AMPHASTAR PHARMACEUTICALS IN

Ticker: AMPH CUSIP: 03209R103 Class: Common Stock

TWO SIGMA ADVISERS, LP's Holding History (CIK: 0001478735)

Note: Option positions (PUT/CALL) are excluded.

Q3 2025

Shares 22,800 Value ($000) $608 Avg Close $25.82 Range $20.39 - $31.26

Q2 2025

Shares 95,200 Value ($000) $2,186 Avg Close $24.82 Range $22.64 - $29.27

Q1 2025

Shares 84,700 Value ($000) $2,455 Avg Close $31.94 Range $25.89 - $39.01

Q4 2024

Shares 85,900 Value ($000) $3,189 Avg Close $45.73 Range $36.48 - $53.96

Q3 2024

Shares 98,300 Value ($000) $4,770 Avg Close $43.89 Range $36.56 - $50.62

Q2 2024

Shares 106,100 Value ($000) $4,244 Avg Close $41.44 Range $38.43 - $46.62

Q1 2024

Shares 125,900 Value ($000) $5,528 Avg Close $51.65 Range $42.16 - $65.92

Q4 2023

Shares 127,400 Value ($000) $7,880 Avg Close $52.53 Range $43.79 - $63.67

Q3 2023

Shares 85,400 Value ($000) $3,928 Avg Close $54.55 Range $44.86 - $67.66

Q2 2023

Shares 72,600 Value ($000) $4,172 Avg Close $44.33 Range $35.62 - $58.70

Q1 2023

Shares 59,100 Value ($000) $2,216 Avg Close $32.78 Range $27.58 - $38.22

Q4 2022

Shares 80,400 Value ($000) $2,253 Avg Close $29.04 Range $26.76 - $31.64

Q3 2022

Shares 90,600 Value ($000) $2,546 Avg Close $32.65 Range $27.10 - $39.07

Q2 2022

Shares 111,400 Value ($000) $3,876 Avg Close $35.69 Range $28.64 - $44.46

Q1 2022

Shares 23,700 Value ($000) $851 Avg Close $28.36 Range $22.07 - $37.16

Q4 2021

Shares 17,500 Value ($000) $408 Avg Close $20.45 Range $18.12 - $23.85

Q3 2021

Shares 16,600 Value ($000) $316 Avg Close $19.59 Range $17.56 - $21.63

Q2 2021

Shares 17,400 Value ($000) $351 Avg Close $18.84 Range $16.91 - $20.94

Q1 2021

Shares 38,600 Value ($000) $707 Avg Close $18.59 Range $17.11 - $20.93

Q4 2020

Shares 41,500 Value ($000) $835 Avg Close $19.46 Range $17.51 - $21.38

Q3 2020

Shares 157,100 Value ($000) $2,946 Avg Close $20.14 Range $17.83 - $22.69

Q3 2019

Shares 22,300 Value ($000) $442 Avg Close $20.83 Range $18.66 - $22.85

Q2 2019

Shares 34,900 Value ($000) $737 Avg Close $20.90 Range $18.60 - $23.06

Q1 2019

Shares 24,700 Value ($000) $505 Avg Close $22.40 Range $19.32 - $25.43

Q4 2018

Shares 13,800 Value ($000) $275 Avg Close $19.71 Range $17.71 - $22.74

Q1 2018

Shares 12,200 Value ($000) $229 Avg Close $18.80 Range $16.76 - $20.45

Q3 2017

Shares 10,300 Value ($000) $184 Avg Close $16.45 Range $14.53 - $18.67

Q2 2017

Shares 13,300 Value ($000) $238 Avg Close $15.86 Range $13.15 - $17.95

Q1 2017

Shares 60,700 Value ($000) $880 Avg Close $15.72 Range $12.05 - $19.64

Q4 2016

Shares 88,200 Value ($000) $1,625 Avg Close $19.45 Range $16.87 - $21.75

Q3 2016

Shares 103,600 Value ($000) $1,965 Avg Close $18.15 Range $15.62 - $21.53

Q2 2016

Shares 116,700 Value ($000) $1,881 Avg Close $14.11 Range $11.41 - $16.78

Q1 2016

Shares 122,000 Value ($000) $1,464 Avg Close $11.79 Range $10.50 - $14.18

Q4 2015

Shares 118,438 Value ($000) $1,685 Avg Close $13.21 Range $10.57 - $15.84

Q3 2015

Shares 126,302 Value ($000) $1,495 Avg Close $15.00 Range $10.61 - $18.30

Q2 2015

Shares 174,701 Value ($000) $3,071 Avg Close $15.59 Range $13.55 - $18.25

Q1 2015

Shares 25,100 Value ($000) $375 Avg Close $13.37 Range $11.12 - $15.79

Period	Shares	Value ($000)	Average Close	Price Range
Q3 2025	22,800	$608	$25.82	$20.39 - $31.26
Q2 2025	95,200	$2,186	$24.82	$22.64 - $29.27
Q1 2025	84,700	$2,455	$31.94	$25.89 - $39.01
Q4 2024	85,900	$3,189	$45.73	$36.48 - $53.96
Q3 2024	98,300	$4,770	$43.89	$36.56 - $50.62
Q2 2024	106,100	$4,244	$41.44	$38.43 - $46.62
Q1 2024	125,900	$5,528	$51.65	$42.16 - $65.92
Q4 2023	127,400	$7,880	$52.53	$43.79 - $63.67
Q3 2023	85,400	$3,928	$54.55	$44.86 - $67.66
Q2 2023	72,600	$4,172	$44.33	$35.62 - $58.70
Q1 2023	59,100	$2,216	$32.78	$27.58 - $38.22
Q4 2022	80,400	$2,253	$29.04	$26.76 - $31.64
Q3 2022	90,600	$2,546	$32.65	$27.10 - $39.07
Q2 2022	111,400	$3,876	$35.69	$28.64 - $44.46
Q1 2022	23,700	$851	$28.36	$22.07 - $37.16
Q4 2021	17,500	$408	$20.45	$18.12 - $23.85
Q3 2021	16,600	$316	$19.59	$17.56 - $21.63
Q2 2021	17,400	$351	$18.84	$16.91 - $20.94
Q1 2021	38,600	$707	$18.59	$17.11 - $20.93
Q4 2020	41,500	$835	$19.46	$17.51 - $21.38
Q3 2020	157,100	$2,946	$20.14	$17.83 - $22.69
Q3 2019	22,300	$442	$20.83	$18.66 - $22.85
Q2 2019	34,900	$737	$20.90	$18.60 - $23.06
Q1 2019	24,700	$505	$22.40	$19.32 - $25.43
Q4 2018	13,800	$275	$19.71	$17.71 - $22.74
Q1 2018	12,200	$229	$18.80	$16.76 - $20.45
Q3 2017	10,300	$184	$16.45	$14.53 - $18.67
Q2 2017	13,300	$238	$15.86	$13.15 - $17.95
Q1 2017	60,700	$880	$15.72	$12.05 - $19.64
Q4 2016	88,200	$1,625	$19.45	$16.87 - $21.75
Q3 2016	103,600	$1,965	$18.15	$15.62 - $21.53
Q2 2016	116,700	$1,881	$14.11	$11.41 - $16.78
Q1 2016	122,000	$1,464	$11.79	$10.50 - $14.18
Q4 2015	118,438	$1,685	$13.21	$10.57 - $15.84
Q3 2015	126,302	$1,495	$15.00	$10.61 - $18.30
Q2 2015	174,701	$3,071	$15.59	$13.55 - $18.25
Q1 2015	25,100	$375	$13.37	$11.12 - $15.79