ALNYLAM PHARMACEUTICALS INC

Ticker: ALNY CUSIP: 02043Q107 Class: EQTY

Robeco Institutional Asset Management B.V.'s Holding History (CIK: 0001418773)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 144,721 Value ($000) $57,548 Avg Close $442.56 Range $387.03 - $495.55

Q3 2025

Shares 113,074 Value ($000) $51,562 Avg Close $407.20 Range $309.57 - $484.21

Q2 2025

Shares 96,368 Value ($000) $31,425 Avg Close $276.71 Range $205.87 - $327.21

Q1 2025

Shares 103,481 Value ($000) $27,942 Avg Close $257.00 Range $230.79 - $300.90

Q4 2024

Shares 99,994 Value ($000) $23,530 Avg Close $262.99 Range $229.86 - $304.39

Q3 2024

Shares 73,568 Value ($000) $20,233 Avg Close $260.36 Range $231.01 - $287.55

Q2 2024

Shares 49,670 Value ($000) $12,070 Avg Close $157.87 Range $141.98 - $252.87

Q1 2024

Shares 28,840 Value ($000) $4,310 Avg Close $166.82 Range $143.52 - $199.38

Q4 2023

Shares 24,135 Value ($000) $4,620 Avg Close $170.34 Range $148.10 - $198.00

Q3 2023

Shares 8,036 Value ($000) $1,423 Avg Close $191.12 Range $168.65 - $218.88

Q2 2023

Shares 27,143 Value ($000) $5,156 Avg Close $198.26 Range $183.00 - $212.47

Q1 2023

Shares 52,758 Value ($000) $10,568 Avg Close $210.20 Range $179.19 - $242.39

Q4 2022

Shares 51,987 Value ($000) $12,355 Avg Close $213.29 Range $181.65 - $242.97

Q3 2022

Shares 39,359 Value ($000) $7,878 Avg Close $190.74 Range $135.46 - $236.80

Q2 2022

Shares 2,411 Value ($000) $352 Avg Close $141.87 Range $117.58 - $180.35

Q1 2022

Shares 2,990 Value ($000) $488 Avg Close $152.35 Range $125.00 - $174.66

Q4 2021

Shares 39 Value ($000) $7 Avg Close $185.86 Range $154.82 - $212.00

Q2 2021

Shares 3,602 Value ($000) $611 Avg Close $146.46 Range $125.08 - $177.53

Q1 2021

Shares 8,810 Value ($000) $1,243 Avg Close $150.49 Range $124.00 - $178.41

Q4 2020

Shares 14,254 Value ($000) $1,851 Avg Close $133.53 Range $119.29 - $148.76

Q3 2020

Shares 34,853 Value ($000) $5,074 Avg Close $142.10 Range $119.67 - $167.33

Q2 2020

Shares 60,387 Value ($000) $8,943 Avg Close $134.81 Range $98.01 - $158.37

Q1 2020

Shares 2,517 Value ($000) $273 Avg Close $115.43 Range $84.97 - $134.51

Q3 2018

Shares 1,427 Value ($000) $125 Avg Close $100.59 Range $86.95 - $124.22

Q2 2018

Shares 1,427 Value ($000) $141 Avg Close $99.19 Range $87.35 - $118.71

Q1 2018

Shares 1,427 Value ($000) $170 Avg Close $128.92 Range $108.13 - $153.99

Q2 2015

Shares 2,980 Value ($000) $357 Avg Close $119.50 Range $98.63 - $140.00

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	144,721	$57,548	$442.56	$387.03 - $495.55
Q3 2025	113,074	$51,562	$407.20	$309.57 - $484.21
Q2 2025	96,368	$31,425	$276.71	$205.87 - $327.21
Q1 2025	103,481	$27,942	$257.00	$230.79 - $300.90
Q4 2024	99,994	$23,530	$262.99	$229.86 - $304.39
Q3 2024	73,568	$20,233	$260.36	$231.01 - $287.55
Q2 2024	49,670	$12,070	$157.87	$141.98 - $252.87
Q1 2024	28,840	$4,310	$166.82	$143.52 - $199.38
Q4 2023	24,135	$4,620	$170.34	$148.10 - $198.00
Q3 2023	8,036	$1,423	$191.12	$168.65 - $218.88
Q2 2023	27,143	$5,156	$198.26	$183.00 - $212.47
Q1 2023	52,758	$10,568	$210.20	$179.19 - $242.39
Q4 2022	51,987	$12,355	$213.29	$181.65 - $242.97
Q3 2022	39,359	$7,878	$190.74	$135.46 - $236.80
Q2 2022	2,411	$352	$141.87	$117.58 - $180.35
Q1 2022	2,990	$488	$152.35	$125.00 - $174.66
Q4 2021	39	$7	$185.86	$154.82 - $212.00
Q2 2021	3,602	$611	$146.46	$125.08 - $177.53
Q1 2021	8,810	$1,243	$150.49	$124.00 - $178.41
Q4 2020	14,254	$1,851	$133.53	$119.29 - $148.76
Q3 2020	34,853	$5,074	$142.10	$119.67 - $167.33
Q2 2020	60,387	$8,943	$134.81	$98.01 - $158.37
Q1 2020	2,517	$273	$115.43	$84.97 - $134.51
Q3 2018	1,427	$125	$100.59	$86.95 - $124.22
Q2 2018	1,427	$141	$99.19	$87.35 - $118.71
Q1 2018	1,427	$170	$128.92	$108.13 - $153.99
Q2 2015	2,980	$357	$119.50	$98.63 - $140.00