ANIKA THERAPEUTICS INC

Ticker: ANIK CUSIP: 035255108 Class: COM

FIRST MANHATTAN CO. LLC.'s Holding History (CIK: 0000728083)

Note: Option positions (PUT/CALL) are excluded.

Q4 2018

Shares 409,852 Value ($000) $13,775 Avg Close $36.09 Range $29.58 - $43.45

Q3 2018

Shares 409,852 Value ($000) $17,287 Avg Close $39.51 Range $31.91 - $44.95

Q2 2018

Shares 492,602 Value ($000) $15,763 Avg Close $41.18 Range $28.54 - $49.75

Q1 2018

Shares 38,700 Value ($000) $1,924 Avg Close $56.50 Range $45.74 - $69.81

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2018	409,852	$13,775	$36.09	$29.58 - $43.45
Q3 2018	409,852	$17,287	$39.51	$31.91 - $44.95
Q2 2018	492,602	$15,763	$41.18	$28.54 - $49.75
Q1 2018	38,700	$1,924	$56.50	$45.74 - $69.81