AMGEN INC

Ticker: AMGN CUSIP: 031162100 Class: COM

ADAGE CAPITAL PARTNERS GP, L.L.C.'s Holding History (CIK: 0001165408)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 274,292 Value ($000) $89,779 Avg Close $315.95 Range $281.00 - $346.38

Q3 2025

Shares 237,692 Value ($000) $67,077 Avg Close $286.59 Range $267.86 - $306.59

Q2 2025

Shares 188,864 Value ($000) $52,733 Avg Close $277.77 Range $255.23 - $307.44

Q1 2025

Shares 225,868 Value ($000) $70,369 Avg Close $287.24 Range $248.95 - $327.92

Q4 2024

Shares 304,727 Value ($000) $79,424 Avg Close $286.05 Range $245.31 - $316.26

Q3 2024

Shares 601,662 Value ($000) $193,862 Avg Close $313.17 Range $292.07 - $330.95

Q2 2024

Shares 578,296 Value ($000) $180,689 Avg Close $279.32 Range $246.97 - $311.17

Q1 2024

Shares 418,567 Value ($000) $119,007 Avg Close $276.08 Range $254.07 - $309.96

Q4 2023

Shares 976,584 Value ($000) $281,276 Avg Close $255.10 Range $232.90 - $271.72

Q3 2023

Shares 722,250 Value ($000) $194,112 Avg Close $231.86 Range $202.11 - $255.21

Q2 2023

Shares 364,113 Value ($000) $80,840 Avg Close $213.65 Range $195.88 - $235.05

Q1 2023

Shares 355,756 Value ($000) $86,004 Avg Close $224.03 Range $206.60 - $251.53

Q4 2022

Shares 373,240 Value ($000) $98,028 Avg Close $242.73 Range $204.31 - $267.70

Q3 2021

Shares 169,238 Value ($000) $35,988 Avg Close $200.25 Range $184.86 - $217.02

Q2 2021

Shares 38,038 Value ($000) $9,272 Avg Close $212.50 Range $198.84 - $224.64

Q1 2021

Shares 441,038 Value ($000) $109,735 Avg Close $204.69 Range $189.57 - $236.38

Q4 2020

Shares 503,138 Value ($000) $115,681 Avg Close $196.32 Range $178.44 - $219.36

Q3 2020

Shares 621,167 Value ($000) $157,876 Avg Close $209.54 Range $196.05 - $223.35

Q2 2020

Shares 833,572 Value ($000) $196,606 Avg Close $191.68 Range $162.60 - $206.00

Q1 2020

Shares 619,872 Value ($000) $125,667 Avg Close $182.24 Range $148.24 - $202.72

Q4 2019

Shares 410,547 Value ($000) $98,971 Avg Close $182.69 Range $155.91 - $203.67

Q3 2019

Shares 372,247 Value ($000) $72,034 Avg Close $158.01 Range $141.97 - $174.23

Q2 2019

Shares 78,947 Value ($000) $14,548 Avg Close $146.19 Range $135.21 - $160.07

Q1 2019

Shares 213,247 Value ($000) $40,513 Avg Close $154.67 Range $144.94 - $164.86

Q4 2018

Shares 413,055 Value ($000) $80,409 Avg Close $156.83 Range $143.85 - $168.62

Q3 2018

Shares 452,755 Value ($000) $93,852 Avg Close $157.37 Range $145.39 - $168.41

Q2 2018

Shares 735,055 Value ($000) $135,684 Avg Close $140.24 Range $128.97 - $149.68

Q1 2018

Shares 575,907 Value ($000) $98,181 Avg Close $144.43 Range $131.87 - $157.72

Q4 2017

Shares 929,409 Value ($000) $161,624 Avg Close $138.21 Range $131.02 - $147.91

Q3 2017

Shares 816,109 Value ($000) $152,164 Avg Close $137.50 Range $129.63 - $148.76

Q2 2017

Shares 927,009 Value ($000) $159,659 Avg Close $125.35 Range $117.66 - $135.67

Q1 2017

Shares 989,109 Value ($000) $162,283 Avg Close $127.19 Range $112.17 - $141.42

Q4 2016

Shares 916,709 Value ($000) $134,032 Avg Close $114.37 Range $101.21 - $127.75

Q3 2016

Shares 940,409 Value ($000) $156,870 Avg Close $127.72 Range $114.64 - $133.93

Q2 2016

Shares 1,085,109 Value ($000) $165,099 Avg Close $116.70 Range $108.29 - $123.20

Q1 2016

Shares 1,092,959 Value ($000) $163,867 Avg Close $110.79 Range $103.99 - $119.01

Q4 2015

Shares 1,291,559 Value ($000) $209,659 Avg Close $116.50 Range $100.25 - $122.74

Q3 2015

Shares 1,290,159 Value ($000) $178,455 Avg Close $116.24 Range $96.15 - $133.76

Q2 2015

Shares 972,959 Value ($000) $149,369 Avg Close $117.59 Range $110.98 - $127.09

Q1 2015

Shares 747,959 Value ($000) $119,561 Avg Close $115.04 Range $107.36 - $126.18

Q4 2014

Shares 584,621 Value ($000) $93,124 Avg Close $113.30 Range $92.62 - $126.09

Q3 2014

Shares 253,500 Value ($000) $35,607 Avg Close $94.52 Range $82.98 - $104.80

Q2 2014

Shares 720,400 Value ($000) $85,274 Avg Close $83.37 Range $77.69 - $91.37

Q1 2014

Shares 953,900 Value ($000) $117,654 Avg Close $86.89 Range $80.81 - $92.60

Q4 2013

Shares 1,367,300 Value ($000) $155,982 Avg Close $81.11 Range $75.24 - $85.16

Q3 2013

Shares 2,071,500 Value ($000) $231,853 Avg Close $76.98 Range $67.33 - $83.88

Q2 2013

Shares 445,348 Value ($000) $43,938 Avg Close $73.34 Range $66.69 - $81.06

Q1 2013

Shares 553,148 Value ($000) $56,703 Avg Close $62.49 Range $57.21 - $72.37

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	274,292	$89,779	$315.95	$281.00 - $346.38
Q3 2025	237,692	$67,077	$286.59	$267.86 - $306.59
Q2 2025	188,864	$52,733	$277.77	$255.23 - $307.44
Q1 2025	225,868	$70,369	$287.24	$248.95 - $327.92
Q4 2024	304,727	$79,424	$286.05	$245.31 - $316.26
Q3 2024	601,662	$193,862	$313.17	$292.07 - $330.95
Q2 2024	578,296	$180,689	$279.32	$246.97 - $311.17
Q1 2024	418,567	$119,007	$276.08	$254.07 - $309.96
Q4 2023	976,584	$281,276	$255.10	$232.90 - $271.72
Q3 2023	722,250	$194,112	$231.86	$202.11 - $255.21
Q2 2023	364,113	$80,840	$213.65	$195.88 - $235.05
Q1 2023	355,756	$86,004	$224.03	$206.60 - $251.53
Q4 2022	373,240	$98,028	$242.73	$204.31 - $267.70
Q3 2021	169,238	$35,988	$200.25	$184.86 - $217.02
Q2 2021	38,038	$9,272	$212.50	$198.84 - $224.64
Q1 2021	441,038	$109,735	$204.69	$189.57 - $236.38
Q4 2020	503,138	$115,681	$196.32	$178.44 - $219.36
Q3 2020	621,167	$157,876	$209.54	$196.05 - $223.35
Q2 2020	833,572	$196,606	$191.68	$162.60 - $206.00
Q1 2020	619,872	$125,667	$182.24	$148.24 - $202.72
Q4 2019	410,547	$98,971	$182.69	$155.91 - $203.67
Q3 2019	372,247	$72,034	$158.01	$141.97 - $174.23
Q2 2019	78,947	$14,548	$146.19	$135.21 - $160.07
Q1 2019	213,247	$40,513	$154.67	$144.94 - $164.86
Q4 2018	413,055	$80,409	$156.83	$143.85 - $168.62
Q3 2018	452,755	$93,852	$157.37	$145.39 - $168.41
Q2 2018	735,055	$135,684	$140.24	$128.97 - $149.68
Q1 2018	575,907	$98,181	$144.43	$131.87 - $157.72
Q4 2017	929,409	$161,624	$138.21	$131.02 - $147.91
Q3 2017	816,109	$152,164	$137.50	$129.63 - $148.76
Q2 2017	927,009	$159,659	$125.35	$117.66 - $135.67
Q1 2017	989,109	$162,283	$127.19	$112.17 - $141.42
Q4 2016	916,709	$134,032	$114.37	$101.21 - $127.75
Q3 2016	940,409	$156,870	$127.72	$114.64 - $133.93
Q2 2016	1,085,109	$165,099	$116.70	$108.29 - $123.20
Q1 2016	1,092,959	$163,867	$110.79	$103.99 - $119.01
Q4 2015	1,291,559	$209,659	$116.50	$100.25 - $122.74
Q3 2015	1,290,159	$178,455	$116.24	$96.15 - $133.76
Q2 2015	972,959	$149,369	$117.59	$110.98 - $127.09
Q1 2015	747,959	$119,561	$115.04	$107.36 - $126.18
Q4 2014	584,621	$93,124	$113.30	$92.62 - $126.09
Q3 2014	253,500	$35,607	$94.52	$82.98 - $104.80
Q2 2014	720,400	$85,274	$83.37	$77.69 - $91.37
Q1 2014	953,900	$117,654	$86.89	$80.81 - $92.60
Q4 2013	1,367,300	$155,982	$81.11	$75.24 - $85.16
Q3 2013	2,071,500	$231,853	$76.98	$67.33 - $83.88
Q2 2013	445,348	$43,938	$73.34	$66.69 - $81.06
Q1 2013	553,148	$56,703	$62.49	$57.21 - $72.37