25 - $147.63

Q3 2016

Shares 9,678 Value ($000) $656 Avg Close $70.55 Range $53.56 - $80.11

Q2 2016

Shares 14,377 Value ($000) $798 Avg Close $63.00 Range $49.96 - $75.08

Q1 2016

Shares 14,377 Value ($000) $902 Avg Close $66.49 Range $51.51 - $98.00

Q4 2015

Shares 48,030 Value ($000) $4,522 Avg Close $92.72 Range $71.14 - $110.75

Q3 2015

Shares 22,007 Value ($000) $1,768 Avg Close $111.10 Range $76.46 - $137.89

Q2 2015

Shares 16,154 Value ($000) $1,936 Avg Close $119.50 Range $98.63 - $140.00

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	23,220	$9,233	$442.56	$387.03 - $495.55
Q3 2025	18,739	$8,545	$407.20	$309.57 - $484.21
Q2 2025	20,471	$6,675	$276.71	$205.87 - $327.21
Q1 2025	24,666	$6,660	$257.00	$230.79 - $300.90
Q4 2024	24,582	$5,784	$262.99	$229.86 - $304.39
Q3 2024	21,108	$5,805	$260.36	$231.01 - $287.55
Q2 2024	24,217	$5,885	$157.87	$141.98 - $252.87
Q1 2024	14,983	$2,239	$166.82	$143.52 - $199.38
Q4 2023	14,384	$2,753	$170.34	$148.10 - $198.00
Q3 2023	11,321	$2,005	$191.12	$168.65 - $218.88
Q2 2023	11,177	$2,123	$198.26	$183.00 - $212.47
Q1 2023	10,958	$2,195	$210.20	$179.19 - $242.39
Q4 2022	10,634	$2,527	$213.29	$181.65 - $242.97
Q3 2022	11,908	$2,384	$190.74	$135.46 - $236.80
Q2 2022	13,925	$2,031	$141.87	$117.58 - $180.35
Q1 2022	18,462	$3,015	$152.35	$125.00 - $174.66
Q4 2021	20,948	$3,552	$185.86	$154.82 - $212.00
Q3 2021	21,659	$4,089	$187.58	$166.16 - $209.73
Q2 2021	21,662	$3,672	$146.46	$125.08 - $177.53
Q1 2021	19,023	$2,686	$150.49	$124.00 - $178.41
Q4 2020	19,531	$2,538	$133.53	$119.29 - $148.76
Q3 2020	19,913	$2,899	$142.10	$119.67 - $167.33
Q2 2020	18,041	$2,672	$134.81	$98.01 - $158.37
Q1 2020	12,197	$1,328	$115.43	$84.97 - $134.51
Q4 2019	26,204	$3,018	$99.70	$73.32 - $125.72
Q3 2019	17,110	$1,376	$79.11	$69.11 - $88.00
Q2 2019	22,369	$1,623	$76.72	$65.81 - $96.08
Q1 2019	20,716	$1,936	$83.64	$70.29 - $93.95
Q4 2018	22,820	$1,664	$76.92	$60.27 - $90.00
Q3 2018	19,929	$1,744	$100.59	$86.95 - $124.22
Q2 2018	27,025	$2,662	$99.19	$87.35 - $118.71
Q1 2018	33,261	$3,961	$128.92	$108.13 - $153.99
Q4 2017	34,505	$4,384	$125.65	$111.25 - $147.63
Q3 2016	9,678	$656	$70.55	$53.56 - $80.11
Q2 2016	14,377	$798	$63.00	$49.96 - $75.08
Q1 2016	14,377	$902	$66.49	$51.51 - $98.00
Q4 2015	48,030	$4,522	$92.72	$71.14 - $110.75
Q3 2015	22,007	$1,768	$111.10	$76.46 - $137.89
Q2 2015	16,154	$1,936	$119.50	$98.63 - $140.00