ALNYLAM PHARMACEUTICALS INC

Ticker: ALNY CUSIP: 02043Q107 Class: EQTY

Zurcher Kantonalbank (Zurich Cantonalbank)'s Holding History (CIK: 0001368163)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 89,804 Value ($000) $35,711 Avg Close $442.56 Range $387.03 - $495.55

Q3 2025

Shares 40,944 Value ($000) $18,670 Avg Close $407.20 Range $309.57 - $484.21

Q2 2025

Shares 30,751 Value ($000) $10,028 Avg Close $276.71 Range $205.87 - $327.21

Q1 2025

Shares 57,119 Value ($000) $15,423 Avg Close $257.00 Range $230.79 - $300.90

Q4 2024

Shares 54,406 Value ($000) $12,802 Avg Close $262.99 Range $229.86 - $304.39

Q3 2024

Shares 54,570 Value ($000) $15,008 Avg Close $260.36 Range $231.01 - $287.55

Q2 2024

Shares 65,485 Value ($000) $15,913 Avg Close $157.87 Range $141.98 - $252.87

Q1 2024

Shares 50,014 Value ($000) $7,475 Avg Close $166.82 Range $143.52 - $199.38

Q4 2023

Shares 45,080 Value ($000) $8,629 Avg Close $170.34 Range $148.10 - $198.00

Q3 2023

Shares 22,607 Value ($000) $4,004 Avg Close $191.12 Range $168.65 - $218.88

Q2 2023

Shares 20,406 Value ($000) $3,876 Avg Close $198.26 Range $183.00 - $212.47

Q1 2023

Shares 19,946 Value ($000) $3,996 Avg Close $210.20 Range $179.19 - $242.39

Q4 2022

Shares 18,914 Value ($000) $4,495 Avg Close $213.29 Range $181.65 - $242.97

Q3 2022

Shares 46,260 Value ($000) $9,259 Avg Close $190.74 Range $135.46 - $236.80

Q2 2022

Shares 46,054 Value ($000) $6,717 Avg Close $141.87 Range $117.58 - $180.35

Q1 2022

Shares 18,409 Value ($000) $3,006 Avg Close $152.35 Range $125.00 - $174.66

Q4 2021

Shares 18,265 Value ($000) $3,097 Avg Close $185.86 Range $154.82 - $212.00

Q3 2021

Shares 27,101 Value ($000) $5,117 Avg Close $187.58 Range $166.16 - $209.73

Q2 2021

Shares 26,327 Value ($000) $4,463 Avg Close $146.46 Range $125.08 - $177.53

Q1 2021

Shares 26,331 Value ($000) $3,718 Avg Close $150.49 Range $124.00 - $178.41

Q4 2020

Shares 25,980 Value ($000) $3,377 Avg Close $133.53 Range $119.29 - $148.76

Q3 2020

Shares 25,878 Value ($000) $3,768 Avg Close $142.10 Range $119.67 - $167.33

Q2 2020

Shares 23,461 Value ($000) $3,475 Avg Close $134.81 Range $98.01 - $158.37

Q1 2020

Shares 24,501 Value ($000) $2,667 Avg Close $115.43 Range $84.97 - $134.51

Q4 2019

Shares 23,458 Value ($000) $2,702 Avg Close $99.70 Range $73.32 - $125.72

Q3 2019

Shares 18,411 Value ($000) $1,481 Avg Close $79.11 Range $69.11 - $88.00

Q2 2019

Shares 17,413 Value ($000) $1,263 Avg Close $76.72 Range $65.81 - $96.08

Q1 2019

Shares 17,998 Value ($000) $1,682 Avg Close $83.64 Range $70.29 - $93.95

Q4 2018

Shares 18,198 Value ($000) $1,327 Avg Close $76.92 Range $60.27 - $90.00

Q3 2018

Shares 18,614 Value ($000) $1,629 Avg Close $100.59 Range $86.95 - $124.22

Q2 2018

Shares 18,314 Value ($000) $1,804 Avg Close $99.19 Range $87.35 - $118.71

Q1 2018

Shares 20,035 Value ($000) $2,386 Avg Close $128.92 Range $108.13 - $153.99

Q4 2017

Shares 19,674 Value ($000) $2,500 Avg Close $125.65 Range $111.25 - $147.63

Q3 2017

Shares 5,212 Value ($000) $612 Avg Close $85.36 Range $70.76 - $119.02

Q2 2017

Shares 3,512 Value ($000) $280 Avg Close $63.91 Range $46.90 - $86.92

Q1 2017

Shares 2,894 Value ($000) $148 Avg Close $46.22 Range $35.98 - $60.41

Q3 2016

Shares 14,648 Value ($000) $993 Avg Close $70.55 Range $53.56 - $80.11

Q2 2016

Shares 9,248 Value ($000) $513 Avg Close $63.00 Range $49.96 - $75.08

Q1 2016

Shares 8,308 Value ($000) $521 Avg Close $66.49 Range $51.51 - $98.00

Q4 2015

Shares 8,308 Value ($000) $782 Avg Close $92.72 Range $71.14 - $110.75

Q3 2015

Shares 6,358 Value ($000) $511 Avg Close $111.10 Range $76.46 - $137.89

Q2 2015

Shares 5,425 Value ($000) $650 Avg Close $119.50 Range $98.63 - $140.00

Q1 2015

Shares 5,198 Value ($000) $543 Avg Close $101.34 Range $82.06 - $121.93

Q3 2014

Shares 10,000 Value ($000) $781 Avg Close $64.51 Range $51.93 - $79.88

Q2 2014

Shares 60,000 Value ($000) $3,790 Avg Close $59.44 Range $47.03 - $71.40

Q1 2014

Shares 23,000 Value ($000) $1,544 Avg Close $77.42 Range $60.24 - $112.57

Q4 2013

Shares 23,000 Value ($000) $1,480 Avg Close $59.65 Range $48.16 - $67.97

Q3 2013

Shares 21,000 Value ($000) $1,344 Avg Close $49.85 Range $31.75 - $65.83

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	89,804	$35,711	$442.56	$387.03 - $495.55
Q3 2025	40,944	$18,670	$407.20	$309.57 - $484.21
Q2 2025	30,751	$10,028	$276.71	$205.87 - $327.21
Q1 2025	57,119	$15,423	$257.00	$230.79 - $300.90
Q4 2024	54,406	$12,802	$262.99	$229.86 - $304.39
Q3 2024	54,570	$15,008	$260.36	$231.01 - $287.55
Q2 2024	65,485	$15,913	$157.87	$141.98 - $252.87
Q1 2024	50,014	$7,475	$166.82	$143.52 - $199.38
Q4 2023	45,080	$8,629	$170.34	$148.10 - $198.00
Q3 2023	22,607	$4,004	$191.12	$168.65 - $218.88
Q2 2023	20,406	$3,876	$198.26	$183.00 - $212.47
Q1 2023	19,946	$3,996	$210.20	$179.19 - $242.39
Q4 2022	18,914	$4,495	$213.29	$181.65 - $242.97
Q3 2022	46,260	$9,259	$190.74	$135.46 - $236.80
Q2 2022	46,054	$6,717	$141.87	$117.58 - $180.35
Q1 2022	18,409	$3,006	$152.35	$125.00 - $174.66
Q4 2021	18,265	$3,097	$185.86	$154.82 - $212.00
Q3 2021	27,101	$5,117	$187.58	$166.16 - $209.73
Q2 2021	26,327	$4,463	$146.46	$125.08 - $177.53
Q1 2021	26,331	$3,718	$150.49	$124.00 - $178.41
Q4 2020	25,980	$3,377	$133.53	$119.29 - $148.76
Q3 2020	25,878	$3,768	$142.10	$119.67 - $167.33
Q2 2020	23,461	$3,475	$134.81	$98.01 - $158.37
Q1 2020	24,501	$2,667	$115.43	$84.97 - $134.51
Q4 2019	23,458	$2,702	$99.70	$73.32 - $125.72
Q3 2019	18,411	$1,481	$79.11	$69.11 - $88.00
Q2 2019	17,413	$1,263	$76.72	$65.81 - $96.08
Q1 2019	17,998	$1,682	$83.64	$70.29 - $93.95
Q4 2018	18,198	$1,327	$76.92	$60.27 - $90.00
Q3 2018	18,614	$1,629	$100.59	$86.95 - $124.22
Q2 2018	18,314	$1,804	$99.19	$87.35 - $118.71
Q1 2018	20,035	$2,386	$128.92	$108.13 - $153.99
Q4 2017	19,674	$2,500	$125.65	$111.25 - $147.63
Q3 2017	5,212	$612	$85.36	$70.76 - $119.02
Q2 2017	3,512	$280	$63.91	$46.90 - $86.92
Q1 2017	2,894	$148	$46.22	$35.98 - $60.41
Q3 2016	14,648	$993	$70.55	$53.56 - $80.11
Q2 2016	9,248	$513	$63.00	$49.96 - $75.08
Q1 2016	8,308	$521	$66.49	$51.51 - $98.00
Q4 2015	8,308	$782	$92.72	$71.14 - $110.75
Q3 2015	6,358	$511	$111.10	$76.46 - $137.89
Q2 2015	5,425	$650	$119.50	$98.63 - $140.00
Q1 2015	5,198	$543	$101.34	$82.06 - $121.93
Q3 2014	10,000	$781	$64.51	$51.93 - $79.88
Q2 2014	60,000	$3,790	$59.44	$47.03 - $71.40
Q1 2014	23,000	$1,544	$77.42	$60.24 - $112.57
Q4 2013	23,000	$1,480	$59.65	$48.16 - $67.97
Q3 2013	21,000	$1,344	$49.85	$31.75 - $65.83