ALNYLAM PHARMACEUTICALS INC

Ticker: ALNY CUSIP: 02043Q107 Class: EQTY

Artisan Partners Limited Partnership's Holding History (CIK: 0001466153)

Note: Option positions (PUT/CALL) are excluded.

Q1 2022

Shares 117,345 Value ($000) $19,161 Avg Close $152.35 Range $125.00 - $174.66

Q4 2021

Shares 239,136 Value ($000) $40,553 Avg Close $185.86 Range $154.82 - $212.00

Q3 2021

Shares 242,784 Value ($000) $45,840 Avg Close $187.58 Range $166.16 - $209.73

Q2 2021

Shares 238,582 Value ($000) $40,444 Avg Close $146.46 Range $125.08 - $177.53

Q1 2021

Shares 228,188 Value ($000) $32,218 Avg Close $150.49 Range $124.00 - $178.41

Q4 2020

Shares 200,173 Value ($000) $26,016 Avg Close $133.53 Range $119.29 - $148.76

Q3 2020

Shares 163,692 Value ($000) $23,834 Avg Close $142.10 Range $119.67 - $167.33

Q2 2020

Shares 126,825 Value ($000) $18,784 Avg Close $134.81 Range $98.01 - $158.37

Q1 2020

Shares 106,226 Value ($000) $11,563 Avg Close $115.43 Range $84.97 - $134.51

Q3 2016

Shares 221,733 Value ($000) $15,029 Avg Close $70.55 Range $53.56 - $80.11

Q2 2016

Shares 225,203 Value ($000) $12,497 Avg Close $63.00 Range $49.96 - $75.08

Q1 2016

Shares 233,659 Value ($000) $14,667 Avg Close $66.49 Range $51.51 - $98.00

Q4 2015

Shares 238,023 Value ($000) $22,407 Avg Close $92.72 Range $71.14 - $110.75

Q3 2015

Shares 244,904 Value ($000) $19,680 Avg Close $111.10 Range $76.46 - $137.89

Q2 2015

Shares 1,019,280 Value ($000) $122,181 Avg Close $119.50 Range $98.63 - $140.00

Q1 2015

Shares 1,084,560 Value ($000) $113,250 Avg Close $101.34 Range $82.06 - $121.93

Q4 2014

Shares 291,382 Value ($000) $28,264 Avg Close $92.65 Range $72.80 - $111.49

Q3 2014

Shares 547,856 Value ($000) $42,788 Avg Close $64.51 Range $51.93 - $79.88

Q2 2014

Shares 574,858 Value ($000) $36,314 Avg Close $59.44 Range $47.03 - $71.40

Q1 2014

Shares 518,883 Value ($000) $34,838 Avg Close $77.42 Range $60.24 - $112.57

Q4 2013

Shares 443,722 Value ($000) $28,545 Avg Close $59.65 Range $48.16 - $67.97

Q3 2013

Shares 422,823 Value ($000) $27,065 Avg Close $49.85 Range $31.75 - $65.83

Period	Shares	Value ($000)	Average Close	Price Range
Q1 2022	117,345	$19,161	$152.35	$125.00 - $174.66
Q4 2021	239,136	$40,553	$185.86	$154.82 - $212.00
Q3 2021	242,784	$45,840	$187.58	$166.16 - $209.73
Q2 2021	238,582	$40,444	$146.46	$125.08 - $177.53
Q1 2021	228,188	$32,218	$150.49	$124.00 - $178.41
Q4 2020	200,173	$26,016	$133.53	$119.29 - $148.76
Q3 2020	163,692	$23,834	$142.10	$119.67 - $167.33
Q2 2020	126,825	$18,784	$134.81	$98.01 - $158.37
Q1 2020	106,226	$11,563	$115.43	$84.97 - $134.51
Q3 2016	221,733	$15,029	$70.55	$53.56 - $80.11
Q2 2016	225,203	$12,497	$63.00	$49.96 - $75.08
Q1 2016	233,659	$14,667	$66.49	$51.51 - $98.00
Q4 2015	238,023	$22,407	$92.72	$71.14 - $110.75
Q3 2015	244,904	$19,680	$111.10	$76.46 - $137.89
Q2 2015	1,019,280	$122,181	$119.50	$98.63 - $140.00
Q1 2015	1,084,560	$113,250	$101.34	$82.06 - $121.93
Q4 2014	291,382	$28,264	$92.65	$72.80 - $111.49
Q3 2014	547,856	$42,788	$64.51	$51.93 - $79.88
Q2 2014	574,858	$36,314	$59.44	$47.03 - $71.40
Q1 2014	518,883	$34,838	$77.42	$60.24 - $112.57
Q4 2013	443,722	$28,545	$59.65	$48.16 - $67.97
Q3 2013	422,823	$27,065	$49.85	$31.75 - $65.83