ALNYLAM PHARMACEUTICALS INC

Ticker: ALNY CUSIP: 02043Q107 Class: EQTY

Assenagon Asset Management S.A.'s Holding History (CIK: 0001546007)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 25,590 Value ($000) $10,176 Avg Close $442.56 Range $387.03 - $495.55

Q3 2025

Shares 80,381 Value ($000) $36,654 Avg Close $407.20 Range $309.57 - $484.21

Q2 2025

Shares 17,686 Value ($000) $5,767 Avg Close $276.71 Range $205.87 - $327.21

Q1 2025

Shares 6,405 Value ($000) $1,729 Avg Close $257.00 Range $230.79 - $300.90

Q4 2024

Shares 19,918 Value ($000) $4,687 Avg Close $262.99 Range $229.86 - $304.39

Q3 2024

Shares 17,633 Value ($000) $4,850 Avg Close $260.36 Range $231.01 - $287.55

Q2 2024

Shares 122,796 Value ($000) $29,839 Avg Close $157.87 Range $141.98 - $252.87

Q1 2024

Shares 60,342 Value ($000) $9,018 Avg Close $166.82 Range $143.52 - $199.38

Q4 2023

Shares 14,166 Value ($000) $2,712 Avg Close $170.34 Range $148.10 - $198.00

Q3 2023

Shares 6,730 Value ($000) $1,192 Avg Close $191.12 Range $168.65 - $218.88

Q2 2023

Shares 90,862 Value ($000) $17,258 Avg Close $198.26 Range $183.00 - $212.47

Q1 2023

Shares 215,191 Value ($000) $43,107 Avg Close $210.20 Range $179.19 - $242.39

Q4 2022

Shares 7,827 Value ($000) $2 Avg Close $213.29 Range $181.65 - $242.97

Q3 2022

Shares 6,258 Value ($000) $1,253 Avg Close $190.74 Range $135.46 - $236.80

Q4 2021

Shares 174,443 Value ($000) $29,582 Avg Close $185.86 Range $154.82 - $212.00

Q3 2021

Shares 334,289 Value ($000) $63,117 Avg Close $187.58 Range $166.16 - $209.73

Q2 2021

Shares 283,800 Value ($000) $48,110 Avg Close $146.46 Range $125.08 - $177.53

Q1 2021

Shares 123,768 Value ($000) $17,475 Avg Close $150.49 Range $124.00 - $178.41

Q4 2020

Shares 22,633 Value ($000) $2,942 Avg Close $133.53 Range $119.29 - $148.76

Q3 2020

Shares 43,185 Value ($000) $6,288 Avg Close $142.10 Range $119.67 - $167.33

Q2 2020

Shares 118,519 Value ($000) $17,554 Avg Close $134.81 Range $98.01 - $158.37

Q1 2020

Shares 23,912 Value ($000) $2,603 Avg Close $115.43 Range $84.97 - $134.51

Q3 2019

Shares 27,286 Value ($000) $2,194 Avg Close $79.11 Range $69.11 - $88.00

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	25,590	$10,176	$442.56	$387.03 - $495.55
Q3 2025	80,381	$36,654	$407.20	$309.57 - $484.21
Q2 2025	17,686	$5,767	$276.71	$205.87 - $327.21
Q1 2025	6,405	$1,729	$257.00	$230.79 - $300.90
Q4 2024	19,918	$4,687	$262.99	$229.86 - $304.39
Q3 2024	17,633	$4,850	$260.36	$231.01 - $287.55
Q2 2024	122,796	$29,839	$157.87	$141.98 - $252.87
Q1 2024	60,342	$9,018	$166.82	$143.52 - $199.38
Q4 2023	14,166	$2,712	$170.34	$148.10 - $198.00
Q3 2023	6,730	$1,192	$191.12	$168.65 - $218.88
Q2 2023	90,862	$17,258	$198.26	$183.00 - $212.47
Q1 2023	215,191	$43,107	$210.20	$179.19 - $242.39
Q4 2022	7,827	$2	$213.29	$181.65 - $242.97
Q3 2022	6,258	$1,253	$190.74	$135.46 - $236.80
Q4 2021	174,443	$29,582	$185.86	$154.82 - $212.00
Q3 2021	334,289	$63,117	$187.58	$166.16 - $209.73
Q2 2021	283,800	$48,110	$146.46	$125.08 - $177.53
Q1 2021	123,768	$17,475	$150.49	$124.00 - $178.41
Q4 2020	22,633	$2,942	$133.53	$119.29 - $148.76
Q3 2020	43,185	$6,288	$142.10	$119.67 - $167.33
Q2 2020	118,519	$17,554	$134.81	$98.01 - $158.37
Q1 2020	23,912	$2,603	$115.43	$84.97 - $134.51
Q3 2019	27,286	$2,194	$79.11	$69.11 - $88.00