AMGEN INC

Ticker: AMGN CUSIP: 031162100 Class: COM

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 700,388 Value ($000) $229,244 Avg Close $315.95 Range $281.00 - $346.38

Q3 2025

Shares 76,425 Value ($000) $21,567 Avg Close $286.59 Range $267.86 - $306.59

Q2 2025

Shares 3,243 Value ($000) $905 Avg Close $277.77 Range $255.23 - $307.44

Q1 2025

Shares 359,516 Value ($000) $112,007 Avg Close $287.24 Range $248.95 - $327.92

Q4 2024

Shares 902,286 Value ($000) $235,172 Avg Close $286.05 Range $245.31 - $316.26

Q3 2024

Shares 358,741 Value ($000) $115,590 Avg Close $313.17 Range $292.07 - $330.95

Q2 2024

Shares 542,148 Value ($000) $169,394 Avg Close $279.32 Range $246.97 - $311.17

Q1 2024

Shares 112,383 Value ($000) $31,953 Avg Close $276.08 Range $254.07 - $309.96

Q4 2023

Shares 97,241 Value ($000) $28,007 Avg Close $255.10 Range $232.90 - $271.72

Q3 2023

Shares 715,988 Value ($000) $192,429 Avg Close $231.86 Range $202.11 - $255.21

Q2 2023

Shares 986,901 Value ($000) $219,112 Avg Close $213.65 Range $195.88 - $235.05

Q1 2023

Shares 945,475 Value ($000) $228,569 Avg Close $224.03 Range $206.60 - $251.53

Q4 2022

Shares 927,951 Value ($000) $243,717 Avg Close $242.73 Range $204.31 - $267.70

Q3 2022

Shares 930,235 Value ($000) $209,675 Avg Close $217.87 Range $201.50 - $227.98

Q2 2022

Shares 803,833 Value ($000) $195,573 Avg Close $218.58 Range $201.93 - $231.00

Q1 2022

Shares 1,045,215 Value ($000) $252,754 Avg Close $203.29 Range $190.45 - $218.06

Q4 2021

Shares 992,292 Value ($000) $223,236 Avg Close $185.15 Range $174.95 - $203.49

Q3 2021

Shares 1,064,945 Value ($000) $226,461 Avg Close $200.25 Range $184.86 - $217.02

Q2 2021

Shares 939,881 Value ($000) $229,096 Avg Close $212.50 Range $198.84 - $224.64

Q4 2020

Shares 6,100 Value ($000) $1,403 Avg Close $196.32 Range $178.44 - $219.36

Q2 2020

Shares 325,550 Value ($000) $76,784 Avg Close $191.68 Range $162.60 - $206.00

Q1 2020

Shares 142,881 Value ($000) $28,966 Avg Close $182.24 Range $148.24 - $202.72

Q4 2019

Shares 28,333 Value ($000) $6,830 Avg Close $182.69 Range $155.91 - $203.67

Q3 2019

Shares 93,816 Value ($000) $18,154 Avg Close $158.01 Range $141.97 - $174.23

Q2 2019

Shares 687,478 Value ($000) $126,688 Avg Close $146.19 Range $135.21 - $160.07

Q1 2019

Shares 656,802 Value ($000) $124,779 Avg Close $154.67 Range $144.94 - $164.86

Q4 2018

Shares 86,086 Value ($000) $16,758 Avg Close $156.83 Range $143.85 - $168.62

Q3 2018

Shares 280,670 Value ($000) $58,180 Avg Close $157.37 Range $145.39 - $168.41

Q2 2018

Shares 588,469 Value ($000) $108,625 Avg Close $140.24 Range $128.97 - $149.68

Q1 2018

Shares 204,644 Value ($000) $34,888 Avg Close $144.43 Range $131.87 - $157.72

Q4 2017

Shares 571,383 Value ($000) $99,364 Avg Close $138.21 Range $131.02 - $147.91

Q3 2017

Shares 491,445 Value ($000) $91,630 Avg Close $137.50 Range $129.63 - $148.76

Q2 2017

Shares 600,731 Value ($000) $103,464 Avg Close $125.35 Range $117.66 - $135.67

Q1 2017

Shares 372,653 Value ($000) $61,141 Avg Close $127.19 Range $112.17 - $141.42

Q4 2016

Shares 498,004 Value ($000) $72,813 Avg Close $114.37 Range $101.21 - $127.75

Q3 2016

Shares 54,473 Value ($000) $9,087 Avg Close $127.72 Range $114.64 - $133.93

Q2 2016

Shares 619,345 Value ($000) $94,233 Avg Close $116.70 Range $108.29 - $123.20

Q1 2016

Shares 647,558 Value ($000) $97,088 Avg Close $110.79 Range $103.99 - $119.01

Q4 2015

Shares 201,283 Value ($000) $32,674 Avg Close $116.50 Range $100.25 - $122.74

Q3 2015

Shares 813,282 Value ($000) $112,493 Avg Close $116.24 Range $96.15 - $133.76

Q2 2015

Shares 1,054,908 Value ($000) $161,949 Avg Close $117.59 Range $110.98 - $127.09

Q1 2015

Shares 546,151 Value ($000) $87,302 Avg Close $115.04 Range $107.36 - $126.18

Q3 2014

Shares 149,268 Value ($000) $20,966 Avg Close $94.52 Range $82.98 - $104.80

Q2 2014

Shares 1,108,532 Value ($000) $131,217 Avg Close $83.37 Range $77.69 - $91.37

Q4 2013

Shares 317,965 Value ($000) $36,299 Avg Close $81.11 Range $75.24 - $85.16

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	700,388	$229,244	$315.95	$281.00 - $346.38
Q3 2025	76,425	$21,567	$286.59	$267.86 - $306.59
Q2 2025	3,243	$905	$277.77	$255.23 - $307.44
Q1 2025	359,516	$112,007	$287.24	$248.95 - $327.92
Q4 2024	902,286	$235,172	$286.05	$245.31 - $316.26
Q3 2024	358,741	$115,590	$313.17	$292.07 - $330.95
Q2 2024	542,148	$169,394	$279.32	$246.97 - $311.17
Q1 2024	112,383	$31,953	$276.08	$254.07 - $309.96
Q4 2023	97,241	$28,007	$255.10	$232.90 - $271.72
Q3 2023	715,988	$192,429	$231.86	$202.11 - $255.21
Q2 2023	986,901	$219,112	$213.65	$195.88 - $235.05
Q1 2023	945,475	$228,569	$224.03	$206.60 - $251.53
Q4 2022	927,951	$243,717	$242.73	$204.31 - $267.70
Q3 2022	930,235	$209,675	$217.87	$201.50 - $227.98
Q2 2022	803,833	$195,573	$218.58	$201.93 - $231.00
Q1 2022	1,045,215	$252,754	$203.29	$190.45 - $218.06
Q4 2021	992,292	$223,236	$185.15	$174.95 - $203.49
Q3 2021	1,064,945	$226,461	$200.25	$184.86 - $217.02
Q2 2021	939,881	$229,096	$212.50	$198.84 - $224.64
Q4 2020	6,100	$1,403	$196.32	$178.44 - $219.36
Q2 2020	325,550	$76,784	$191.68	$162.60 - $206.00
Q1 2020	142,881	$28,966	$182.24	$148.24 - $202.72
Q4 2019	28,333	$6,830	$182.69	$155.91 - $203.67
Q3 2019	93,816	$18,154	$158.01	$141.97 - $174.23
Q2 2019	687,478	$126,688	$146.19	$135.21 - $160.07
Q1 2019	656,802	$124,779	$154.67	$144.94 - $164.86
Q4 2018	86,086	$16,758	$156.83	$143.85 - $168.62
Q3 2018	280,670	$58,180	$157.37	$145.39 - $168.41
Q2 2018	588,469	$108,625	$140.24	$128.97 - $149.68
Q1 2018	204,644	$34,888	$144.43	$131.87 - $157.72
Q4 2017	571,383	$99,364	$138.21	$131.02 - $147.91
Q3 2017	491,445	$91,630	$137.50	$129.63 - $148.76
Q2 2017	600,731	$103,464	$125.35	$117.66 - $135.67
Q1 2017	372,653	$61,141	$127.19	$112.17 - $141.42
Q4 2016	498,004	$72,813	$114.37	$101.21 - $127.75
Q3 2016	54,473	$9,087	$127.72	$114.64 - $133.93
Q2 2016	619,345	$94,233	$116.70	$108.29 - $123.20
Q1 2016	647,558	$97,088	$110.79	$103.99 - $119.01
Q4 2015	201,283	$32,674	$116.50	$100.25 - $122.74
Q3 2015	813,282	$112,493	$116.24	$96.15 - $133.76
Q2 2015	1,054,908	$161,949	$117.59	$110.98 - $127.09
Q1 2015	546,151	$87,302	$115.04	$107.36 - $126.18
Q3 2014	149,268	$20,966	$94.52	$82.98 - $104.80
Q2 2014	1,108,532	$131,217	$83.37	$77.69 - $91.37
Q4 2013	317,965	$36,299	$81.11	$75.24 - $85.16