ALPINE IMMUNE SCIENCES INC

CUSIP: 02083G100 Class: Common Stock

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q1 2024
Shares 519,971 Value ($000) $20,612 Avg Close — Range —
Q4 2023
Shares 378,413 Value ($000) $7,213 Avg Close — Range —
Q3 2023
Shares 190,589 Value ($000) $2,182 Avg Close — Range —
Q2 2023
Shares 58,028 Value ($000) $597 Avg Close — Range —
Q3 2022
Shares 21,924 Value ($000) $158 Avg Close — Range —
Q2 2022
Shares 20,030 Value ($000) $170 Avg Close — Range —
Q1 2022
Shares 47,708 Value ($000) $428 Avg Close — Range —
Q4 2021
Shares 79,682 Value ($000) $1,104 Avg Close — Range —
Q3 2021
Shares 39,218 Value ($000) $418 Avg Close — Range —
Q2 2021
Shares 16,914 Value ($000) $152 Avg Close — Range —
Q1 2021
Shares 107,381 Value ($000) $1,138 Avg Close — Range —
Q4 2020
Shares 148,443 Value ($000) $1,870 Avg Close — Range —
Q3 2020
Shares 81,365 Value ($000) $715 Avg Close — Range —
Q2 2020
Shares 78,299 Value ($000) $760 Avg Close — Range —