ALTO NEUROSCIENCE INC

Ticker: ANRO CUSIP: 02157Q109 Class: Common Stock

TWO SIGMA ADVISERS, LP's Holding History (CIK: 0001478735)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 160,100 Value ($000) $2,850 Avg Close $12.59 Range $4.00 - $20.91

Q3 2025

Shares 149,900 Value ($000) $603 Avg Close $3.32 Range $2.20 - $4.25

Q2 2025

Shares 82,200 Value ($000) $181 Avg Close $2.38 Range $1.60 - $3.08

Q1 2025

Shares 14,300 Value ($000) $31 Avg Close $3.58 Range $2.06 - $4.88

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	160,100	$2,850	$12.59	$4.00 - $20.91
Q3 2025	149,900	$603	$3.32	$2.20 - $4.25
Q2 2025	82,200	$181	$2.38	$1.60 - $3.08
Q1 2025	14,300	$31	$3.58	$2.06 - $4.88