ALTO NEUROSCIENCE INC

Ticker: ANRO CUSIP: 02157Q109 Class: Common Stock

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 140,317 Value ($000) $2,498 Avg Close $12.59 Range $4.00 - $20.91

Q3 2025

Shares 116,579 Value ($000) $469 Avg Close $3.32 Range $2.20 - $4.25

Q2 2025

Shares 44,735 Value ($000) $98 Avg Close $2.38 Range $1.60 - $3.08

Q1 2025

Shares 26,142 Value ($000) $56 Avg Close $3.58 Range $2.06 - $4.88

Q4 2024

Shares 30,700 Value ($000) $130 Avg Close $6.24 Range $3.56 - $15.04

Q3 2024

Shares 12,940 Value ($000) $148 Avg Close $12.24 Range $7.91 - $17.55

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	140,317	$2,498	$12.59	$4.00 - $20.91
Q3 2025	116,579	$469	$3.32	$2.20 - $4.25
Q2 2025	44,735	$98	$2.38	$1.60 - $3.08
Q1 2025	26,142	$56	$3.58	$2.06 - $4.88
Q4 2024	30,700	$130	$6.24	$3.56 - $15.04
Q3 2024	12,940	$148	$12.24	$7.91 - $17.55