AMPHASTAR PHARMACEUTICALS IN

Ticker: AMPH CUSIP: 03209R103 Class: Common Stock

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 98,678 Value ($000) $2,643 Avg Close $25.76 Range $22.94 - $29.00

Q3 2025

Shares 98,678 Value ($000) $2,630 Avg Close $25.82 Range $20.39 - $31.26

Q2 2025

Shares 80,130 Value ($000) $1,840 Avg Close $24.82 Range $22.64 - $29.27

Q1 2025

Shares 75,328 Value ($000) $2,184 Avg Close $31.94 Range $25.89 - $39.01

Q4 2024

Shares 98,184 Value ($000) $3,646 Avg Close $45.73 Range $36.48 - $53.96

Q3 2024

Shares 98,798 Value ($000) $4,795 Avg Close $43.89 Range $36.56 - $50.62

Q2 2024

Shares 96,430 Value ($000) $3,857 Avg Close $41.44 Range $38.43 - $46.62

Q1 2024

Shares 96,804 Value ($000) $4,251 Avg Close $51.65 Range $42.16 - $65.92

Q4 2023

Shares 41,775 Value ($000) $2,584 Avg Close $52.53 Range $43.79 - $63.67

Q3 2023

Shares 95,484 Value ($000) $4,391 Avg Close $54.55 Range $44.86 - $67.66

Q2 2023

Shares 30,010 Value ($000) $1,725 Avg Close $44.33 Range $35.62 - $58.70

Q2 2022

Shares 21,200 Value ($000) $738 Avg Close $35.69 Range $28.64 - $44.46

Q1 2021

Shares 88,375 Value ($000) $1,619 Avg Close $18.59 Range $17.11 - $20.93

Q3 2020

Shares 189,010 Value ($000) $3,544 Avg Close $20.14 Range $17.83 - $22.69

Q2 2020

Shares 53,410 Value ($000) $1,200 Avg Close $18.31 Range $14.00 - $22.50

Q2 2019

Shares 31,917 Value ($000) $674 Avg Close $20.90 Range $18.60 - $23.06

Q4 2018

Shares 26,000 Value ($000) $517 Avg Close $19.71 Range $17.71 - $22.74

Q1 2018

Shares 44,676 Value ($000) $838 Avg Close $18.80 Range $16.76 - $20.45

Q4 2016

Shares 78,456 Value ($000) $1,445 Avg Close $19.45 Range $16.87 - $21.75

Q3 2016

Shares 129,086 Value ($000) $2,449 Avg Close $18.15 Range $15.62 - $21.53

Q2 2016

Shares 134,745 Value ($000) $2,172 Avg Close $14.11 Range $11.41 - $16.78

Q1 2016

Shares 116,133 Value ($000) $1,394 Avg Close $11.79 Range $10.50 - $14.18

Q4 2015

Shares 75,750 Value ($000) $1,078 Avg Close $13.21 Range $10.57 - $15.84

Q3 2015

Shares 40,905 Value ($000) $478 Avg Close $15.00 Range $10.61 - $18.30

Q2 2015

Shares 217,641 Value ($000) $3,826 Avg Close $15.59 Range $13.55 - $18.25

Q1 2015

Shares 87,057 Value ($000) $1,302 Avg Close $13.37 Range $11.12 - $15.79

Q4 2014

Shares 39,659 Value ($000) $460 Avg Close $10.89 Range $9.76 - $12.46

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	98,678	$2,643	$25.76	$22.94 - $29.00
Q3 2025	98,678	$2,630	$25.82	$20.39 - $31.26
Q2 2025	80,130	$1,840	$24.82	$22.64 - $29.27
Q1 2025	75,328	$2,184	$31.94	$25.89 - $39.01
Q4 2024	98,184	$3,646	$45.73	$36.48 - $53.96
Q3 2024	98,798	$4,795	$43.89	$36.56 - $50.62
Q2 2024	96,430	$3,857	$41.44	$38.43 - $46.62
Q1 2024	96,804	$4,251	$51.65	$42.16 - $65.92
Q4 2023	41,775	$2,584	$52.53	$43.79 - $63.67
Q3 2023	95,484	$4,391	$54.55	$44.86 - $67.66
Q2 2023	30,010	$1,725	$44.33	$35.62 - $58.70
Q2 2022	21,200	$738	$35.69	$28.64 - $44.46
Q1 2021	88,375	$1,619	$18.59	$17.11 - $20.93
Q3 2020	189,010	$3,544	$20.14	$17.83 - $22.69
Q2 2020	53,410	$1,200	$18.31	$14.00 - $22.50
Q2 2019	31,917	$674	$20.90	$18.60 - $23.06
Q4 2018	26,000	$517	$19.71	$17.71 - $22.74
Q1 2018	44,676	$838	$18.80	$16.76 - $20.45
Q4 2016	78,456	$1,445	$19.45	$16.87 - $21.75
Q3 2016	129,086	$2,449	$18.15	$15.62 - $21.53
Q2 2016	134,745	$2,172	$14.11	$11.41 - $16.78
Q1 2016	116,133	$1,394	$11.79	$10.50 - $14.18
Q4 2015	75,750	$1,078	$13.21	$10.57 - $15.84
Q3 2015	40,905	$478	$15.00	$10.61 - $18.30
Q2 2015	217,641	$3,826	$15.59	$13.55 - $18.25
Q1 2015	87,057	$1,302	$13.37	$11.12 - $15.79
Q4 2014	39,659	$460	$10.89	$9.76 - $12.46