ALNYLAM PHARMACEUTICALS INC

Ticker: ALNY CUSIP: 02043Q107 Class: EQTY

Brevan Howard Capital Management LP's Holding History (CIK: 0001512857)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 4,437 Value ($000) $1,764 Avg Close $442.56 Range $387.03 - $495.55

Q3 2025

Shares 6,170 Value ($000) $2,814 Avg Close $407.20 Range $309.57 - $484.21

Q4 2024

Shares 1,333 Value ($000) $314 Avg Close $262.99 Range $229.86 - $304.39

Q3 2024

Shares 1,289 Value ($000) $355 Avg Close $260.36 Range $231.01 - $287.55

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	4,437	$1,764	$442.56	$387.03 - $495.55
Q3 2025	6,170	$2,814	$407.20	$309.57 - $484.21
Q4 2024	1,333	$314	$262.99	$229.86 - $304.39
Q3 2024	1,289	$355	$260.36	$231.01 - $287.55