ALNYLAM PHARMACEUTICALS INC

Ticker: ALNY CUSIP: 02043Q107 Class: EQTY

BAKER BROS. ADVISORS LP's Holding History (CIK: 0001263508)

Note: Option positions (PUT/CALL) are excluded.

Q4 2016

Shares 11,340 Value ($000) $425 Avg Close $41.87 Range $31.38 - $71.67

Q3 2016

Shares 11,340 Value ($000) $769 Avg Close $70.55 Range $53.56 - $80.11

Q2 2016

Shares 11,340 Value ($000) $629 Avg Close $63.00 Range $49.96 - $75.08

Q1 2016

Shares 11,340 Value ($000) $712 Avg Close $66.49 Range $51.51 - $98.00

Q4 2015

Shares 11,340 Value ($000) $1,068 Avg Close $92.72 Range $71.14 - $110.75

Q3 2015

Shares 11,340 Value ($000) $911 Avg Close $111.10 Range $76.46 - $137.89

Q2 2015

Shares 11,340 Value ($000) $1,359 Avg Close $119.50 Range $98.63 - $140.00

Q1 2015

Shares 11,340 Value ($000) $1,184 Avg Close $101.34 Range $82.06 - $121.93

Q4 2014

Shares 11,600 Value ($000) $1,125 Avg Close $92.65 Range $72.80 - $111.49

Q3 2014

Shares 11,600 Value ($000) $906 Avg Close $64.51 Range $51.93 - $79.88

Q2 2014

Shares 11,600 Value ($000) $733 Avg Close $59.44 Range $47.03 - $71.40

Q1 2014

Shares 11,600 Value ($000) $779 Avg Close $77.42 Range $60.24 - $112.57

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2016	11,340	$425	$41.87	$31.38 - $71.67
Q3 2016	11,340	$769	$70.55	$53.56 - $80.11
Q2 2016	11,340	$629	$63.00	$49.96 - $75.08
Q1 2016	11,340	$712	$66.49	$51.51 - $98.00
Q4 2015	11,340	$1,068	$92.72	$71.14 - $110.75
Q3 2015	11,340	$911	$111.10	$76.46 - $137.89
Q2 2015	11,340	$1,359	$119.50	$98.63 - $140.00
Q1 2015	11,340	$1,184	$101.34	$82.06 - $121.93
Q4 2014	11,600	$1,125	$92.65	$72.80 - $111.49
Q3 2014	11,600	$906	$64.51	$51.93 - $79.88
Q2 2014	11,600	$733	$59.44	$47.03 - $71.40
Q1 2014	11,600	$779	$77.42	$60.24 - $112.57