AMPIO PHARMACEUTICALS INC

CUSIP: 03209T109 Class: COM

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q3 2022
Shares 198,348 Value ($000) $12 Avg Close — Range —
Q2 2022
Shares 64,748 Value ($000) $11 Avg Close — Range —