ALNYLAM PHARMACEUTICALS INC

Ticker: ALNY CUSIP: 02043Q107 Class: EQTY

GUGGENHEIM CAPITAL LLC's Holding History (CIK: 0001283072)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 40,135 Value ($000) $15,960 Avg Close $442.56 Range $387.03 - $495.55

Q3 2025

Shares 8,625 Value ($000) $3,933 Avg Close $407.20 Range $309.57 - $484.21

Q2 2025

Shares 10,649 Value ($000) $3,473 Avg Close $276.71 Range $205.87 - $327.21

Q1 2025

Shares 12,367 Value ($000) $3,339 Avg Close $257.00 Range $230.79 - $300.90

Q4 2024

Shares 12,783 Value ($000) $3,008 Avg Close $262.99 Range $229.86 - $304.39

Q3 2024

Shares 15,248 Value ($000) $4,194 Avg Close $260.36 Range $231.01 - $287.55

Q2 2024

Shares 19,187 Value ($000) $4,662 Avg Close $157.87 Range $141.98 - $252.87

Q1 2024

Shares 21,162 Value ($000) $3,163 Avg Close $166.82 Range $143.52 - $199.38

Q4 2023

Shares 17,751 Value ($000) $3,398 Avg Close $170.34 Range $148.10 - $198.00

Q3 2023

Shares 17,244 Value ($000) $3,054 Avg Close $191.12 Range $168.65 - $218.88

Q2 2023

Shares 19,666 Value ($000) $3,735 Avg Close $198.26 Range $183.00 - $212.47

Q1 2023

Shares 19,986 Value ($000) $4,004 Avg Close $210.20 Range $179.19 - $242.39

Q4 2022

Shares 20,817 Value ($000) $4,947 Avg Close $213.29 Range $181.65 - $242.97

Q3 2022

Shares 19,257 Value ($000) $3,854 Avg Close $190.74 Range $135.46 - $236.80

Q2 2022

Shares 25,349 Value ($000) $3,697 Avg Close $141.87 Range $117.58 - $180.35

Q1 2022

Shares 25,744 Value ($000) $4,204 Avg Close $152.35 Range $125.00 - $174.66

Q4 2021

Shares 26,305 Value ($000) $4,461 Avg Close $185.86 Range $154.82 - $212.00

Q3 2021

Shares 23,844 Value ($000) $4,502 Avg Close $187.58 Range $166.16 - $209.73

Q2 2021

Shares 25,937 Value ($000) $4,397 Avg Close $146.46 Range $125.08 - $177.53

Q1 2021

Shares 29,438 Value ($000) $4,156 Avg Close $150.49 Range $124.00 - $178.41

Q4 2020

Shares 31,643 Value ($000) $4,113 Avg Close $133.53 Range $119.29 - $148.76

Q3 2020

Shares 38,044 Value ($000) $5,539 Avg Close $142.10 Range $119.67 - $167.33

Q2 2020

Shares 45,148 Value ($000) $6,687 Avg Close $134.81 Range $98.01 - $158.37

Q1 2020

Shares 41,818 Value ($000) $4,552 Avg Close $115.43 Range $84.97 - $134.51

Q4 2019

Shares 51,005 Value ($000) $5,874 Avg Close $99.70 Range $73.32 - $125.72

Q3 2019

Shares 50,690 Value ($000) $4,076 Avg Close $79.11 Range $69.11 - $88.00

Q4 2018

Shares 63,974 Value ($000) $4,664 Avg Close $76.92 Range $60.27 - $90.00

Q3 2018

Shares 60,501 Value ($000) $5,295 Avg Close $100.59 Range $86.95 - $124.22

Q2 2018

Shares 55,821 Value ($000) $5,498 Avg Close $99.19 Range $87.35 - $118.71

Q1 2018

Shares 53,084 Value ($000) $6,323 Avg Close $128.92 Range $108.13 - $153.99

Q4 2017

Shares 52,484 Value ($000) $6,667 Avg Close $125.65 Range $111.25 - $147.63

Q3 2017

Shares 85,467 Value ($000) $10,041 Avg Close $85.36 Range $70.76 - $119.02

Q2 2017

Shares 67,373 Value ($000) $5,375 Avg Close $63.91 Range $46.90 - $86.92

Q1 2017

Shares 84,857 Value ($000) $4,349 Avg Close $46.22 Range $35.98 - $60.41

Q4 2016

Shares 79,083 Value ($000) $2,961 Avg Close $41.87 Range $31.38 - $71.67

Q3 2016

Shares 74,518 Value ($000) $5,051 Avg Close $70.55 Range $53.56 - $80.11

Q2 2016

Shares 86,368 Value ($000) $4,793 Avg Close $63.00 Range $49.96 - $75.08

Q1 2016

Shares 90,662 Value ($000) $5,691 Avg Close $66.49 Range $51.51 - $98.00

Q4 2015

Shares 114,002 Value ($000) $10,732 Avg Close $92.72 Range $71.14 - $110.75

Q3 2015

Shares 142,543 Value ($000) $11,455 Avg Close $111.10 Range $76.46 - $137.89

Q2 2015

Shares 144,763 Value ($000) $17,353 Avg Close $119.50 Range $98.63 - $140.00

Q1 2015

Shares 136,340 Value ($000) $14,237 Avg Close $101.34 Range $82.06 - $121.93

Q4 2014

Shares 114,017 Value ($000) $11,060 Avg Close $92.65 Range $72.80 - $111.49

Q3 2014

Shares 99,576 Value ($000) $7,777 Avg Close $64.51 Range $51.93 - $79.88

Q2 2014

Shares 103,830 Value ($000) $6,559 Avg Close $59.44 Range $47.03 - $71.40

Q1 2014

Shares 114,457 Value ($000) $7,684 Avg Close $77.42 Range $60.24 - $112.57

Q4 2013

Shares 100,747 Value ($000) $6,481 Avg Close $59.65 Range $48.16 - $67.97

Q3 2013

Shares 108,096 Value ($000) $6,920 Avg Close $49.85 Range $31.75 - $65.83

Q2 2013

Shares 181,416 Value ($000) $5,626 Avg Close $26.61 Range $21.60 - $31.79

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	40,135	$15,960	$442.56	$387.03 - $495.55
Q3 2025	8,625	$3,933	$407.20	$309.57 - $484.21
Q2 2025	10,649	$3,473	$276.71	$205.87 - $327.21
Q1 2025	12,367	$3,339	$257.00	$230.79 - $300.90
Q4 2024	12,783	$3,008	$262.99	$229.86 - $304.39
Q3 2024	15,248	$4,194	$260.36	$231.01 - $287.55
Q2 2024	19,187	$4,662	$157.87	$141.98 - $252.87
Q1 2024	21,162	$3,163	$166.82	$143.52 - $199.38
Q4 2023	17,751	$3,398	$170.34	$148.10 - $198.00
Q3 2023	17,244	$3,054	$191.12	$168.65 - $218.88
Q2 2023	19,666	$3,735	$198.26	$183.00 - $212.47
Q1 2023	19,986	$4,004	$210.20	$179.19 - $242.39
Q4 2022	20,817	$4,947	$213.29	$181.65 - $242.97
Q3 2022	19,257	$3,854	$190.74	$135.46 - $236.80
Q2 2022	25,349	$3,697	$141.87	$117.58 - $180.35
Q1 2022	25,744	$4,204	$152.35	$125.00 - $174.66
Q4 2021	26,305	$4,461	$185.86	$154.82 - $212.00
Q3 2021	23,844	$4,502	$187.58	$166.16 - $209.73
Q2 2021	25,937	$4,397	$146.46	$125.08 - $177.53
Q1 2021	29,438	$4,156	$150.49	$124.00 - $178.41
Q4 2020	31,643	$4,113	$133.53	$119.29 - $148.76
Q3 2020	38,044	$5,539	$142.10	$119.67 - $167.33
Q2 2020	45,148	$6,687	$134.81	$98.01 - $158.37
Q1 2020	41,818	$4,552	$115.43	$84.97 - $134.51
Q4 2019	51,005	$5,874	$99.70	$73.32 - $125.72
Q3 2019	50,690	$4,076	$79.11	$69.11 - $88.00
Q4 2018	63,974	$4,664	$76.92	$60.27 - $90.00
Q3 2018	60,501	$5,295	$100.59	$86.95 - $124.22
Q2 2018	55,821	$5,498	$99.19	$87.35 - $118.71
Q1 2018	53,084	$6,323	$128.92	$108.13 - $153.99
Q4 2017	52,484	$6,667	$125.65	$111.25 - $147.63
Q3 2017	85,467	$10,041	$85.36	$70.76 - $119.02
Q2 2017	67,373	$5,375	$63.91	$46.90 - $86.92
Q1 2017	84,857	$4,349	$46.22	$35.98 - $60.41
Q4 2016	79,083	$2,961	$41.87	$31.38 - $71.67
Q3 2016	74,518	$5,051	$70.55	$53.56 - $80.11
Q2 2016	86,368	$4,793	$63.00	$49.96 - $75.08
Q1 2016	90,662	$5,691	$66.49	$51.51 - $98.00
Q4 2015	114,002	$10,732	$92.72	$71.14 - $110.75
Q3 2015	142,543	$11,455	$111.10	$76.46 - $137.89
Q2 2015	144,763	$17,353	$119.50	$98.63 - $140.00
Q1 2015	136,340	$14,237	$101.34	$82.06 - $121.93
Q4 2014	114,017	$11,060	$92.65	$72.80 - $111.49
Q3 2014	99,576	$7,777	$64.51	$51.93 - $79.88
Q2 2014	103,830	$6,559	$59.44	$47.03 - $71.40
Q1 2014	114,457	$7,684	$77.42	$60.24 - $112.57
Q4 2013	100,747	$6,481	$59.65	$48.16 - $67.97
Q3 2013	108,096	$6,920	$49.85	$31.75 - $65.83
Q2 2013	181,416	$5,626	$26.61	$21.60 - $31.79