AMGEN INC

Ticker: AMGN CUSIP: 031162100 Class: COM

TWO SIGMA ADVISERS, LP's Holding History (CIK: 0001478735)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 735,880 Value ($000) $240,861 Avg Close $315.95 Range $281.00 - $346.38

Q3 2025

Shares 61,200 Value ($000) $17,271 Avg Close $286.59 Range $267.86 - $306.59

Q2 2025

Shares 4,100 Value ($000) $1,145 Avg Close $277.77 Range $255.23 - $307.44

Q1 2025

Shares 1,001,400 Value ($000) $311,986 Avg Close $287.24 Range $248.95 - $327.92

Q4 2024

Shares 1,545,600 Value ($000) $402,845 Avg Close $286.05 Range $245.31 - $316.26

Q3 2024

Shares 784,900 Value ($000) $252,903 Avg Close $313.17 Range $292.07 - $330.95

Q2 2024

Shares 716,900 Value ($000) $223,995 Avg Close $279.32 Range $246.97 - $311.17

Q1 2024

Shares 349,700 Value ($000) $99,427 Avg Close $276.08 Range $254.07 - $309.96

Q4 2023

Shares 1,158,700 Value ($000) $333,729 Avg Close $255.10 Range $232.90 - $271.72

Q3 2023

Shares 1,456,100 Value ($000) $391,341 Avg Close $231.86 Range $202.11 - $255.21

Q2 2023

Shares 1,602,900 Value ($000) $355,876 Avg Close $213.65 Range $195.88 - $235.05

Q1 2023

Shares 1,672,800 Value ($000) $404,399 Avg Close $224.03 Range $206.60 - $251.53

Q4 2022

Shares 1,537,400 Value ($000) $403,783 Avg Close $242.73 Range $204.31 - $267.70

Q3 2022

Shares 1,683,500 Value ($000) $379,461 Avg Close $217.87 Range $201.50 - $227.98

Q2 2022

Shares 1,661,700 Value ($000) $404,292 Avg Close $218.58 Range $201.93 - $231.00

Q1 2022

Shares 1,730,500 Value ($000) $418,470 Avg Close $203.29 Range $190.45 - $218.06

Q4 2021

Shares 1,808,400 Value ($000) $406,836 Avg Close $185.15 Range $174.95 - $203.49

Q3 2021

Shares 1,852,400 Value ($000) $393,913 Avg Close $200.25 Range $184.86 - $217.02

Q2 2021

Shares 1,280,400 Value ($000) $312,098 Avg Close $212.50 Range $198.84 - $224.64

Q1 2021

Shares 41,500 Value ($000) $10,326 Avg Close $204.69 Range $189.57 - $236.38

Q4 2020

Shares 7,700 Value ($000) $1,770 Avg Close $196.32 Range $178.44 - $219.36

Q3 2020

Shares 5,015 Value ($000) $1,275 Avg Close $209.54 Range $196.05 - $223.35

Q2 2020

Shares 247,651 Value ($000) $58,411 Avg Close $191.68 Range $162.60 - $206.00

Q1 2020

Shares 228,151 Value ($000) $46,253 Avg Close $182.24 Range $148.24 - $202.72

Q4 2019

Shares 536,196 Value ($000) $129,261 Avg Close $182.69 Range $155.91 - $203.67

Q3 2019

Shares 1,013,396 Value ($000) $196,102 Avg Close $158.01 Range $141.97 - $174.23

Q2 2019

Shares 2,664,596 Value ($000) $491,032 Avg Close $146.19 Range $135.21 - $160.07

Q1 2019

Shares 2,249,296 Value ($000) $427,321 Avg Close $154.67 Range $144.94 - $164.86

Q4 2018

Shares 2,069,296 Value ($000) $402,830 Avg Close $156.83 Range $143.85 - $168.62

Q3 2018

Shares 1,753,696 Value ($000) $363,524 Avg Close $157.37 Range $145.39 - $168.41

Q2 2018

Shares 1,571,596 Value ($000) $290,101 Avg Close $140.24 Range $128.97 - $149.68

Q1 2018

Shares 791,496 Value ($000) $134,934 Avg Close $144.43 Range $131.87 - $157.72

Q4 2017

Shares 2,299,196 Value ($000) $399,830 Avg Close $138.21 Range $131.02 - $147.91

Q3 2017

Shares 2,168,696 Value ($000) $404,353 Avg Close $137.50 Range $129.63 - $148.76

Q2 2017

Shares 2,153,796 Value ($000) $370,948 Avg Close $125.35 Range $117.66 - $135.67

Q1 2017

Shares 487,699 Value ($000) $80,017 Avg Close $127.19 Range $112.17 - $141.42

Q4 2016

Shares 1,198,411 Value ($000) $175,220 Avg Close $114.37 Range $101.21 - $127.75

Q3 2016

Shares 211,741 Value ($000) $35,321 Avg Close $127.72 Range $114.64 - $133.93

Q2 2016

Shares 384,704 Value ($000) $58,533 Avg Close $116.70 Range $108.29 - $123.20

Q1 2016

Shares 415,904 Value ($000) $62,356 Avg Close $110.79 Range $103.99 - $119.01

Q4 2015

Shares 159,201 Value ($000) $25,843 Avg Close $116.50 Range $100.25 - $122.74

Q3 2015

Shares 935,170 Value ($000) $129,744 Avg Close $116.24 Range $96.15 - $133.76

Q2 2015

Shares 874,047 Value ($000) $134,184 Avg Close $117.59 Range $110.98 - $127.09

Q1 2015

Shares 707,589 Value ($000) $113,108 Avg Close $115.04 Range $107.36 - $126.18

Q4 2014

Shares 25,589 Value ($000) $4,076 Avg Close $113.30 Range $92.62 - $126.09

Q3 2014

Shares 28,865 Value ($000) $4,054 Avg Close $94.52 Range $82.98 - $104.80

Q2 2014

Shares 694,065 Value ($000) $82,156 Avg Close $83.37 Range $77.69 - $91.37

Q4 2013

Shares 40,065 Value ($000) $4,574 Avg Close $81.11 Range $75.24 - $85.16

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	735,880	$240,861	$315.95	$281.00 - $346.38
Q3 2025	61,200	$17,271	$286.59	$267.86 - $306.59
Q2 2025	4,100	$1,145	$277.77	$255.23 - $307.44
Q1 2025	1,001,400	$311,986	$287.24	$248.95 - $327.92
Q4 2024	1,545,600	$402,845	$286.05	$245.31 - $316.26
Q3 2024	784,900	$252,903	$313.17	$292.07 - $330.95
Q2 2024	716,900	$223,995	$279.32	$246.97 - $311.17
Q1 2024	349,700	$99,427	$276.08	$254.07 - $309.96
Q4 2023	1,158,700	$333,729	$255.10	$232.90 - $271.72
Q3 2023	1,456,100	$391,341	$231.86	$202.11 - $255.21
Q2 2023	1,602,900	$355,876	$213.65	$195.88 - $235.05
Q1 2023	1,672,800	$404,399	$224.03	$206.60 - $251.53
Q4 2022	1,537,400	$403,783	$242.73	$204.31 - $267.70
Q3 2022	1,683,500	$379,461	$217.87	$201.50 - $227.98
Q2 2022	1,661,700	$404,292	$218.58	$201.93 - $231.00
Q1 2022	1,730,500	$418,470	$203.29	$190.45 - $218.06
Q4 2021	1,808,400	$406,836	$185.15	$174.95 - $203.49
Q3 2021	1,852,400	$393,913	$200.25	$184.86 - $217.02
Q2 2021	1,280,400	$312,098	$212.50	$198.84 - $224.64
Q1 2021	41,500	$10,326	$204.69	$189.57 - $236.38
Q4 2020	7,700	$1,770	$196.32	$178.44 - $219.36
Q3 2020	5,015	$1,275	$209.54	$196.05 - $223.35
Q2 2020	247,651	$58,411	$191.68	$162.60 - $206.00
Q1 2020	228,151	$46,253	$182.24	$148.24 - $202.72
Q4 2019	536,196	$129,261	$182.69	$155.91 - $203.67
Q3 2019	1,013,396	$196,102	$158.01	$141.97 - $174.23
Q2 2019	2,664,596	$491,032	$146.19	$135.21 - $160.07
Q1 2019	2,249,296	$427,321	$154.67	$144.94 - $164.86
Q4 2018	2,069,296	$402,830	$156.83	$143.85 - $168.62
Q3 2018	1,753,696	$363,524	$157.37	$145.39 - $168.41
Q2 2018	1,571,596	$290,101	$140.24	$128.97 - $149.68
Q1 2018	791,496	$134,934	$144.43	$131.87 - $157.72
Q4 2017	2,299,196	$399,830	$138.21	$131.02 - $147.91
Q3 2017	2,168,696	$404,353	$137.50	$129.63 - $148.76
Q2 2017	2,153,796	$370,948	$125.35	$117.66 - $135.67
Q1 2017	487,699	$80,017	$127.19	$112.17 - $141.42
Q4 2016	1,198,411	$175,220	$114.37	$101.21 - $127.75
Q3 2016	211,741	$35,321	$127.72	$114.64 - $133.93
Q2 2016	384,704	$58,533	$116.70	$108.29 - $123.20
Q1 2016	415,904	$62,356	$110.79	$103.99 - $119.01
Q4 2015	159,201	$25,843	$116.50	$100.25 - $122.74
Q3 2015	935,170	$129,744	$116.24	$96.15 - $133.76
Q2 2015	874,047	$134,184	$117.59	$110.98 - $127.09
Q1 2015	707,589	$113,108	$115.04	$107.36 - $126.18
Q4 2014	25,589	$4,076	$113.30	$92.62 - $126.09
Q3 2014	28,865	$4,054	$94.52	$82.98 - $104.80
Q2 2014	694,065	$82,156	$83.37	$77.69 - $91.37
Q4 2013	40,065	$4,574	$81.11	$75.24 - $85.16